2023
  • H. Parinaz, O. V. Okoro, M. Hajiabbas, M. Hamidi, L. Nie, V. Megalizzi, P. Musonge, G. Dodi and A. Shavandi, Chemical composition, antioxidant activity and cytocompatibility of polyphenolic compounds extracted from food industry apple waste: potential in biomedical application, Molecules, 2023, 28, 675. pubmed
  • S. Zeng, D. Yang, C. Rens and V. Fontaine, The Mycobacterium bovis BCG GroEL1 contributes to isoniazid tolerance in a dormant-like state model, Microorganisms, 2023, 11, 286. doi: 10.3390/microorganisms11020286
2022
  • R. Al Nakib, A. Toncheva, V. Fontaine, J. Vanheuverzwijn, J. M. Raquez and F. Meyer, Design of thermoplastic polyurethanes with conferred antibacterial, mechanical and cytotoxic properties for catheter application, ACS Appl. Bio Mater., 2022, 5, 5532-5544. pubmed
  • A. G. N. Avila, B. Deschênes-Simard, J. E. Arnold, M. Morency, D. Chartrand, T. Maris, G. Berger, G. M. Day, S. Hanessian and J. D. Wuest, Surprising chemistry of 6-azidotetrazolo[5,1- a]phthalazine: what a purported natural product reveals about the polymorphism of explosives, J. Org. Chem., 2022, 87, 6680-6694. pubmed
  • R. Benabbes, S. Ouahhoud, M. Moueqqit, M. Addi, C. Hano, C. Delporte, A. Nacoulma and V. Megalizzi, The major stilbene compound accumulated in the roots of a resistant variety of Phoenix dactylifera L. activates proteasome for a path in anti-aging strategy, Cells, 2022, 12, 71. pubmed
  • S. Bensemmane, K. Loayza Villarroel, K. Montaño, E. Louati, C. Ascarrunz, P. Rodriguez, V.  Fontaine and S. Laokri, Assessing barriers encountered by women in cervical cancer screening and follow-up care in urban Bolivia, Cochabamba. Healthcare, 2022, 10, 1604. pubmed
  • G. Berger, E. H. Knelson, J. L. Jimenez-Macias, M. O. Nowicki, S. Han, E. Panagioti, P. H. Lizotte, K. Adu-Berchie, A. Stafford, N. Dimitrakakis, L. Zhou, E. A. Chiocca, D. J. Mooney, D. A. Barbie and S. E. Lawler,  STING activation promotes robust immune response and NK cell-mediated tumor regression in glioblastoma models. Proc. Natl. Acad. Sci. USA, 2022, 119, e2111003119. pubmed
  • T. Demaret, R. Wintjens, G. Sana, J. Docquir, F. Bertin, C. Ide, O. Monestier, D. Karadurmus, V. Benoit and I. Maystadt, Case report: inactivating PTH/PTHrP signaling disorder type 1 presenting with PTH resistance. Front. Endocrinol. (Lausanne), 2022, 13, 928284. pubmed
  • F. Dufrasne, Baloxavir marboxil : an original new drug against influenza. Pharmaceuticals, 2022, 15, 28. pubmed
  • M. Flipo, R. Frita, M. Bourotte, M. S. Martínez-Martínez, M. Boesche, G. W. Boyle, G. Derimanov, G. Drewes, P. Gamallo, S. Ghidelli-Disse, S. Gresham, E. Jiménez, J. de Mercado, E. Pérez-Herrán, E. Porras-De Francisco, J. Rullas, P. Casado, F. Leroux, C. Piveteau, M. Kiass, V. Mathys, K. Soetaert, V. Megalizzi, A. Tanina, R. Wintjens, R. Antoine, P. Brodin, V. Delorme, M. Moune, K. Djaout, S. Slupek, C. Kemmer, M. Gitzinger, L. Ballell, A. Mendoza-Losana, S. Lociuro, B. Deprez, D. Barros-Aguirre, M. J. Remuiñán, N. Willand and A. R. Baulard, The small-molecule SMARt751 reverses Mycobacterium tuberculosis resistance to ethionamide in acute and chronic mouse models of tuberculosis. Sci. Transl. Med., 2022, 14, eaaz6280. pubmed
  • H. Fouotsa, P. Mkounga, A. M. Lannang, J. Vanheuverzwijn, Z. Zhou, K. Leblanc, S. Rharrabti, A. E. Nkengfack, J. F. Gallard, V. Fontaine, F. Meyer, E. Poupon, P. Le Pogam and M. A. Beniddir, Pyrrovobasine, hybrid alkylated pyrraline monoterpene indole alkaloid pseudodimer discovered using a combination of mass spectral and NMR-based machine learning annotations. Org. Biomol. Chem., 2022, 20, 98-105. pubmed
  • S. Hocine, G. Berger, K. N. Houk and S. Hanessian, Catalytic properties of 4, 5-bridged proline methano-and ethanologues in the Hajos–Parrish intramolecular aldol reaction. Org. Chem. Front. , 2022, 9, 649-659.
