Pharmacognosy, Bioanalysis and Drug Discovey (PBDD)

The Unit Pharmacognosy, Bioanalysis & Drug Discovery (PBDD) is one of the research units of the Faculty of Pharmacy. Specialized in the study of organic drugs, from plants or biotherapeutics, the PBDD Unit promotes researches in the domain of the development and the analysis of molecules with therapeutical potential. For bioguided fractionation of medicinal plant extracts, analysis and quality control of drugs, biotherapeutic characterization, biomarker research for validation of therapeutical targets, PBDD Unit proposes performant analytical tools such as liquid/gas chromatography, spectroscopic methods (UV-Vis, NIR, Fluorimetry), electrochemistry detectors and mass spectrometry. PBDD Unit is also responsible for the Analytical Platform of the Faculty of Pharmacy. 

Academic members

Senior Academic members

Postodoctoral fellows

PhD students

Administrative, technical, management and / or specialized members : 

Alumni

2021

Duchateau, C., Canfyn, M., Desmedt, B., Kauffmann, J.-M., Stévigny, C., De Braekeleer, K., Deconinck, E. CBD oils on the Belgian market: A validated MRM GC-MS/MS method for routine quality control using QuEChERS sample clean up (2021) Journal of pharmaceutical and biomedical analysis, 205, p. 114344. Abstract

Rojo-Poveda, O., Zeppa, G., Ferrocino, I., Stévigny, C., Barbosa-Pereira, L. Chemometric classification of cocoa bean shells based on their polyphenolic profile determined by rp-hplc-pda analysis and spectrophotometric assays (2021) Antioxidants, 10 (10), art. no. 1533, . Abstract

Deconinck, E., Aït-Kaci, C., Raes, A., Canfyn, M., Bothy, J.-L., Duchateau, C., Mees, C., De Braekeleer, K., Gremaux, L., Blanckaert, P. An infrared spectroscopic approach to characterise white powders, easily applicable in the context of drug checking, drug prevention and on-site analysis (2021) Drug Testing and Analysis, 13 (3), pp. 679-693. Abstract

Forceville, X., Van Antwerpen, P., Preiser, J.-C. Selenocompounds and Sepsis: Redox Bypass Hypothesis for Early Diagnosis and Treatment: Part A - Early Acute Phase of Sepsis: An Extraordinary Redox Situation (Leukocyte/Endothelium Interaction Leading to Endothelial Damage) (2021) Antioxidants and Redox Signaling, 35 (2), pp. 113-138. Abstract

Colin, M., Dechêne, L., Ceusters, J., Niesten, A., Demazy, C., Lagneaux, L., Zouaoui Boudjeltia, K., Franck, T., Van Antwerpen, P., Renard, P., Mathieu, V., Serteyn, D. Priming of mesenchymal stem cells with a hydrosoluble form of curcumin allows keeping their mesenchymal properties for cell-based therapy development (2021) Journal of Cellular and Molecular Medicine, 25 (10), pp. 4877-4881. Abstract

Boufadi, M.Y., Soubhye, J., Van Antwerpen, P. Anti-inflammatory, antioxidant effects, and bioaccessibility of Tigzirt propolis (2021) Journal of Food Biochemistry, 45 (4), art. no. e13663, . Abstract

Ribeiro, S.O., Fraselle, S., Baudoux, D., Zhiri, A., Stévigny, C., Souard, F. Proposals for Antimicrobial Testing Guidelines Applied on Ajowan and Spanish Lavender Essential Oils (2021) Planta Medica, 87 (10-11), pp. 754-763. Abstract

Ribeiro, S.O., Fontaine, V., Mathieu, V., Abdesselam, Z., Dominique, B., Stevigny, C., Souard, F. Antibacterial activities of homemade matrices miming essential oils compared to commercial ones (2021) Antibiotics, 10 (5), art. no. 584. Abstract

Vanhaverbeke, C., Touboul, D., Elie, N., Prévost, M., Meunier, C., Michelland, S., Cunin, V., Ma, L., Vermijlen, D., Delporte, C., Pochet, S., Le Gouellec, A., Sève, M., Van Antwerpen, P., Souard, F. Untargeted metabolomics approach to discriminate mistletoe commercial products (2021) Scientific Reports, 11 (1), 14205. Abstract

De Becker, B., Hupkens, E., Dewachter, L., Coremans, C., Delporte, C., Van Antwerpen, P., Franck, T., Zouaoui Boudjeltia, K., Cullus, P., van de Borne, P. Acute effects of hypouricemia on endothelium, oxidative stress, and arterial stiffness: A randomized, double-blind, crossover study (2021) Physiological Reports, 9 (17), e15018 Abstract

