At the crossroad of researches in relation with microbial virulence, drug resistance mechanisms, drug target characterization and medicinal/supramolecular chemistry

Our research covers a wide spectrum of activities incorporating the elucidation of viral and bacterial virulence and of antibacterial drug resistance mechanisms, the conception of molecules and polymers designed for potential therapeutic applications, the discovery of new antimicrobial activities, the supramolecular chemistry and the structural characterization of biomacromolecules

About us

logo unité microbiologie The Microbiology, Bioorganic and Macromolecular Chemistry (MBMC) unit of the ULB Faculty of Pharmacy is a multidisciplinary team, composed of members from different backgrounds and different areas of expertise.

The research group directed by Prof. Meyer is focused on supramolecular chemistry mainly based on halogen bonding and the preparation of polymers targeting functional materials and biomaterials.

The Dufrasne's research group is especially involved in solving problems related to the finding of new hits as receptor agonists/antagonists or enzyme inhibitors in collaboration with other teams working on molecular docking and protein crystallization at the University. Further developments can be made in-house such as lead generation, toxicological testing and drug preformulation to achieve animal testing.

The Berger Lab has broad interest in organic and theoretical chemistry, biomedical sciences and oncology. We use complementary and multi-disciplinary skills toward the advancement of fundamental projects as well as in applications such as drug discovery and novel anticancer medicines. Our research takes its roots in chemistry, more precisely in synthetic and bioorganic chemistry: chemistry is the central field developed into several branches that span from nanomedicine to medicinal and computational chemistry. Although having an history of anticancer metal complexes, novel immune-oncology therapies targeted to the modulation of the immune environment of cold tumors is now a major focus.

The research group in Microbiology directed by Prof. Fontaine is mainly focused to fight two diseases: the cervical cancer due to the high-risk human papillomaviruses (HPV) and the tuberculosis mainly due to M. tuberculosis. In virology, we are currently studying the transcriptional HPV-16 promoter regulation and the integration mechanism of the viral genome but we are also working with the Universidad Mayor San Simon at Cochabamba in Bolivia to improve the cervical cancer screening and treatment. In mycobacteriology, we are studying the M. tuberculosis mechanisms allowing the pathogen to escape drug bactericidal activities and to develop virulence. This lead us to characterize new targets and discover new antituberculous drug candidates. Our laboratory can perform microbiological controls of pharmaceutic and cosmetic products, water, surface, antimicrobial and anti-biofilm activity testing (all possible under GLP, ISO 17025) with ATCC microorganisms (bacteria and fungi), either for pharmaceutical or cosmetic purposes.

Research of Wintjens'group is mainly concerned with, but not limited to, the characterization of interactions at atomic level between a protein target and drug-like small molecules with the primary aim of setting up a rational basis for the development of new drugs.

Team

Senior scientists

Prof. Franck MEYER
+32 (0) 2 650 51 96
franck.meyer@ulb.be

Prof. Gilles BERGER
+32 (0) 2 650 51 80
gilles.berger@ulb.be

Prof. Véronique FONTAINE
+32 (0) 2 650 52 96
veronique.fontaine@ulb.be

Prof. René WINTJENS
+32 (0) 2 650 51 76
rene.wintjens@ulb.be

Prof. François DUFRASNE
+32 (0) 2 650 52 35
francois.dufrasne@ulb.be

 

 

Postdoctoral fellows and scientific collaborators

Prof. Michel GELBCKE
+32 (0) 2 650 52 35
michel.gelbcke@ulb.be

Dr. Shiv KUMAR
+32 (0) 2 650 52 89
shiv.kumar@ulb.be

 

PhD students

Sarah REIBEL
+32 (0) 2 650 52 48
sarah.reibel@ulb.be

Pierre FRANGVILLE
+32 (0) 2 650 52 89
pierre.frangville@ulb.be

Faustine RAVON
+32 (0) 2 650 53 18
faustine.ravon@ulb.ac.be
 

Ibrahima Sory SOW
+32 (0) 2 650 52 89
ibrahima.sory.sow@ulb.be

Camille GROSSE
+32 (0) 2 526 72 80
camille.grosse@ulb.be

Danlei SUN
+32 (0) 2 650 51 74
danlei.sun@ulb.be

Isaline LAMBERT
+32 (0) 2 650 53 18
isalinelambert2806@gmail.com

Evodie NUMBI
+32 (0) 2 650 52 96
evodienumbi@gmail.com

Zhiyu ZHOU
+32 (0) 2 650 51 74
zhiyu.zhou@ulb.be

Eva CHOQUENET
+32 (0) 2 650 52 48
eva.choquent@ulb.be

 

Administrative, technical, management and/or specialized members

Naïma EL MANSOURI
+32 (0) 2 650 53 13
naima.el.manssouri@ulb.be

Dr. Véronique MEGALIZZI
+32 (0) 2 650 51 74
veronique.megalizzi@ulb.be

Jérôme VANHEUVERZWIJN
+32 (0) 2 650 59 31
jerome.vanheuverzwijn@ulb.be

Master students


Alumni

ALARD Ibaa Chikh (2013-2018)
PhD

ALBERT Ekaterina (2015-2019)
PhD

ALLENDE Gustavo (2015-2020)
PhD

AL NAKIB Rana (2018-2021)
PhD

BOUSSARD Paule (2008-2019)
Professor

FOUOTSA Hugues (2019)
Postdoc - University of Yaoundé I (Cameroon)