  • J. L. Jimenez-Macias, Y. C. Lee, T. Finkelberg, G. Berger, M. Nowicki, C. F. Cho, B. Fedeles, A. Loas, B. Penetelute and S. E. Lawler, Pt (IV)-M13, a blood-brain-barrier penetrant macrocyclic peptide-platinum (IV) conjugate, leads to enhanced drug uptake and efficacy in murine glioblastoma models. Cancer Res., 2022, 82, 5329.
  • J. L. Jimenez-Macias, Y.-C. Lee, E. Miller, T. Finkelberg, M. Zdioruk, G. Berger, C. E. Farquhar, M. O. Nowicki, C.-F. Cho, B. I. Fedeles, A. Loas, B. L. Pentelute, and S. E. Lawler, A Pt(IV)-conjugated brain penetrant macrocyclic peptide shows pre-clinical efficacy in glioblastoma, J. Control. Release, 2022, 352, 623-636. pubmed
  • M. Marloye, H. Inam, C. J. Moore, T. R. Mertens, A. Ingels, M. Koch, M. O. Nowicki, V. Mathieu, J. R. Pritchard, S. G. Awuah, S. E. Lawler, F. Meyer, F. Dufrasne and G. Berger, Self-assembled ruthenium and osmium nanosystems display a potent anticancer profile by interfering with metabolic activity. Inorg. Chem. Front., 2022, 9, 2594-2607.
  • R. T. Mertens, C. E. Greif, J. T. Coogle, G. Berger, S. Parkin, M. D. Watson and S. G. Awuah, Stable Au(I) catalysts for oxidant-free C-H functionalization with iodoarenes. J. Catal., 2022, 408, 109-114. pubmed
  • F. Ravon, E. Menchi, C. Lambot, S. Al Kattar, S. Chraibi, M. Remmelink, V. Fontaine and N. Wauthoz, In vitro and in vivo local tolerability of a synergistic anti-tuberculosis drug combination intended for pulmonary delivery. J. Appl. Toxicol., 2022, 43, 298-311. pubmed
  • M. Sawant, S. Benamrouz-Vanneste, D. Meloni, N. Gantois, G. Even, K. Guyot, C. Creusy, E. Duval, R. Wintjens, J. B. Weitzman, M. Chabe, E. Viscogliosi and G. Certad, Putative SET-domain methyltransferases in Cryptosporidium parvum and histone methylation during infection, Virulence, 2022, 13, 1632-1650. pubmed
  • L. Schawe, B. Raude, J. C. Carstens, I. Hinterseher, R. D. Hein, S. Omran, G. Berger, N. A. Hering, M. Buerger, A. Greiner and J. P. Frese, Effect of Revascularization on Intramuscular Vascular Endothelial Growth Factor Levels in Peripheral Arterial Disease. Biomedicines, 2022, 10, 471. pubmed
2021
  • G. Battisti, R. Wintjens, A. Decottignies, A. Merhi, C. Fervaille, E. Sokal, D. Karadurmus, V. Benoit, A. Claessens, J. P. Martinet, B. Martiat, P. Kinzinger and I. Maystadt, Child to adulthood clinical description of MDPL syndrome due to a novel variant in POLD1, Eur. J. Med. Genet., 2021, 64, 104333. pubmed
  • G. Berger, A. Wach, S. Jacinto and J. Szlachetko, Reduction mechanisms of anticancer osmium(VI) complexes revealed by atomic telemetry and theoretical calculations. Inorg. Chem., 2021, 60, 6663-6671. pubmed
  • H. Fouotsa, P. Le Pogam, P. Mkounga, A. M. Lannang, G. Bernadat, J. Vanheuverzwijn, Z. Zhou, K. Leblanc, S. Rharrabti, A. E. Nkengfack, J. F. Gallard, V. Fontaine, F. Meyer, E. Poupon and M. A. Beniddir, Voatriafricanines A and B, trimeric vobasine-aspidosperma-aspidosperma alkaloids from Voacanga africana. J. Nat. Prod., 2021, 84, 2755-2761. pubmed
  • H. Fouotsa, J. P. Dzoyem, A. M. Lannang, H. G. Stammler, C. D. Mbazoa, M. Luhmer, A. E. Nkengfack, E. Allémann, F. Delie, F. Meyer and N. Sewald, Antiproliferative activity of a new xanthone derivative from leaves of Garcinia nobilis Engl. Nat. Prod. Res. , 2021, 35, 5604-5611. pubmed
  • P. Frangville, S. Kumar, M. Gelbcke, K. Van Hecke and F. Meyer, Stimuli responsive materials supported by orthogonal hydrogen and halogen bonding or I···alkene interaction. Molecules, 2021, 26, 7586. pubmed
  • T. Kouamé, T. Okpekon, N. F. Bony, S. Ferron, D. Bonnaffé, J. Vanheuverzwijn, Z. Zhou, V. Fontaine, A. D. N’Tamon, J. F. Gallard, K. Leblanc, J. C. Jullian, C. Miel, P. Champy, M. A. Beniddir and P. Le Pogam, Anticipate, target and characterize: MS²-anticipated C glycosylflavones from Erythrococca anomala. Planta Medica International Open, 2021, 8, e131-e142.
