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Cédric Delporte
Research in Drug Development (RD3)
Pharmacognosy Bioanalysis and Drug Discovery
ContactResearch activities
His research field is the analysis of posttranslational modifications (PTMs) of proteins by mass spectrometry. The targeted PTMs are the oxidative ones (oxidation of tryptophan, tyrosine, lysine, cysteine, …) in the context of chronic inflammation pathologies/oxidative stress like in atherosclerosis/cardiovascular disease. Another type of PTMs that he studies, is the glycosylation. Glycosylation is the most abundant modification of proteins, and in the context of therapeutic proteins, more than 60 % of the currently approved biotherapeutics are glycosylated. His research is also devoted to the development of analytical tools for the other “omics” fields mainly metabolomics and proteomics. He currently develops his research projects in the RD3-PBM unit and the Analytical Platform of the Faculty of Pharmacy
Top ten recent articles
FTIR spectroscopy as an analytical tool to compare glycosylation in therapeutic monoclonal antibodies
Derenne, A., Derfoufi, K.-M., Cowper, B., Delporte, C., & Goormaghtigh, E. (2020). FTIR spectroscopy as an analytical tool to compare glycosylation in therapeutic monoclonal antibodies. Analytica chimica acta, 1112, 62-71. doi:10.1016/j.aca.2020.03.038
The other myeloperoxidase: Emerging functions
Vanhamme, L., Zouaoui Boudjeltia, K., Van Antwerpen, P., & Delporte, C. (2018). The other myeloperoxidase: Emerging functions. Archives of biochemistry and biophysics, 649, 1-14. doi:10.1016/j.abb.2018.03.037
Native and myeloperoxidase-oxidized low-density lipoproteins act in synergy to induce release of resolvin-D1 from endothelial cells.
Dufour, D., Khalil, A., Nuyens, V., Rousseau, A., Delporte, C., Noyon, C., Cortese, M., Reye, F., Pireaux, V., Neve, J., Vanhamme, L., Robaye, B., Lelubre, C., Desmet, J.-M., Raes, M., Zouaoui Boudjeltia, K., & Van Antwerpen, P. (2018). Native and myeloperoxidase-oxidized low-density lipoproteins act in synergy to induce release of resolvin-D1 from endothelial cells. Atherosclerosis, 272, 108-117. doi:10.1016/j.atherosclerosis.2018.03.012
Metabolomics fingerprint of coffee species determined by untargeted-profiling study using LC-HRMS
Souard, F., Delporte, C., Stoffelen, P., Thévenot, E. E., Noret, N., Dauvergne, B., Kauffmann, J.-M., Van Antwerpen, P., & Stevigny, C. (2018). Metabolomics fingerprint of coffee species determined by untargeted-profiling study using LC-HRMS. Food chemistry, 245, 603-612. doi:10.1016/j.foodchem.2017.10.022
Batch-to-batch N-glycosylation Study of Infliximab, Trastuzumab, and Bevacizumab, and Stability Study of Bevacizumab
Planinc, A., Dejaegher, B., Vander Heyden, Y., Viaene, J., Van Praet, S., Rappez, F., Van Antwerpen, P., & Delporte, C. (2017). Batch-to-batch N-glycosylation Study of Infliximab, Trastuzumab, and Bevacizumab, and Stability Study of Bevacizumab. European journal of hospital pharmacy, 24(5), 286-292. doi:10.1136/ejhpharm-2016-001022
LC-MS analysis combined with principal component analysis and soft independent modelling by class analogy for a better detection of changes in N-glycosylation profiles of therapeutic glycoproteins.
Planinc, A., Dejaegher, B., Vander Heyden, Y., Viaene, J., Van Praet, S., Rappez, F., Van Antwerpen, P., & Delporte, C. (2017). LC-MS analysis combined with principal component analysis and soft independent modelling by class analogy for a better detection of changes in N-glycosylation profiles of therapeutic glycoproteins. Analytical and Bioanalytical Chemistry. doi:10.1007/s00216-016-9683-9
Glycan characterization of biopharmaceuticals: Updates and perspectives.
Planinc, A., Bones, J., Dejaegher, B., Van Antwerpen, P., & Delporte, C. (2016). Glycan characterization of biopharmaceuticals: Updates and perspectives. Analytica chimica acta, 921, 13-27. doi:10.1016/j.aca.2016.03.049
Allosteric regulation of G protein-coupled receptor activity by phospholipids.
Dawaliby, R., Trubbia, C., Delporte, C., Masureel, M., Van Antwerpen, P., Kobilka, B. K., & Govaerts, C. (2016). Allosteric regulation of G protein-coupled receptor activity by phospholipids. Nature Chemical Biology, 12(1), 1960, 35-39. doi:10.1038/nchembio.1960
Comparative analysis of monoclonal antibody N-glycosylation using stable isotope labelling and UPLC-fluorescence-MS
Millán Martín, S., Delporte, C., Farrell, A., McLoughlin, N., Bones, J., & Navas Iglesias, N. (2015). Comparative analysis of monoclonal antibody N-glycosylation using stable isotope labelling and UPLC-fluorescence-MS. Analyst, 140(5), 1442-1447. doi:10.1039/c4an02345e
Multidomain Human Peroxidasin 1 is a Highly Glycosylated and Stable Homotrimeric High-Spin Ferric Peroxidase.
Soudi, M., Paumann-Page, M., Delporte, C., Pirker, K. K., Bellei, M., Edenhofer, E., Stadlmayr, G., Battistuzzi, G., Zouaoui Boudjeltia, K., Furtmüller, P. G., Van Antwerpen, P., & Obinger, C. (2015). Multidomain Human Peroxidasin 1 is a Highly Glycosylated and Stable Homotrimeric High-Spin Ferric Peroxidase. The Journal of biological chemistry. doi:10.1074/jbc.M114.632273
Career
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Since 2017: Associate Professor at the Faculty of Pharmacy, RD3-PBM
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2013-2017: Postdoctoral fellow on FNRS grant in the Laboratory of Pharmaceutical Chemistry and Analytical Platform of the Faculty of Pharmacy (ULB, Belgium)
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2012-2013: Postdoctoral fellow at NIBRT (National Institute for Bioprocessing Research and Training, Dublin, Ireland) in the group of Prof. P. RUDD (2012-2013)
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2012: PhD in Pharmaceutical sciences "Study by a liquid chromatography/mass spectrometry system of the modifications of apolipolipoprotein B-100 induced by myeloperoxidase.", Faculty of Pharmacy (ULB, Belgium)
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2008-2012: Research fellow of the FNRS (Belgium) and PhD student in the Laboratory of Pharmaceutical Chemistry (ULB, Belgium)
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2012: Pharmacist with “La Plus Grande Distinction” at the Faculty of Pharmacy, ULB, Belgium)