LIANG Jingwen (2016-2018)
PhD

MARLOYE Michaël (2015-2021)
PhD

RALET Janine (1990-2018)
Technician

RENS Céline (2011-2018)
PhD

SURRIABRE Pedro (2014-2019)
PhD

TANINA Abdalkarim (2015-2021)
PhD and Postdoc

YANG Dong (2014-2020)
PhD

ZENG Shen (2014-2019)
PhD


 
Skills

• Organic synthesis

• Supramolecular chemistry

• Polymer chemistry

• Functional materials

• NMR analysis

• Structure-activity relationships

• Mycobacteriology

• Antimicrobial and anti-biofilm activities

• Transcriptional regulation

• X-ray crystallography

• Structural biology

• Structure-based drug design

Publications
2022
  • R. Al Nakib, A. Toncheva, V. Fontaine, J. Vanheuverzwijn, J. M. Raquez and F. Meyer, Thermoplastic polyurethanes for biomedical application: a synthetic, mechanical, antibacterial, and cytotoxic study, J. Appl. Polym. Sci., 2022, 139, e51666.
  • A. G. N. Avila, B. Deschênes-Simard, J. E. Arnold, M. Morency, D. Chartrand, T. Maris, G. Berger, G. M. Day, S. Hanessian and J. D. Wuest, Surprising chemistry of 6-azidotetrazolo[5,1- a]phthalazine: what a purported natural product reveals about the polymorphism of explosives, J. Org. Chem., 2022, 87, 6680-6694. pubmed
  • S. Bensemmane, K. Loayza Villarroel, K. Montaño, E. Louati, C. Ascarrunz, P. Rodriguez, V.  Fontaine and S. Laokri, Assessing barriers encountered by women in cervical cancer screening and follow-up care in urban Bolivia, Cochabamba. Healthcare, 2022, 10, 1604.
  • G. Berger, E. H. Knelson, J. L. Jimenez-Macias, M. O. Nowicki, S. Han, E. Panagioti, P. H. Lizotte, K. Adu-Berchie, A. Stafford, N. Dimitrakakis, L. Zhou, E. A. Chiocca, D. J. Mooney, D. A. Barbie and S. E. Lawler,  STING activation promotes robust immune response and NK cell-mediated tumor regression in glioblastoma models. Proc. Natl. Acad. Sci. USA, 2022, 119, e2111003119. pubmed
  • T. Demaret, R. Wintjens, G. Sana, J. Docquir, F. Bertin, C. Ide, O. Monestier, D. Karadurmus, V. Benoit and I. Maystadt, Case report: inactivating PTH/PTHrP signaling disorder type 1 presenting with PTH resistance. Front. Endocrinol. (Lausanne), 2022, 13, 928284. pubmed
  • F. Dufrasne, Baloxavir marboxil : an original new drug against influenza. Pharmaceuticals, 2022, 15, 28. pubmed
  • M. Flipo, R. Frita, M. Bourotte, M. S. Martínez-Martínez, M. Boesche, G. W. Boyle, G. Derimanov, G. Drewes, P. Gamallo, S. Ghidelli-Disse, S. Gresham, E. Jiménez, J. de Mercado, E. Pérez-Herrán, E. Porras-De Francisco, J. Rullas, P. Casado, F. Leroux, C. Piveteau, M. Kiass, V. Mathys, K. Soetaert, V. Megalizzi, A. Tanina, R. Wintjens, R. Antoine, P. Brodin, V. Delorme, M. Moune, K. Djaout, S. Slupek, C. Kemmer, M. Gitzinger, L. Ballell, A. Mendoza-Losana, S. Lociuro, B. Deprez, D. Barros-Aguirre, M. J. Remuiñán, N. Willand and A. R. Baulard, The small-molecule SMARt751 reverses Mycobacterium tuberculosis resistance to ethionamide in acute and chronic mouse models of tuberculosis. Sci. Transl. Med., 2022, 14, eaaz6280. pubmed
  • S. Hocine, G. Berger, K. N. Houk and S. Hanessian, Catalytic properties of 4, 5-bridged proline methano-and ethanologues in the Hajos–Parrish intramolecular aldol reaction. Org. Chem. Front. , 2022, 9, 649-659.
  • J. L. Jimenez-Macias, Y. C. Lee, T. Finkelberg, G. Berger, M. Nowicki, C. F. Cho, B. Fedeles, A. Loas, B. Penetelute and S. E. Lawler, Pt (IV)-M13, a blood-brain-barrier penetrant macrocyclic peptide-platinum (IV) conjugate, leads to enhanced drug uptake and efficacy in murine glioblastoma models. Cancer Res., 2022, 82, 5329.
  • J. L. Jimenez-Macias, Y. C. Lee, T. Finkelberg, M. Zdioruk, G. Berger, E. Miller, C. E. Farquhar, M. O. Nowicki, C. F. Cho, B. Fedeles, A. Loas, B. L. Pentelute and S. E. Lawler, A macrocyclic peptide delivers platinum to the brain and shows pre-clinical efficacy in glioblastoma, accepted manuscript.
  • M. Marloye, H. Inam, C. J. Moore, T. R. Mertens, A. Ingels, M. Koch, M. O. Nowicki, V. Mathieu, J. R. Pritchard, S. G. Awuah, S. E. Lawler, F. Meyer, F. Dufrasne and G. Berger, Self-assembled ruthenium and osmium nanosystems display a potent anticancer profile by interfering with metabolic activity. Inorg. Chem. Front., 2022, 9, 2594-2607.
  • R. T. Mertens, C. E. Greif, J. T. Coogle, G. Berger, S. Parkin, M. D. Watson and S. G. Awuah, Stable Au(I) catalysts for oxidant-free C-H functionalization with iodoarenes. J. Catal., 2022, 408, 109-114. pubmed
  • F. Ravon, E. Menchi, C. Lambot, S. Al Kattar, S. Chraibi, M. Remmelink, V. Fontaine and N. Wauthoz, In vitro and in vivo local tolerability of a synergistic anti-tuberculosis drug combination intended for pulmonary delivery. J. Appl. Toxicol. in press. pubmed