  • J. J. Macias, Y. C. Lee, T. Finkelberg, M. Zdioruk, G. Berger, M. Nowicki, C. F. Cho, B. Fedeles, A. Loas, B. Pentelute and S. E. Lawler, Assessment of brain penetrance, biodistribution, and efficacy of platinum(IV)-conjugated fluorinated macrocyclic cell-penetrating peptides in a murine glioblastoma model. Neuro-Oncology, 2021, 23, vi84–vi85.
  • M. Marloye, H. Inam, C. J. Moore, V. Debaille, J. R. Pritchard, M. Gelbcke, F. Meyer, F. Dufrasne and G. Berger, Synthesis, structure and anticancer properties of new biotin- and morpholine-functionalized ruthenium and osmium half-sandwich complexes. J. Biol. Inorg. Chem., 2021, 26, 535-549. pubmed
  • A. P. Nacoulma, M. Compaoré, N. R. Meda, L. Pottier, V. Megalizzi, I. Some and M. Kiendrebeogo, Anti-melanogenesis effect of daniellic acid isolated from Daniellia oliveri (Rolfe) Hutch. & Dalziel (Leguminosae) oleoresin of Burkina Faso, Open J. Med. Chem., 2021, 11, 41-57.
  • S. Oliveira Ribeiro, V. Fontaine, V. Mathieu, A. Zhiri, D. Baudoux, C. Stévigny and F. Souard,  Antibacterial activities of homemade matrices miming essential oils compared to commercial ones. Antibiotics (Basel), 2021, 10, 584. pubmed
2020
  • G. Allende, P. Surriabre, N. Ovando, P. Calle, A. Torrico, J. Villarroel, M. Bossens, V. Fontaine and P. Rodriguez, Evaluation of the effectiveness of high-risk human papilloma self-sampling test for cervical cancer screening in Bolivia, BMC Infect. Dis., 2020, 20, 259. pubmed
  • G. Berger, P. Frangville and F. Meyer, Halogen bonding for molecular recognition: new developments in materials and biological sciences, Chem. Commun., 2020, 56, 4970-4981. pubmed
  • A. S. Brito, B. Neuhäuser, R. Wintjens, A. M. Marini and M. Boeckstaens, Yeast filamentation signaling is connected to a specific substrate translocation mechanism of the Mep2 transceptor, PLoS Genet. , 2020, 16, e1008634. pubmed
  • A. I. Casas, C. Nogales, H. A. M. Mucke, A. Petraina, A. Cuadrado, A. I. Rojo, P. Ghezzi, V. Jaquet, F. Augsburger, F. Dufrasne, J. Soubhye, S. Deshwal, M. Di Sante, N. Kaludercic, F. Di Lisa and H. H. H. W. Schmidt, On the clinical pharmacology of reactive oxygen species, Pharmacol. Rev., 2020, 72, 801-828. pubmed
  • L. Faïon, K. Djaout, R. Frita, C. Pintiala, F. X. Cantrelle, M. Moune, A. Vandeputte, K. Bourbiaux, C. Piveteau, A. Herledan, A. Biela, F. Leroux, L. Kremer, M. Blaise, A. Tanina, R. Wintjens, X. Hanoulle, B. Déprez, N. Willand, A. R. Baulard and M. Flipo, Discovery of the first Mycobacterium tuberculosis MabA (FabG1) inhibitors through a fragment-based screening, Eur. J. Med. Chem., 2020, 200, 112440. pubmed
  • H. Fouotsa, J. P. Dzoyem, A. M. Lannang, H. G. Stammler, C. D. Mbazoa, M. Luhmer, A. E. Nkengfack, E. Allémann, F. Delie, F. Meyer and N. Sewald, Antiproliferative activity of a new xanthone derivative from leaves of Garcinia nobilis Engl, Nat. Prod. Res., 2020, 1-8. pubmed
  • S. Hocine, G. Berger and S. Hanessian, Design and synthesis of backbone-fused, conformationally constrained morpholine-proline chimeras. J. Org. Chem., 2020, 85, 4237-4247. pubmed
