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Véronique Fontaine
Research in Drug Development (RD3)
Microbiology, Bioorganic and Macromolecular Chemistry
ContactResearch activities
The study of microorganisms, their virulence factors and drugs able to target them. My two main axes of research are human papillomaviruses (HPV) and mycobacteria. In virology, we are currently studying the regulation of the HPV-16 early gene expression and viral genome integration by various endogenic and iatrogenic factors. In mycobacteriology, our goals are to better characterize proteins involved in the synthesis of the waxy cell wall and to identify compounds able to inhibit the synthesis of this wall in order to target multidrug resistant Mycobacterium tuberculosis.
Top ten recent articles
Easy, Flexible and Standardizable Anti-Nascent Biofilm Activity Assay to Assess Implant Materials
Vanheuverzwijn, J., Maillard, E.-E., Mahat, A., Fowler, L., Monteyne, D., Bonnaud, L., Landercy, N., Hemberg, A., Janković, A., Meyer, F., Mišković-Stanković, V., Stevanović, M., Mirica, C., Pérez-Morga, D., Luginbuehl, R., Combes, C., Furtos, G., & Fontaine, V. (2023). Easy, Flexible and Standardizable Anti-Nascent Biofilm Activity Assay to Assess Implant Materials. Microorganisms, 11(4), 1023. doi:10.3390/microorganisms11041023
Synthesis and biological activity of iron(II), iron(III), nickel(II), copper(II) and zinc(II) complexes of aliphatic hydroxamic acids
Sow, I. S., Gelbcke, M., Meyer, F., Vandeput, M., Marloye, M., Basov, S., Van Bael, M., Berger, G., Robeyns, K., Hermans, S., Yang, D., Fontaine, V., & Dufrasne, F. (2023). Synthesis and biological activity of iron(II), iron(III), nickel(II), copper(II) and zinc(II) complexes of aliphatic hydroxamic acids. Journal of coordination chemistry, 1-30. doi:10.1080/00958972.2023.2166407
The Mycobacterium bovis BCG GroEL1 Contributes to Isoniazid Tolerance in a Dormant-Like State Model
Zeng, S., Yang, D., Rens, C., & Fontaine, V. (2023). The Mycobacterium bovis BCG GroEL1 Contributes to Isoniazid Tolerance in a Dormant-Like State Model. Microorganisms, 11, 286, 286. doi:10.3390/microorganisms11020286
Design of Thermoplastic Polyurethanes with Conferred Antibacterial, Mechanical, and Cytotoxic Properties for Catheter Application
Al Nakib, R., Toncheva, A., Fontaine, V., Vanheuverzwijn, J., Raquez, J.-M., & Meyer, F. (2022). Design of Thermoplastic Polyurethanes with Conferred Antibacterial, Mechanical, and Cytotoxic Properties for Catheter Application. ACS Applied Bio Materials, 5(12), 5532-5544. doi:10.1021/acsabm.2c00531
Assessing Barriers Encountered by Women in Cervical Cancer Screening and Follow-Up Care in Urban Bolivia, Cochabamba
Bensemmane, S., Loayza Villarroel, K., Montaño, K., Louati, E., Ascarrunz, C., Rodriguez, P., Fontaine, V., & Laokri, S. (2022). Assessing Barriers Encountered by Women in Cervical Cancer Screening and Follow-Up Care in Urban Bolivia, Cochabamba. Healthcare (Switzerland), 10(9), 1604. doi:10.3390/healthcare10091604
In vitro and in vivo local tolerability of a synergistic anti-tuberculosis drug combination intended for pulmonary delivery
Ravon, F., Menchi, E., Lambot, C., Sahar, A. K., Chraibi, S., Remmelink, M., Fontaine, V., & Wauthoz, N. (2022). In vitro and in vivo local tolerability of a synergistic anti-tuberculosis drug combination intended for pulmonary delivery. Journal of applied toxicology, 1-14.
Pyrrovobasine, hybrid alkylated pyrraline monoterpene indole alkaloid pseudodimer discovered using a combination of mass spectral and NMR-based machine learning annotations
Fouotsa, H., Mkounga, P., Lannang, A. M., Vanheuverzwijn, J., Zhou, Z., Leblanc, K., Rharrabti, S., Nkengfack, A. E., Gallard, J.-F., Fontaine, V., Meyer, F., Poupon, E., Le Pogam, P., & Beniddir, M. (2022). Pyrrovobasine, hybrid alkylated pyrraline monoterpene indole alkaloid pseudodimer discovered using a combination of mass spectral and NMR-based machine learning annotations. Organic & biomolecular chemistry, 20(1), 98-105. doi:10.1039/D1OB01791H
Thermoplastic polyurethanes for biomedical application: A synthetic, mechanical, antibacterial, and cytotoxic study
Al Nakib, R., Toncheva, A., Fontaine, V., Vanheuverzwijn, J., Raquez, J.-M., & Meyer, F. (2022). Thermoplastic polyurethanes for biomedical application: A synthetic, mechanical, antibacterial, and cytotoxic study. Journal of applied polymer science, 139(4), 51666. doi:10.1002/app.51666
Voatriafricanines A and B, Trimeric Vobasine-Aspidosperma-Aspidosperma Alkaloids from Voacanga africana
Fouotsa, H., Le Pogam, P., Mkounga, P., Lannang, A. M., Bernadat, G., Vanheuverzwijn, J., Zhou, Z., Leblanc, K., Rharrabti, S., Nkengfack, A. E., Gallard, J.-F., Fontaine, V., Meyer, F., Poupon, E., & Beniddir, M. (2021). Voatriafricanines A and B, Trimeric Vobasine-Aspidosperma-Aspidosperma Alkaloids from Voacanga africana. Journal of natural products. doi:10.1021/acs.jnatprod.1c00812
Antibacterial Activities of Homemade Matrices Miming Essential Oils Compared to Commercial Ones
Oliveira Ribeiro, S., Fontaine, V., Mathieu, V., Abdesselam, Z., Dominique, B., Caroline, S., & Souard, F. (2021). Antibacterial Activities of Homemade Matrices Miming Essential Oils Compared to Commercial Ones. Antibiotics, 10(5), 584. doi:10.3390/antibiotics10050584
Career
- Professor at the Faculty of Pharmacy (ULB) (2009-)
- Scientist assistant for the Defense Ministry, DLD-Bio, Belgium(2009).
- Head of the Papillomavirus Unit at the Institut Pasteur de Bruxelles, Belgium (2004-2008)
- Post-doctoral fellow at the University of Amsterdam, AMC, Department of Virology, The Netherlands (1997-1998, 2000)
- Post-doctoral fellow at the CLB, Department of Autoimmune Diseases, The Netherlands (1995-1996)
- Post-doctoral fellow at the Institut Pasteur de Bruxelles, Department of Virology, Belgium (1993-1994)
- Post-doctoral fellow at the Imperial Cancer Research Fund, Department of Molecular Biology, United Kingdom (1992-1993)PhD in Medical Biology "Identification, by mutagenesis, of sequences required for the interaction of the human IL-6 with its receptor"Faculty of Medicine (ULB)(1992)
- Teaching qualification (ULB)(1991)
- PhD student - Institut Pasteur de Bruxelles (ULB)(1987-1992)