  • L. Schawe, B. Raude, J. C. Carstens, I. Hinterseher, R. D. Hein, S. Omran, G. Berger, N. A. Hering, M. Buerger, A. Greiner and J. P. Frese, Effect of Revascularization on Intramuscular Vascular Endothelial Growth Factor Levels in Peripheral Arterial Disease. Biomedicines, 2022, 10, 471. pubmed
2021
  • G. Battisti, R. Wintjens, A. Decottignies, A. Merhi, C. Fervaille, E. Sokal, D. Karadurmus, V. Benoit, A. Claessens, J. P. Martinet, B. Martiat, P. Kinzinger and I. Maystadt, Child to adulthood clinical description of MDPL syndrome due to a novel variant in POLD1, 2021, Eur. J. Med. Genet., 64, 104333. pubmed
  • G. Berger, A. Wach, S. Jacinto and J. Szlachetko, Reduction mechanisms of anticancer osmium(VI) complexes revealed by atomic telemetry and theoretical calculations. Inorg. Chem., 2021, 60, 6663-6671. pubmed
  • H. Fouotsa, P. Mkounga, A. M. Lannang, J. Vanheuverzwijn, Z. Zhou, K. Leblanc, S. Rharrabti, A. E. Nkengfack, J. F. Gallard, V. Fontaine, F. Meyer, E. Poupon, P. Le Pogam and M. A. Beniddir, Pyrrovobasine, hybrid alkylated pyrraline monoterpene indole alkaloid pseudodimer discovered using a combination of mass spectral and NMR-based machine learning annotations. Org. Biomol. Chem., 2021, 20, 98-105. pubmed
  • H. Fouotsa, P. Le Pogam, P. Mkounga, A. M. Lannang, G. Bernadat, J. Vanheuverzwijn, Z. Zhou, K. Leblanc, S. Rharrabti, A. E. Nkengfack, J. F. Gallard, V. Fontaine, F. Meyer, E. Poupon and M. A. Beniddir, Voatriafricanines A and B, trimeric vobasine-aspidosperma-aspidosperma alkaloids from Voacanga africana. J. Nat. Prod., 2021, 84, 2755-2761. pubmed
  • H. Fouotsa, J. P. Dzoyem, A. M. Lannang, H. G. Stammler, C. D. Mbazoa, M. Luhmer, A. E. Nkengfack, E. Allémann, F. Delie, F. Meyer and N. Sewald, Antiproliferative activity of a new xanthone derivative from leaves of Garcinia nobilis Engl. Nat. Prod. Res. , 2021, 35, 5604-5611. pubmed
  • P. Frangville, S. Kumar, M. Gelbcke, K. Van Hecke and F. Meyer, Stimuli responsive materials supported by orthogonal hydrogen and halogen bonding or I···alkene interaction. Molecules, 2021, 26, 7586. pubmed
  • T. Kouamé, T. Okpekon, N. F. Bony, S. Ferron, D. Bonnaffé, J. Vanheuverzwijn, Z. Zhou, V. Fontaine, A. D. N’Tamon, J. F. Gallard, K. Leblanc, J. C. Jullian, C. Miel, P. Champy, M. A. Beniddir and P. Le Pogam, Anticipate, target and characterize: MS²-anticipated C glycosylflavones from Erythrococca anomala. Planta Medica International Open, 2021, 8, e131-e142.
  • J. J. Macias, Y. C. Lee, T. Finkelberg, M. Zdioruk, G. Berger, M. Nowicki, C. F. Cho, B. Fedeles, A. Loas, B. Pentelute and S. E. Lawler, Assessment of brain penetrance, biodistribution, and efficacy of platinum(IV)-conjugated fluorinated macrocyclic cell-penetrating peptides in a murine glioblastoma model. Neuro-Oncology, 2021, 23, vi84–vi85.
  • M. Marloye, H. Inam, C. J. Moore, V. Debaille, J. R. Pritchard, M. Gelbcke, F. Meyer, F. Dufrasne and G. Berger, Synthesis, structure and anticancer properties of new biotin- and morpholine-functionalized ruthenium and osmium half-sandwich complexes. J. Biol. Inorg. Chem., 2021, 26, 535-549. pubmed
  • A. P. Nacoulma, M. Compaoré, N. R. Meda, L. Pottier, V. Megalizzi, I. Some and M. Kiendrebeogo, Anti-melanogenesis effect of daniellic acid isolated from Daniellia oliveri (Rolfe) Hutch. & Dalziel (Leguminosae) oleoresin of Burkina Faso, Open J. Med. Chem., 2021, 11, 41-57.
  • S. Oliveira Ribeiro, V. Fontaine, V. Mathieu, A. Zhiri, D. Baudoux, C. Stévigny and F. Souard,  Antibacterial activities of homemade matrices miming essential oils compared to commercial ones. Antibiotics (Basel), 2021, 10, 584. pubmed
2020
  • G. Allende, P. Surriabre, N. Ovando, P. Calle, A. Torrico, J. Villarroel, M. Bossens, V. Fontaine and P. Rodriguez P, Evaluation of the effectiveness of high-risk human papilloma self-sampling test for cervical cancer screening in Bolivia. BMC Infect. Dis., 2020, 20, 259. pubmed
  • G. Berger, P. Frangville and F. Meyer, Halogen bonding for molecular recognition: new developments in materials and biological sciences. Chem. Commun., 2020, 56, 4970-4981. pubmed
  • A. S. Brito, B. Neuhäuser, R. Wintjens, A. M. Marini and M. Boeckstaens, Yeast filamentation signaling is connected to a specific substrate translocation mechanism of the Mep2 transceptor. PLoS Genet. , 2020, 16, e1008634. pubmed
  • A. I. Casas, C. Nogales, H. A. M. Mucke, A. Petraina, A. Cuadrado, A. I. Rojo, P. Ghezzi, V. Jaquet, F. Augsburger, F. Dufrasne, J. Soubhye, S. Deshwal, M. Di Sante, N. Kaludercic, F. Di Lisa and H. H. H. W. Schmidt, On the clinical pharmacology of reactive oxygen species. Pharmacol. Rev., 2020, 72, 801-828. pubmed