  • J. E. Mbosso Teinkela, X. Siwe Noundou, J. E. Zeh Mimba, F. Meyer, O. M. Tabouguia, J. C. Assob Nguedia, H. C. Hoppe, R. W. C. Krause, R. Wintjens and G. A. B. Azebaze, Compound isolation and biological activities of Piptadeniastrum africanum (hook.f.) Brennan roots, J. Ethnopharmacol., 2020, 255, 112716. pubmed
  • J. Soubhye, P. Van Antwerpen and F. Dufrasne, A patent review of myeloperoxidase inhibitors for treating chronic inflammatory syndromes (focus on cardiovascular diseases, 2013-​2019), Expert Opin. Ther. Pat., 2020, 30, 595-608. pubmed
  • B. Villemagne, A. Machelart, N. C. Tran, M. Flipo, M. Moune, F. Leroux, C. Piveteau, A. Wohlkönig, R. Wintjens, X. Li, R. Gref, P. Brodin, B. Déprez, A. R. Baulard and N. Willand, Fragment-based optimized EthR inhibitors with in vivo ethionamide boosting activity, ACS Infect. Dis., 2020, 6, 366-378. pubmed
  • R. Wintjens, A. M. Bifani and P. Bifani, Impact of glycan cloud on the B-cell epitope prediction of SARS-CoV-2 Spike protein. NPJ Vaccines, 2020, 5, 81. pubmed
  • D. Yang, D. P. Klebl, S. Zeng, F. Sobott, M. Prévost, P. Soumillion, G. Vandenbussche and V. Fontaine, Interplays between copper and Mycobacterium tuberculosis GroEL1, Metallomics, 2020, 12, 1267-1277. pubmed
  • D. Yang, G. Vandenbussche, D. Vertommen, D. Evrard, R. Abskharon, J. F. Cavalier, G. Berger, S. Canaan, M. S. Khan, S. Zeng, A. Wohlkönig, M. Prévost, P. Soumillion and V. Fontaine, Methyl arachidonyl fluorophosphonate inhibits Mycobacterium tuberculosis thioesterase TesA and globally affects vancomycin susceptibility, FEBS Lett., 2020, 594, 79-93. pubmed
2019
  • G. Allende, P. Surriabre, L. Cáceres, D. Bellot, N. Ovando, A. Torrico, P. Calle, C. Ascarrunz, S. Alexander, M. Bossens, V. Fontaine and P. Rodríguez, Evaluation of the self-sampling for cervical cancer screening in Bolivia, BMC Public Health, 2019, 19, 80. pubmed
  • G. Berger, M. Marloye and S. E. Lawler, Pharmacological modulation of the STING pathway for cancer immunotherapy, Trends Mol. Med., 2019, 25, 412-27. pubmed
  • J. H. Kim, R. T. Mertens, A. Agarwal, S. Parkin, G. Berger and S. G. Awuah, Direct intramolecular carbon(sp2)-nitrogen(sp2) reductive elimination from gold(iii). Dalton Trans., 2019, 48, 6273-6282. pubmed
  • M. Marloye, S. E. Lawler and G. Berger, Current patent and clinical status of stimulator of interferon genes (STING) agonists for cancer immunotherapy, Pharm. Pat. Anal., 2019, pubmed
  • H. Prevet, M. Moune, A. Tanina, C. Kemmer, A. Herledan, R. Frita, A. Wohlkönig, M. Bourotte, B. Villemagne, F. Leroux, M. Gitzinger, A. R. Baulard, B. Déprez, R. Wintjens, N. Willand and M. Flipo, A fragment-based approach towards the discovery of N-substituted tropinones as inhibitors of Mycobacterium tuberculosis transcriptional regulator EthR2, Eur. J. Med. Chem. , 2019,167, 426-438. pubmed
  • P. Surriabre, A. Torrico, T. Vargas, F. Ugarte, P. Rodriguez and V. Fontaine, Assessment of a new low-cost, PCR-based strategy for high-risk human papillomavirus DNA detection for cervical cancer prevention, BMC Infect. Dis., 2019, 19, 842. pubmed