Coremans, C., Delporte, C., Cotton, F., Van De Borne, P., Boudjeltia, K.Z., Van Antwerpen, P. Mass spectrometry for the monitoring of lipoprotein oxidations by myeloperoxidase in cardiovascular diseases (2021) Molecules, 26 (17), 5227 Abstract

Sakira, A.K., Mees, C., De Braekeleer, K., Delporte, C., Yameogo, J., Yabre, M., Some, T.I., Van Antwerpen, P., Mertens, D., Kauffmann, J.M. Determination of the quality of metronidazole formulations by near-infrared spectrophotometric analysis (2021) Talanta Open, 3, Abstract

Rojo-Poveda, O., Ribeiro, S.O., Anton-Sales, C., Keymeulen, F., Barbosa-Pereira, L., Delporte, C., Zeppa, G., Stévigny, C. Evaluation of Cocoa Bean Shell Antimicrobial Activity: A Tentative Assay Using a Metabolomic Approach for Active Compound Identification (2021) Planta Medica, 87 (10-11), art. no. E1330, pp. 841-849. Abstract

Acheampong, A., Mélot, C., Benjelloun, M., Cheval, M., Reye, F., Delporte, C., van Antwerpen, P., Franck, T., Mc Entee, K., van de Borne, P. Effects of hyperoxia and cardiovascular risk factors on myocardial ischaemia–reperfusion injury: a randomized, sham-controlled parallel study (2021) Experimental Physiology, 106 (5), pp. 1249-1262. Abstract

Delporte, C., Noret, N., Vanhaverbeke, C., Hardy, O.J., Martin, J.-F., Tremblay-Franco, M., Touboul, D., Gorel, A., Faes, M., Stévigny, C., Van Antwerpen, P., Souard, F. Does the phytochemical diversity of wild plants like the erythrophleum genus correlate with geographical origin? (2021) Molecules, 26 (6). Abstract

Montis, A., Souard, F., Delporte, C., Stoffelen, P., Stévigny, C., Van Antwerpen, P. Coffee Leaves: An Upcoming Novel Food? (2021) Planta Medica, 87 (12-13), pp. 949-963. Abstract

Helali, Y., Sharma, S., Vandeput, M., Welba, D., Van Antwerpen, P., Marchant, A., Delporte, C. Fc Glycosylation Characterization of Human Immunoglobulins G Using Immunocapture and LC-MS (2021) Methods in Molecular Biology, 2271, pp. 57-71. Abstract

Derenne, A., Derfoufi, K.-M., Cowper, B., Delporte, C., Butré, C.I., Goormaghtigh, E. Analysis of Glycoproteins by ATR-FTIR Spectroscopy: Comparative Assessment (2021) Methods in Molecular Biology, 2271, pp. 361-374. Abstract

Pireaux, V., Delporte, C., Rousseau, A., Desmet, J.-M., Van Antwerpen, P., Raes, M., Zouaoui Boudjeltia, K. M2 monocyte polarization in dialyzed patients is associated with increased levels of M-CSF and myeloperoxidase-associated oxidative stress: Preliminary results (2021) Biomedicines, 9 (1). Abstract

2020

Duchateau, C., Kauffmann, J.-M., Canfyn, M., Stévigny, C., De Braekeleer, K., Deconinck, E.
Discrimination of legal and illegal Cannabis spp. according to European legislation using near infrared spectroscopy and chemometrics (2020) Drug Testing and Analysis, 12 (9), pp. 1309-1319. Abstract

Ma, L., Phalke, S., Stévigny, C., Souard, F., Vermijlen, D. Mistletoe-Extract Drugs Stimulate Anti-Cancer Vγ9Vδ2 T Cells (2020) Cells, 9 (6), . Abstract

Soubhye, J., Van Antwerpen, P., Dufrasne, F. A patent review of myeloperoxidase inhibitors for treating chronic inflammatory syndromes (focus on cardiovascular diseases, 2013-2019) (2020) Expert Opinion on Therapeutic Patents, 30 (8), pp. 595-608. Abstract

Tie, Y., Duchateau, C., Van de Steene, S., Mees, C., De Braekeleer, K., De Beer, T., Adams, E., Deconinck, E. Spectroscopic techniques combined with chemometrics for fast on-site characterization of suspected illegal antimicrobials (2020) Talanta, 217, art. no. 121026, . Abstract