  • L. Faïon, K. Djaout, R. Frita, C. Pintiala, F. X. Cantrelle, M. Moune, A. Vandeputte, K. Bourbiaux, C. Piveteau, A. Herledan, A. Biela, F. Leroux, L. Kremer, M. Blaise, A. Tanina, R. Wintjens, X. Hanoulle, B. Déprez, N. Willand, A. R. Baulard and M. Flipo, Discovery of the first Mycobacterium tuberculosis MabA (FabG1) inhibitors through a fragment-based screening. Eur. J. Med. Chem., 2020, 200, 112440. pubmed
  • H. Fouotsa, J. P. Dzoyem, A. M. Lannang, H. G. Stammler, C. D. Mbazoa, M. Luhmer, A. E. Nkengfack, E. Allémann, F. Delie, F. Meyer and N. Sewald, Antiproliferative activity of a new xanthone derivative from leaves of Garcinia nobilis Engl. Nat. Prod. Res., 2020, 1-8. pubmed
  • S. Hocine, G. Berger and S. Hanessian, Design and synthesis of backbone-fused, conformationally constrained morpholine-proline chimeras. J. Org. Chem., 2020, 85, 4237-4247. pubmed
  • J. E. Mbosso Teinkela, X. Siwe Noundou, J. E. Zeh Mimba, F. Meyer, O. M. Tabouguia, J. C. Assob Nguedia, H. C. Hoppe, R. W. C. Krause, R. Wintjens and G. A. B. Azebaze, Compound isolation and biological activities of Piptadeniastrum africanum (hook.f.) Brennan roots. J. Ethnopharmacol., 2020, 255, 112716. pubmed
  • J. Soubhye J, P. Van Antwerpen and F. Dufrasne, A patent review of myeloperoxidase inhibitors for treating chronic inflammatory syndromes (focus on cardiovascular diseases, 2013-​2019). Expert Opin. Ther. Pat., 2020, 30, 595-608. pubmed
  • B. Villemagne, A. Machelart, N. C. Tran, M. Flipo, M. Moune, F. Leroux, C. Piveteau, A. Wohlkönig, R. Wintjens, X. Li, R. Gref, P. Brodin, B. Déprez, A. R. Baulard and N. Willand, Fragment-based optimized EthR inhibitors with in vivo ethionamide boosting activity. ACS Infect. Dis., 2020, 6, 366-378. pubmed
  • R. Wintjens, A. M. Bifani and P. Bifani, Impact of glycan cloud on the B-cell epitope prediction of SARS-CoV-2 Spike protein. NPJ Vaccines, 2020, 5, 81. pubmed
  • D. Yang, D. P. Klebl, S. Zeng, F. Sobott, M. Prévost, P. Soumillion, G. Vandenbussche and V. Fontaine, Interplays between copper and Mycobacterium tuberculosis GroEL1. Metallomics, 2020, 12, 1267-1277. pubmed
  • D. Yang, G. Vandenbussche, D. Vertommen, D. Evrard, R. Abskharon, J. F. Cavalier, G. Berger, S. Canaan, M. S. Khan, S. Zeng, A. Wohlkönig, M. Prévost, P. Soumillion and V. Fontaine, Methyl arachidonyl fluorophosphonate inhibits Mycobacterium tuberculosis thioesterase TesA and globally affects vancomycin susceptibility. FEBS Lett., 2020, 594, 79-93. pubmed
2019
  • Allende G, Surriabre P, Cáceres L, Bellot D, Ovando N, Torrico A, Calle P, Ascarrunz C, Alexander S, Bossens M, Fontaine V & Rodríguez P (2019). Evaluation of the self-sampling for cervical cancer screening in Bolivia. BMC Public Health 19:80. pubmed
  • Berger G, Marloye M & Lawler SE (2019). Pharmacological modulation of the STING pathway for cancer immunotherapy. Trends Mol. Med. 25:412-27. pubmed
  • Kim JH, Mertens RT, Agarwal A, Parkin S, Berger G & Awuah SG (2019). Direct intramolecular carbon(sp2)-nitrogen(sp2) reductive elimination from gold(iii). Dalton Trans. 48:6273-82. pubmed
  • Marloye M, Lawler SE & Berger G (2019). Current patent and clinical status of stimulator of interferon genes (STING) agonists for cancer immunotherapy. Pharm. Pat. Anal. pubmed
  • Prevet H, Moune M, Tanina A, Kemmer C, Herledan A, Frita R, Wohlkönig A, Bourotte M, Villemagne B, Leroux F, Gitzinger M, Baulard AR, Déprez B, Wintjens R, Willand N & Flipo M (2019). A fragment-based approach towards the discovery of N-substituted tropinones as inhibitors of Mycobacterium tuberculosis transcriptional regulator EthR2. Eur. J. Med. Chem. 167:426-38. pubmed
  • Surriabre P, Torrico A, Vargas T, Ugarte F, Rodriguez P & Fontaine V (2019). Assessment of a new low-cost, PCR-based strategy for high-risk human papillomavirus DNA detection for cervical cancer prevention. BMC Infect. Dis. 19:842. pubmed
  • Tanina A, Wohlkönig A, Soror SH, Flipo M, Villemagne B, Prevet H, Déprez B, Moune M, Perée H, Meyer F, Baulard AR, Willand N & Wintjens R (2019). A comprehensive analysis of the protein-ligand interactions in crystal structures of Mycobacterium tuberculosis EthR. Biochim. Biophys. Acta 1867:248-58. pubmed
  • Zeng S, Constant P, Yang D, Baulard A, Lefèvre P, Daffé M, Wattiez R & Fontaine V (2019). Cpn60.1 (GroEL1) contributes to mycobacterial crabtree effect: implications for biofilm formation. Front Microbiol. 10:1149. pubmed
  • Zeng S, Soetaert K, Ravon F, Vandeput M, Bald D, Kauffmann JM, Mathys V, Wattiez R & Fontaine V (2019). Isoniazid bactericidal activity involves electron transport chain perturbation. Antimicrob. Agents Chemother. 63:e01841-18. pubmed