  • A. Tanina, A. Wohlkönig, S. H. Soror, M. Flipo, B. Villemagne, H. Prevet, B. Déprez, M. Moune, H. Perée, F. Meyer, A. R. Baulard, N. Willand and R. Wintjens, A comprehensive analysis of the protein-ligand interactions in crystal structures of Mycobacterium tuberculosis EthR, Biochim. Biophys. Acta , 2019, 1867, 248-258. pubmed
  • S. Zeng, P. Constant, D. Yang, A. R. Baulard, P. Lefèvre, M. Daffé, R. Wattiez and V. Fontaine, Cpn60.1 (GroEL1) contributes to mycobacterial crabtree effect: implications for biofilm formation, Front Microbiol., 2019, 10, 1149. pubmed
  • S. Zeng, K. Soetaert, F. Ravon, M. Vandeput, D. Bald, J. M. Kauffmann, V. Mathys, R. Wattiez and V. Fontaine, Isoniazid bactericidal activity involves electron transport chain perturbation, Antimicrob. Agents Chemother., 2019, 63, e01841-18. pubmed
2018
  • G. Berger and S. E. Lawler, Novel non-nucleotidic STING agonists for cancer immunotherapy, Future Med. Chem., 2018, 10, 2767-2769. pubmed
  • G. Berger, K. Grauwet, H. Zhang, A. M. Hussey, M. O. Nowicki, D. I. Wang, E. A. Chiocca, S. E. Lawler and S. J. Lippard, Anticancer activity of osmium(VI) nitrido complexes in patient-derived glioblastoma initiating cells and in vivo mouse models, Cancer Letters , 2018, 416, 138-148. pubmed
  • G. Berger, J. Soubhye, R. Wintjens, K. Robeyns and F. Meyer, Crystal packing and theoretical analysis of halogen- and hydrogen-bonded hydrazones from pharmaceuticals. Evidence of type I and II halogen bonds in extended chains of dichloromethane, Acta Crystallogr. , 2018, B74, 618–627. pubmed
  • C. Dauchy, N. Bautin, S. Nseir, G. Reboux, R. Wintjens, O. Le Rouzic, B. Sendid, E. Viscogliosi, P. Le Pape, M. C. Arendrup, P. Gosset, S. Fry and E. Fréalle, Emergence of Aspergillus fumigatus azole resistance in azole-naïve patients with chronic obstructive pulmonary disease and their homes, Indoor Air , 2018, 28, 298-306. pubmed
  • J. E. Mbosso Teinkela, X. Siwe Noundou, E. L. Nguemfo, F. Meyer, R. Wintjens, M. Isaacs, A. E. Mpondo, H. C. Hoppe, R. W. M. Krause and A. G. B. Azebaze, Biological activities of plant extracts from Ficus elastica and Selaginella vogelli: an antimalarial, antitrypanosomal and cytotoxity evaluation, Saudi J. Biol. Sci., 2018, 25, 117-122. pubmed
  • C. Rens, P. J. Ceyssens, F. Laval, P. Lefèvre, V. Mathys, M. Daffé and V. Fontaine, Aloe emodin reduces phthiodiolone dimycocerosate potentiating vancomycin susceptibility on mycobacteria, Indian J. Microbiol. , 2018, 58, 393-396. pubmed
  • C. Rens, F. Laval, R. Wattiez, P. Lefèvre, F. Dufrasne, M. Daffé and V. Fontaine, I3-Ag85 effect on phthiodiolone dimycocerosate synthesis, Tuberculosis, 2018, 108, 93-95. pubmed
  • J. Sjollema, S. A. J. Zaat, V. Fontaine, M. Ramstedt, R. Luginbuehl, K. Thevissen, J. Li, H. C. van der Mei and H. J. Busscher, In vitro methods for the evaluation of antimicrobial surface designs, Acta Biomater., 2018, 70, 12-24. pubmed
  • J. Soubhye, P. van Antwerpen and F. Dufrasne, Targeting cytosolic phospholipase A2α for novel anti-inflammatory agents, Curr. Med. Chem., 2018, 25, 2418-2447. pubmed