Rojo-Poveda, O., Barbosa-Pereira, L., Orden, D., Stévigny, C., Zeppa, G., Bertolino, M. Physical properties and consumer evaluation of cocoa bean shell-functionalized biscuits adapted for diabetic consumers by the replacement of sucrose with tagatose (2020) Foods, 9 (6), art. no. 814. Abstract

Rojo-Poveda, O., Barbosa-Pereira, L., Zeppa, G., Stévigny, C. Cocoa bean shell—a by-product with nutritional properties and biofunctional potential (2020) Nutrients, 12 (4), art. no. 1123, . Abstract

Manya, M.H., Keymeulen, F., Ngezahayo, J., Bakari, A.S., Kalonda, M.E., Kahumba, B.J., Duez, P., Stévigny, C., Lumbu, S.J.-B. Antimalarial herbal remedies of Bukavu and Uvira areas in DR Congo: An ethnobotanical survey (2020) Journal of Ethnopharmacology, 249, art. no. 112422, . Abstract

Rojo-Poveda, O., Barbosa-Pereira, L., Khattabi, C.E., Youl, E.N.H., Bertolino, M., Delporte, C., Pochet, S., Stévigny, C. Polyphenolic and methylxanthine bioaccessibility of cocoa bean shell functional biscuits: Metabolomics approach and intestinal permeability through CaCo-2 cell models (2020) Antioxidants, 9 (11). Abstract

Derenne, A., Derfoufi, K.-M., Cowper, B., Delporte, C., Goormaghtigh, E.
FTIR spectroscopy as an analytical tool to compare glycosylation in therapeutic monoclonal antibodies
(2020) Analytica Chimica Acta, 1112, pp. 62-71. Abstract

Carvalho A, Viaene J, Vandenbussche G, De Braekeleer K, Masereel B, Wouters J, Souard F, Vander Heyden Y, Van Antwerpen P, Delporte C, Mathieu V. A new potential anti-cancer beta-carboline derivative decreases the expression levels of key proteins involved in glioma aggressiveness: A proteomic investigation. (2020) Drug Dev Res. 81 (1), pp. 32-42. Abstract

2019

Christian G, Kauffmann JM. Editorial on 60(th) Anniversary of Talanta. Talanta. 2019 Nov 1;204:883. Abstract

Franck T, Aldib I, Zouaoui Boudjeltia K, Furtmüller PG, Obinger C, Neven P, Prévost M, Soubhye J, Van Antwerpen P, Mouithys-Mickalad A, Serteyn D. The soluble curcumin derivative NDS27 inhibits superoxide anion production by neutrophils and acts as substrate and reversible inhibitor of myeloperoxidase. Chem Biol Interact. 2019 Jan 5;297:34-43. Abstract

Cortese M, Delporte C, Dufour D, Noyon C, Chaumont M, De Becker B, Reye F, Rousseau A, Eker OF, Nève J, Piagnerelli M, Boudjeltia KZ, Robaye B, Van Antwerpen P. Validation of a LC/MSMS method for simultaneous quantification of 9 nucleotides in biological matrices. Talanta. 2019 Feb 1;193:206-214. Abstract

Medfai H, Khalil A, Rousseau A, Nuyens V, Paumann-Page M, Sevcnikar B, Furtmüller PG, Obinger C, Moguilevsky N, Peulen O, Herfs M, Castronovo V, Amri M, Van Antwerpen P, Vanhamme L, Zouaoui Boudjeltia K. Human peroxidasin 1 promotes angiogenesis through ERK1/2, Akt, and FAK pathways. Cardiovasc Res. 2019 Feb 1;115(2):463-475. Abstract

Zeng S, Soetaert K, Ravon F, Vandeput M, Bald D, Kauffmann JM, Mathys V, Wattiez R, Fontaine V. Isoniazid Bactericidal Activity Involves Electron Transport Chain Perturbation. Antimicrob Agents Chemother. 2019 Feb 26;63(3). Abstract

Colin M, Delporte C, Janky R, Lechon AS, Renard G, Van Antwerpen P, Maltese WA, Mathieu V. Dysregulation of Macropinocytosis Processes in Glioblastomas May Be Exploited to Increase Intracellular Anti-Cancer Drug Levels: The Example of Temozolomide. Cancers (Basel). 2019 Mar 22;11(3). Abstract

Rojo-Poveda O, Barbosa-Pereira L, Mateus-Reguengo L, Bertolino M, Stévigny C, Zeppa AG. Effects of Particle Size and Extraction Methods on Cocoa Bean Shell Functional Beverage. Nutrients. 2019 Apr 17;11(4). Abstract

2018

Tomani JCD, Gainkam LOT, Nshutiyayesu S, Mukazayire MJ, Ribeiro SO, Stevigny C, Frederich M, Muganga R, Souopgui J. An ethnobotanical survey and inhibitory effects on NLRP3 inflammasomes/Caspase-1 of herbal recipes' extracts traditionally used in Rwanda for asthma treatment. J Ethnopharmacol. 2018 Dec 5;227:29-40.