2018
  • Berger G & Lawler SE (2018). Novel non-nucleotidic STING agonists for cancer immunotherapy. Future Med. Chem. 10:2767-2769. pubmed
  • Berger G, Grauwet K, Zhang H, Hussey AM, Nowicki MO, Wang DI, Chiocca EA, Lawler SE & Lippard SJ (2018). Anticancer activity of osmium(VI) nitrido complexes in patient-derived glioblastoma initiating cells and in vivo mouse models. Cancer Letters 416:138-48. pubmed
  • Berger G, Soubhye J, Wintjens R, Robeyns K & Meyer F (2018). Crystal packing and theoretical analysis of halogen- and hydrogen-bonded hydrazones from pharmaceuticals. Evidence of type I and II halogen bonds in extended chains of dichloromethane. Acta Crystallogr. B74:618–27. pubmed
  • Dauchy C, Bautin N, Nseir S, Reboux G, Wintjens R, Le Rouzic O, Sendid B, Viscogliosi E, Le Pape P, Arendrup MC, Gosset P, Fry S & Fréalle E (2018). Emergence of Aspergillus fumigatus azole resistance in azole-naïve patients with chronic obstructive pulmonary disease and their homes. Indoor Air 28:298-306. pubmed
  • Mbosso Teinkela JE, Siwe Noundou X, Nguemfo EL, Meyer F, Wintjens R, Isaacs M, Mpondo Mpondo AE, Hoppe HC, Krause RWM & Azebaze AGB (2018). Biological activities of plant extracts from Ficus elastica and Selaginella vogelli: an antimalarial, antitrypanosomal and cytotoxity evaluation. Saudi J. Biol. Sci. 25:117-22. pubmed
  • Rens C, Ceyssens PJ, Laval F, Lefèvre P, Mathys V, Daffé M & Fontaine V (2018). Aloe emodin reduces phthiodiolone dimycocerosate potentiating vancomycin susceptibility on mycobacteria. Indian J. Microbiol. 58:393-6. pubmed
  • Rens C, Laval F, Wattiez R, Lefèvre P, Dufrasne F, Daffé M & Fontaine V (2018). I3-Ag85 effect on phthiodiolone dimycocerosate synthesis. Tuberculosis 108:93-5. pubmed
  • Sjollema J, Zaat SAJ, Fontaine V, Ramstedt M, Luginbuehl R, Thevissen K, Li J, van der Mei HC & Busscher HJ (2018). In vitro methods for the evaluation of antimicrobial surface designs. Acta Biomater. 70:12-24. pubmed
  • Soubhye J, van Antwerpen P & Dufrasne F (2018). Targeting cytosolic phospholipase A2α for novel anti-inflammatory agents. Curr. Med. Chem. 25:2418-47. pubmed
  • Vernekar AA, Berger G, Czapar AE, Veliz FA, Wang DI, Steinmetz NF & Lippard SJ (2018). Speciation of phenanthriplatin and its analogs in the core of tobacco mosaic virus. J. Am. Chem. Soc. 140:4279-87. pubmed
2017
  • Berger G, Chab-Majdalani I & Hanessian S (2017). Properties of the amide bond involving proline 4,5-methanologues: an experimental and theoretical study. Isr. J. Chem. 57:292–302. doi
  • Blondiaux N, Moune M, Desroses M, Frita R, Flipo M, Mathys V, Soetaert K, Kiass M, Delorme V, Djaout K, Trebosc V, Kemmer C, Wintjens R, Wohlkönig A, Antoine R, Huot L, Hot D, Coscolla M, Feldmann J, Gagneux S, Locht C, Brodin P, Gitzinger M, Déprez B, Willand N & Baulard AR (2017). Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420. Science 355:1206-11. pubmed
  • Chen B, Berger G & Hanessian S (2017) Metal coordination-controlled and bifunctional H-bonded catalysis in stereoselective intramolecular aldol cyclizations toward carbocyclic tertiary β-ketols.  European J. Org. Chem. 1:2631–36. doi
  • Chikh Alard I, Soubhye J, Berger G, Gelbcke M, Spassov S, Amighi K, Goole J & Meyer F (2017). Triple-stimuli responsive polymers with fine tuneable magnetic response. Polym. Chem. 8:2450–56. doi
  • Ngezahayo J, Ribeiro SO, Fontaine V, Hari L, Stévigny C & Duez P (2017). In vitro study of five herbs used against microbial infections in Burundi. Phytother. Res. 31:1571-78. pubmed
  • Soubhye J, Chikh Alard I, Aldib I, Prévost M, Gelbcke M, De Carvalho A, Furtmüller PG, Obinger C, Flemmig J, Tadrent S, Meyer F, Rousseau A, Nève J, Mathieu V, Zouaoui Boudjeltia K, Dufrasne F & Van Antwerpen P (2017). Discovery of novel potent reversible and irreversible myeloperoxidase inhibitors using virtual screening procedure. J. Med. Chem. 60:6563-86. pubmed
  • Surriabre P, Allende G, Prado M, Cáceres L, Bellot D, Torrico A, Ustariz K, Rojas S, Barriga J, Calle P, Villarroel L, Yañez RM, Baay M, Rodriguez P & Fontaine V (2017). Self-sampling for human papillomavirus DNA detection: a preliminary study of compliance and feasibility in BOLIVIA. BMC Womens Health 17:135. pubmed
  • Wohlkönig A, Remaut H, Moune M, Tanina A, Meyer F, Desroses M, Steyaert J, Willand N, Baulard A & Wintjens  R (2017). Structural analysis of the interaction between spiroisoxazoline SMARt-420 and the Mycobacterium tuberculosis repressor EthR2. Biochem. Biophys. Res. Commun. 487:403-8. pubmed