  • A. A. Vernekar, G. Berger, A. E. Czapar, F. A. Veliz, D. I. Wang, N. F. Steinmetz and S. J. Lippard, Speciation of phenanthriplatin and its analogs in the core of tobacco mosaic virus, J. Am. Chem. Soc. , 2018, 140, 4279-4287. pubmed
2017
  • G. Berger, I. Chab-Majdalani and S. Hanessian, Properties of the amide bond involving proline 4,5-methanologues: an experimental and theoretical study, Isr. J. Chem., 2017, 57, 292–302. doi
  • N. Blondiaux, M. Moune, M. Desroses, R. Frita, M. Flipo, V. Mathys, K. Soetaert, M. Kiass, V. Delorme, K. Djaout, V. Trebosc, C. Kemmer, R. Wintjens, A. Wohlkönig, R. Antoine, L. Huot, D. Hot, M. Coscolla, J. Feldmann, S. Gagneux, C. Locht, P. Brodin, M. Gitzinger, B. Déprez, N. Willand and A. R. Baulard, Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420, Science, 2017, 355, 1206-1211. pubmed
  • B. Chen, G. Berger and S. Hanessian, Metal coordination-controlled and bifunctional H-bonded catalysis in stereoselective intramolecular aldol cyclizations toward carbocyclic tertiary β-ketols,  European J. Org. Chem., 2017,  1, 2631-2636. doi
  • I. Chikh Alard, J. Soubhye, G. Berger, M. Gelbcke, S. Spassov, K. Amighi, J. Goole and F. Meyer, Triple-stimuli responsive polymers with fine tuneable magnetic response, Polym. Chem., 2017, 8, 2450-2456. doi
  • J. Ngezahayo, S. O. Ribeiro, V. Fontaine, L. Hari, C. Stévigny and P. Duez, In vitro study of five herbs used against microbial infections in Burundi, Phytother. Res., 2017,  31, 1571-1578. pubmed
  • J. Soubhye, I. Chikh Alard, I. Aldib, M. Prévost, M. Gelbcke, A. De Carvalho, P. G. Furtmüller, C. Obinger, J. Flemmig, S. Tadrent, F. Meyer, A. Rousseau, J. Nève, V. Mathieu, K. Zouaoui Boudjeltia, F. Dufrasne and P. Van Antwerpen, Discovery of novel potent reversible and irreversible myeloperoxidase inhibitors using virtual screening procedure, J. Med. Chem. , 2017, 60, 6563-6586. pubmed
  • P. Surriabre, G. Allende, M. Prado, L. Cáceres, D. Bellot, A. Torrico, K. Ustariz, S. Rojas, J. Barriga, P. Calle, L. Villarroel, R. M. Yañez, M. Baay, P. Rodriguez and V. Fontaine, Self-sampling for human papillomavirus DNA detection: a preliminary study of compliance and feasibility in BOLIVIA, BMC Womens Health , 2017, 17, 135. pubmed
  • A. Wohlkönig, H. Remaut, M. Moune, A. Tanina, F. Meyer, M. Desroses, J. Steyaert, N. Willand, A. Baulard and R. Wintjens, Structural analysis of the interaction between spiroisoxazoline SMARt-420 and the Mycobacterium tuberculosis repressor EthR2, Biochem. Biophys. Res. Commun. , 2017, 487, 403-408. pubmed
2016
  • I. Aldib, M. Gelbcke, J. Soubhye, M. Prévost, P. G. Furtmüller, C. Obinger, B. Elfving, I. C. Alard, G. Roos, C. Delporte, G. Berger, D. Dufour, K. Zouaoui Boudjeltia, J. Nève, F. Dufrasne and P. Van Antwerpen, Novel bis-arylalkylamines as myeloperoxidase inhibitors: design, synthesis, and structure-activity relationship study, Eur. J. Med. Chem. , 2016,123, 746-762. pubmed
  • G. Berger, K. Roeben, J. Soubhye, R. Wintjens and F. Meyer, Halogen bonding in multi-connected 1,2,2-triiodo-alkene involving geminal and/or vicinal iodines: a crystallographic and DFT study, CrystEngComm., 2016, 18, 683.