2016
  • Aldib I, Gelbcke M, Soubhye J, Prévost M, Furtmüller PG, Obinger C, Elfving B, Alard IC, Roos G, Delporte C, Berger G, Dufour D, Zouaoui Boudjeltia K, Nève J, Dufrasne F & Van Antwerpen P (2016). Novel bis-arylalkylamines as myeloperoxidase inhibitors: design, synthesis, and structure-activity relationship study. Eur. J. Med. Chem. 123:746-62. pubmed
  • Berger  G, Roeben  K, Soubhye  J, Wintjens  R & Meyer  F (2016). Halogen bonding in multi-connected 1,2,2-triiodo-alkene involving geminal and/or vicinal iodines: a crystallographic and DFT study. CrystEngComm. 18, 683.
  • Bojilova ED, Weyn C, Antoine MH & Fontaine V (2016). Extrachromosomal HPV-16 LCR transcriptional activation by HDACi opposed by cellular differentiation and DNA integration. Oncotarget 7:75526-38. pubmed
  • Chattopadhyay AK, Berger G & Hanessian S (2016). Strategies toward the total synthesis of calyciphylline B-type alkaloids: a computational perspective aided by DFT analysis. J. Org. Chem. 81:5074−86. pubmed
  • Chattopadhyay AK, Ly VL, Jakkepally S, Berger G & Hannessian S (2016). Total synthesis of isodaphlongamine H: a possible biogenetic conundrum. Angew. Chemie Int Ed 55:2577–81. pubmed
  • Levet V, Rosière R, Merlos R, Fusaro L, Berger G, Amighi K & Wautoz N (2016). Development of controlled-release cisplatin dry powders for inhalation against lung cancers. Int. J. Pharm. 515:209–20. pubmed
  • Lim MY, LaMonte G, Lee MCS, Reimer C, Tan BH, Corey V, Tjahjadi BF, Chua A, Nachon M, Wintjens R, Gedeck P, Malleret B, Renia L, Bonamy GMC, Ho PC, Yeung BKS, Chow ED, Lim L, Fidock DA, Diagana TT, Winzeler EA & Bifani P (2016). UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistance genes. Nat. Microbiol. 1:16166. pubmed
  • Marloye M, Berger G, Gelbcke M & Dufrasne F (2016). A survey of the mechanisms of action of anticancer transition metal complexes. Future Med. Chem. 8:2263-86. pubmed
  • Mbosso Teinkela JE, Assob Nguedia JC, Meyer F, Vouffo Donfack E, Lenta Ndjakou B, Ngouela S, Tsamo E, Adiogo D, Guy Blaise Azebaze A & Wintjens R (2016). In vitro antimicrobial and anti-proliferative activities of plant extracts from Spathodea campanulata, Ficus bubu, and Carica papaya. Pharm. Biol. 54:1086-95. pubmed
  • Mbosso Teinkela JE, Siwe Noundou X, Nguemfo EL, Meyer F, Djoukoue A, Van Antwerpen P, Ngouela S, Tsamo E, Mpondo Mpondo EA, Vardamides JC, Azebaze GA & Wintjens R (2016). Identification of compounds with anti-proliferative activity from the wood of Ficus elastica Roxb. ex Hornem. aerial roots. Fitoterapia 112:65-73. pubmed
  • Rens C, Laval F, Daffé M, Denis O, Frita R, Baulard A, Wattiez R, Lefèvre P & Fontaine V (2016). Effects of lipid-lowering drugs on vancomycin susceptibility of mycobacteria. Antimicrob. Agents Chemother. 60:6193-9. pubmed
  • Sá J, Czapla-Masztafiak J, Lipiec E, Kayser Y, Fernandes DL, Szlachetko J, Dufrasne F & Berger G (2016). Resonant X-ray emission spectroscopy of platinum(II) anticancer complexes. Analyst 141:1226-32. pubmed
  • Soubhye J, Aldib I, Delporte C, Prévost M, Dufrasne F & Van Antwerpen P (2016). Myeloperoxidase as a target for the treatment of inflammatory syndromes: mechanisms and structure activity relationships of inhibitors. Curr. Med. Chem. 23:3975-4008. pubmed
  • Soubhye J, Gelbcke M, Van Antwerpen P, Dufrasne F, Boufadi MY, Nève J, Furtmüller PG, Obinger C, Zouaoui Boudjeltia K & Meyer F (2016). From dynamic combinatorial chemistry to in vivo evaluation of reversible and irreversible myeloperoxidase inhibitors. ACS Med. Chem. Lett. 8:206-10. pubmed
  • Soubhye J, Meyer F, Furtmüller P, Obinger C, Dufrasne F & Van Antwerpen P (2016). Characterization of chemical features of potent myeloperoxidase inhibitors. Future Med. Chem. 8:1163-77. pubmed
  • Wintjens R, Bozon D, Belabbas K, MBou F, Girardet JP, Tounian P, Jolly M, Boccara F, Cohen A, Karsenty A, Dubern B, Carel JC, Azar-Kolakez A, Feillet F, Labarthe F, Gorsky AM, Horovitz A, Tamarindi C, Kieffer P, Lienhardt A, Lascols O, Di Filippo M & Dufernez F (2016). Global molecular analysis and APOE mutations in a cohort of autosomal dominant hypercholesterolemia patients in France. J. Lipid Res. 57:482-91. pubmed
  • Zater H, Huet J, Fontaine V, Benayache S, Stévigny C, Duez P & Benayache F (2016). Chemical constituents, cytotoxic, antifungal and antimicrobial properties of Centaurea diluta Ait. subsp. algeriensis (Coss. & Dur.) Maire. Asian Pac. J. Trop. Med. 9:554-61. pubmed
Collaborations
National
  • J. Cornil, Laboratory of Chemistry for Novel Materials, UMons, Mons
  • P. Dubois, Center of Innovation and Research in Materials and Polymers (CIRMAP), UMons, Mons