  • E. D. Bojilova, C. Weyn, M. H. Antoine and V. Fontaine, Extrachromosomal HPV-16 LCR transcriptional activation by HDACi opposed by cellular differentiation and DNA integration, Oncotarget, 2016, 7, 75526-7538. pubmed
  • A. K. Chattopadhyay, G. Berger and S. Hanessian, Strategies toward the total synthesis of calyciphylline B-type alkaloids: a computational perspective aided by DFT analysis, J. Org. Chem. , 2016, 81, 5074-5086. pubmed
  • A. K. Chattopadhyay, V. L. Ly, S. Jakkepally, G. Berger and S. Hannessian, Total synthesis of isodaphlongamine H: a possible biogenetic conundrum, Angew. Chemie Int. Ed, 2016,  55, 2577-2581. pubmed
  • V. Levet, R. Rosière, R. Merlos, L. Fusaro, G. Berger, K. Amighi and N. Wautoz, Development of controlled-release cisplatin dry powders for inhalation against lung cancers, Int. J. Pharm., 2016, 515, 209-220. pubmed
  • M. Y. Lim, G. LaMonte, M. C. S. Lee, C. Reimer, B. H. Tan, V. Corey, B. F. Tjahjadi, A. Chua, M. Nachon, R. Wintjens, P. Gedeck, B. Malleret, L. Renia, G. M. C. Bonamy, P. C. Ho, N. K. S. Yeung, E. D. Chow, L. Lim, D. A. Fidock, T. T. Diagana, E. A. Winzeler and P. Bifani, UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistance genes, Nat. Microbiol., 2016, 1, 16166. pubmed
  • M. Marloye, G. Berger, M. Gelbcke and F. Dufrasne F, A survey of the mechanisms of action of anticancer transition metal complexes, Future Med. Chem., 2016,  8, 2263-2286. pubmed
  • J. E. Mbosso Teinkela, J. C. Assob Nguedia, F. Meyer, E. Vouffo Donfack, B. Lenta Ndjakou, S. Ngouela, E. Tsamo, D. Adiogo, A. G. B. Azebaze and R. Wintjens, In vitro antimicrobial and anti-proliferative activities of plant extracts from Spathodea campanulata, Ficus bubu, and Carica papaya, Pharm. Biol. , 2016, 54, 1086-1095. pubmed
  • J. E. Mbosso Teinkela, X. Siwe Noundou, E. L. Nguemfo, F. Meyer, A. Djoukoue, P. Van Antwerpen, S. Ngouela, E. Tsamo, E. A. Mpondo, J. C. Vardamides, A. G. Azebaze and R. Wintjens, Identification of compounds with anti-proliferative activity from the wood of Ficus elastica Roxb. ex Hornem. aerial roots, Fitoterapia; 2016, 112, 65-73. pubmed
  • C. Rens, F. Laval, M. Daffé, O. Denis, R. Frita, A. Baulard, R. Wattiez, P. Lefèvre and V. Fontaine, Effects of lipid-lowering drugs on vancomycin susceptibility of mycobacteria, Antimicrob. Agents Chemother. , 2016, 60, 6193-6199. pubmed
  • J. Sá, J. Czapla-Masztafiak, E. Lipiec, Y. Kayser, D. L. Fernandes, J. Szlachetko, F. Dufrasne and G. Berger, Resonant X-ray emission spectroscopy of platinum(II) anticancer complexes, Analyst, 2016, 141, 1226-1232. pubmed
  • J. Soubhye, I. Aldib, C. Delporte, M. Prévost, F. Dufrasne and P. Van Antwerpen, Myeloperoxidase as a target for the treatment of inflammatory syndromes: mechanisms and structure activity relationships of inhibitors. Curr. Med. Chem. , 2016, 23, 3975-4008. pubmed
  • J. Soubhye, M. Gelbcke, P. Van Antwerpen, F. Dufrasne, M. Y. Boufadi, J. Nève, P. G. Furtmüller, C. Obinger, K. Zouaoui Boudjeltia and F. Meyer, From dynamic combinatorial chemistry to in vivo evaluation of reversible and irreversible myeloperoxidase inhibitors, ACS Med. Chem. Lett., 2016, 8, 206-210. pubmed
  • J. Soubhye, F. Meyer, P. Furtmüller, C. Obinger, F. Dufrasne and P. Van Antwerpen, Characterization of chemical features of potent myeloperoxidase inhibitors, Future Med. Chem., 2016, 8, 1163-1177. pubmed