  • R. Lazzaroni, Laboratory of Chemistry for Novel Materials, UMons, Mons
  • T. Leyssens, Molecular Chemistry, Materials and Catalysis, UCL, Louvain-la-Neuve
  • V. Mathys, Belgian Reference Laboratory for “Tuberculosis and Mycobacteria” , Sciensano
  • J. M. Raquez,Center of Innovation and Research in Materials and Polymers (CIRMAP), UMons, Mons
  • K. Robeyns, Institute of Condensed Matter and Nanosciences (IMCN), UCL, Louvain-la-Neuve
  • G. Roos, General Chemistry, Vrije Universiteit Brussel, Brussels
  • P. Soumillion, Institut des Sciences de la Vie, UCL, Louvain-la-Neuve
  • C. Vande Velde, Advanced Reactor Technology, Faculty of Applied Engineering, University of Antwerp, Hoboken
  • K. Van Hecke, Inorganic and Physical Chemistry, Ghent University, Ghent
  • T. Verbiest, Molecular Imaging and Photonic, KUL, Leuven
  • D. Vertommen, Institut de Duve, UCL, Louvain-la-Neuve
  • R. Wattiez, Department of Proteomics and Microbiology, UMons, Mons
Europe
  • C. Abbadie, Initiation of Epithelial Cancers, Institut Pasteur de Lille, France
  • D. Bald, Faculty of Sciences, Structural Biology, Vrij University, Amsterdam, The Netherlands
  • A. Baulard, Institut Pasteur de Lille, Centre Infection and Immunity of Lille, France
  • N. Bayan, I2BC Institut de Biologie Cellulaire Intégrative, Université Paris Sud, France
  • M. Beniddir, Fac. Pharmacie, Biocys, Pharmacognosie, Université de Paris-Saclay, France
  • P. Bertrand, UMR 7285 - Institut de Chimie des Milieux et Matériaux de Poitiers (IC2MP), Université de Poitiers, France
  • S. Bombard, INSERM, Unité INSERM UMR-S 1007, Homéostasie cellulaire et cancer, Université Paris Descartes, France
  • P. Brodin, Institut Pasteur de Lille, Centre Infection and Immunity of Lille, France
  • S. Canaan, Laboratoire d'Ingénierie des Systèmes Macromoléculaires, Marseilles, France
  • S. Clément, Institut Charles Gerhardt, Université de Montpellier 2, CMOS, Montpellier, France
  • B. Crousse, Laboratoire BioCIS associé au CNRS, Centre d’Etudes Pharmaceutiques, France
  • M. Daffé, Institute of Pharmacology and Structural Biology, University of Toulouse, France
  • B. Elfving, Center for psykiatrisk forskning, Århus Universitetshospital, Risskov, Denmark
  • J. Flemmig, Institute for Medical Physics and Biophysics, Medical Faculty, University of Leipzig, Germany
  • E. Kandiah, CM01 beamline, ESRF, Grenoble, France
  • Y. Kayser, Paul Scherrer Institute (PSI), Villigen, Switzerland
  • V. Laudenbach, Faculté de Médecine, Université de Rouen, France
  • P. Legrand, PX1 beamline, SOLEIL synchrotron, Gif-sur-Yvette, France
  • P. Metrangolo, Dipartimento di Chimica, Materiali ed Ingegneria Chimica "G. Natta", Milano, Italy
  • C. Obinger, Department of Chemistry, University of Natural Resources and Applied Life Sciences, Vienna, Austria
  • G. Resnati, Dipartimento di Chimica, Materiali ed Ingegneria Chimica "G. Natta", Milano, Italy
  • J. Sa, Department of Chemistry - Ångström Laboratory, Physical Chemistry , Uppsala Universitet, Uppsala, Sweden
  • H. Sirringhaus, Cavendish Laboratory, University of Cambridge, UK
  • F. Sobott, The Astbury Centre for Structural Molecular Biology, University of Leeds, UK
  • P. Supply, Institut Pasteur de Lille, Centre Infection and Immunity of Lille, France
  • J. Szlachetko, Institute of Physics, Jan Kochanowski University in Kielce, Poland
  • A. van der Lee, Institut Européen des Membranes, CNRS - UMR 5635, Université Montpellier 2, France
  • F. Vidal, Laboratoire de Physicochimie des Polymères et des Interfaces, Université de Cergy Pontoise, France
  • A. Wach, Swiss Light Source, Villigen, Switzerland
  • N. Willand, U1177 Drugs and Molecules for Living Systems, Université de Lille, France
Africa
  • Y. Boufadi, Université Mostaganem, Algeria
  • J.-B. Lumbu, Fac. Pharmacie, Drpt. Chimie Organique, Université de Lubumbashi, RDC
  • J. E. T. Mbosso, Faculté de Médecine et des Sciences Pharmaceutiques (FMSP), Université de Douala, Cameroon
North America
  • S. Awuah, Department of Chemistry, University of Kentucky, Lexington, KY, USA
  • S. Hanessian, Département de Chimie, Université de Montréal, Montréal, Canada
  • S. E. Lawler, Harvey Cushing Neuro-Oncology Laboratories, Harvard Medical School, Boston, Massachusetts, USA
  • B. Pentelute, Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA
South America
  • P. Rodriguez, Universidad Mayor San Simon, Faculty of Medicine, Cochabamba, Bolivia
Asia
  • P. Bifani, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
  • S. Zeng, T. Zhang, Guangzhou Institute of Biomedicine and Health, China
Australia


 
Thesis

2021

Mickael MARLOYE "Rationally designed ruthenium and osmium pseudo-octahedral complexes with original metabolic and antitumor properties"

Rana AL NAKIB "Tailoring properties of thermoplastic polyurethanes targeting biomedical applications"

2020

Abdalkarim TANINA "Structural analysis of transcription factors involved in Mycobacterium tuberculosis mycolic acid biosynthesis"

Gustavo ALLENDE "Evaluation of hrHPV testing on a vaginal specimen collected by woman her-self in Bolivia"

Dong YANG "Structural and functional characterization of proteins involved in PDIM biosynthesis in Mycobacterium tuberculosis"

2019

Ekaterina BOJILOVA "Impact of histone deacetylase inhibitors on the HPV-16 transcriptional activity and genomic integration"

Pedro SURRIABRE "Développement d’une stratégie adaptée à la situation bolivienne pour la détection des papillomavirus humains de haut risque"

Sheng ZENG "Mycobacterium bovis BCG chaperonin 60.1 contributes to adaptations under stresses : implication for escaping isoniazid bactericidal mechanism and for mycobacterial biofilm growth"

2018

Ibaa CHIKH ALARD “Development of novel multi-responsive materials characterized by potential controlled release properties”

• Céline RENS "Etude de la régulation transcriptionnelle de gènes nécessaires à la synthèse ou au transport de PDIM chez Mycobacterim bovis BCG et Mycobacterium tuberculosis"
Contact
Université Libre de Bruxelles
Plaine campus, CP 206/04
Building BC, level 4
Boulevard du Triomphe, access 2
1050 Brussels
Belgium
Emails:
        unit mbmc@ulb.be
        microbiology veronique.fontaine@ulb.be
        chemistry franck.meyer@ulb.be and dufrasne@ulb.be
        Medicinal Chemistry gilles.berger@ulb.be
        structural biology rene.wintjens@ulb.be
Mis à jour le 13 septembre 2022