  • R. Wintjens, D. Bozon, K. Belabbas, F. MBou, J. P. Girardet, P. Tounian, M. Jolly, F. Boccara, A. Cohen, A. Karsenty, B. Dubern, J. C. Carel, A. Azar-Kolakez, F. Feillet, F. Labarthe, A. M. Gorsky, A. Horovitz, C. Tamarindi, P. Kieffer, A. Lienhardt, O. Lascols, M. Di Filippo and F. Dufernez, Global molecular analysis and APOE mutations in a cohort of autosomal dominant hypercholesterolemia patients in Francen J. Lipid Res., 2016, 57, 482-491. pubmed
  • H. Zater, J. Huet, V. Fontaine, S. Benayache, C. Stévigny, P. Duez and F. Benayache, Chemical constituents, cytotoxic, antifungal and antimicrobial properties of Centaurea diluta Ait. subsp. algeriensis (Coss. & Dur.) Maire. Asian Pac. J. Trop. Med. , 2016, 9, 554-561. pubmed
2015
  • G. Berger, L. Fusaro, M. Luhmer, J. Czapla-Masztafiak, E. Lipiec, J. Szlachetko, Y. Kayser, D. L. Fernandes, J. Sá, F. Dufrasne and S. Bombard, Insights into the structure-activity relationships of chiral 1,2-diaminophenylalkane platinum(II) anticancer derivatives, J. Biol. Inorg. Chem., 2015, 20, 841-853. pubmed
  • M. Boeckstaens, A. Merhi, E. Llinares, P. Van Vooren, J. Y. Springael, R. Wintjens and A. M.  Marini, Identification of a novel regulatory mechanism of nutrient transport controlled by TORC1-Npr1-Amu1/Par32, PLoS Genet. , 2015, 11, e1005382. pubmed
  • F. Dufrasne, Technologies to develop new metal medicines, Drug Discov. Today Technol., 2015, 16, 31-32. pubmed
  • E. Dupré, J. Herrou, M. F. Lensink, R. Wintjens, A. Vagin, A. Lebedev, S. Crosson, V. Villeret, C. Locht, R. Antoine and F. Jacob-Dubuisson, Virulence regulation with Venus flytrap domains: structure and function of the periplasmic moiety of the sensor-kinase BvgS, PLoS Pathog., 2015, 11, e1004700. pubmed
  • H. L. Haver, A. Chua, P. Ghode, S. B. Lakshminarayana, A. Singhal, B. Mathema, R. Wintjens and P. Bifani, Mutations in genes for the F420 biosynthetic pathway and a nitroreductase enzyme are the primary resistance determinants in spontaneous in vitro-selected PA-824-resistant mutants of Mycobacterium tuberculosis, Antimicrob. Agents Chemother., 2015, 59, 5316-5323. pubmed
  • E. Mbosso, L. Kamdem, J. C. A. Nguedia, F. Meyer, D. Ebelle, B. N. Lenta, J. Tchouankeu, E. Tsamo, Y. Looze, D. D. D. Adiogo, G. A. B. Azebaze and R. Wintjens, In vitro evaluation of antimicrobial and antiproliferative activities for compounds isolated from the Ficus bubu Warb. (Moraceae) fruits: chemotaxonomic significance, Drug delivery letters, 2015, 5, 122-131.
  • J. Sá, J. Czapla-Masztafiak, E. Lipiec, Y. Kayser, W. Kwiatek, B. Wood, G. B. Deacon, G. Berger, F. Dufrasne, D. L. Fernandes and J. Szlachetko, The use of Resonant X-ray Emission Spectroscopy (RXES) for the electronic analysis of metal complexes and their interactions with biomolecules. Drug Discov. Today Technol., 2015, 16, 1-6. pubmed
  • K. Soetaert, C. Rens, X. M. Wang, J. De Bruyn, M. A. Lanéelle, F. Laval, A. Lemassu, M. Daffé, P. Bifani, V. Fontaine and P.  Lefèvre, Increased vancomycin susceptibility in mycobacteria: a new approach to identify synergistic activity against multidrug-resistant mycobacteria. Antimicrob. Agents Chemother., 2015, 59, 5057-5060. pubmed
  • J. Soubhye, I. C. Alard, P. van Antwerpen and F. Dufrasne, Type 2 17-β hydroxysteroid dehydrogenase as a novel target for the treatment of osteoporosis. Future Med. Chem., 2015, 7, 1431-1456. pubmed
  • X. M. Wang, K. Soetaert, P. Peirs, M. Kalai, V. Fontaine, J. P. Dehaye and P. Lefèvre, Biochemical analysis of the NAD+-dependent malate dehydrogenase, a substrate of several serine/threonine protein kinases of Mycobacterium tuberculosis. PLoS One, 2015, 10, e0123327. pubmed
Mis à jour le 1 février 2023