Khalil A, Poelvoorde P, Fayyad-Kazan M, Rousseau A, Nuyens V, Uzureau S, Biston P, El-Makhour Y, Badran B, Van Antwerpen P, Boudjeltia KZ, Vanhamme L. Apoliporotein L3 interferes with endothelial tube formation via regulation of ERK1/2, FAK and Akt signaling pathway. Atherosclerosis. 2018 Dec;279:73-87.

Rodríguez-Gómez R, Vanheuverzwjin J, Souard F, Delporte C, Stevigny C, Stoffelen P, De Braekeleer K, Kauffmann JM. Determination of Three Main Chlorogenic Acids in Water Extracts of Coffee Leaves by Liquid Chromatography Coupled to an Electrochemical Detector. Antioxidants (Basel). 2018 Oct 15;7(10).

Khalil A, Medfai H, Poelvoorde P, Kazan MF, Delporte C, Van Antwerpen P, El-Makhour Y, Biston P, Delrée P, Badran B, Vanhamme L, Boudjeltia KZ. Myeloperoxidase promotes tube formation, triggers ERK1/2 and Akt pathways and is expressed endogenously in endothelial cells. Arch Biochem Biophys. 2018 Sep 15;654:55-69.

Kajouj S, Marcelis L, Mattiuzzi A, Grassin A, Dufour D, Van Antwerpen P, Boturyn D, Defrancq E, Surin M, De Winter J, Gerbaux P, Jabin I, Moucheron C. Synthesis and photophysical studies of a multivalent photoreactive Ru(II)-calix[4]arene complex bearing RGD-containing cyclopentapeptides. Beilstein J Org Chem. 2018 Jul 16;14:1758-1768. doi: 10.3762/bjoc.14.150. eCollection 2018.

Chaumont M, de Becker B, Zaher W, Culié A, Deprez G, Mélot C, Reyé F, Van Antwerpen P, Delporte C, Debbas N, Boudjeltia KZ, van de Borne P. Differential Effects of E-Cigarette on Microvascular Endothelial Function, Arterial Stiffness and Oxidative Stress: A Randomized Crossover Trial. Sci Rep. 2018 Jul 10;8(1):10378.

Chaumont M, Bernard A, Pochet S, Mélot C, El Khattabi C, Reye F, Boudjeltia KZ, Van Antwerpen P, Delporte C, van de Borne P. High-Wattage E-Cigarettes Induce Tissue Hypoxia and Lower Airway Injury: A Randomized Clinical Trial. Am J Respir Crit Care Med. 2018 Jul 1;198(1):123-126.

Vanhamme L, Zouaoui Boudjeltia K, Van Antwerpen P, Delporte C. The other myeloperoxidase: Emerging functions. Arch Biochem Biophys. 2018 Jul 1;649:1-14.

Dufour D, Khalil A, Nuyens V, Rousseau A, Delporte C, Noyon C, Cortese M, Reyé F, Pireaux V, Nève J, Vanhamme L, Robaye B, Lelubre C, Desmet JM, Raes M, Boudjeltia KZ, Van Antwerpen P. Native and myeloperoxidase-oxidized low-density lipoproteins act in synergy to induce release of resolvin-D1 from endothelial cells. Atherosclerosis. 2018 May;272:108-117.

Delporte C, Zouaoui Boudjeltia K, Furtmüller PG, Maki RA, Dieu M, Noyon C, Soudi M, Dufour D, Coremans C, Nuyens V, Reye F, Rousseau A, Raes M, Moguilevsky  N, Vanhaeverbeek M, Ducobu J, Nève J, Robaye B, Vanhamme L, Reynolds WF, Obinger C, Van Antwerpen P. Myeloperoxidase-catalyzed oxidation of cyanide to cyanate: A potential carbamylation route involved in the formation of atherosclerotic plaques? J Biol Chem. 2018 Apr 27;293(17):6374-6386.

Souard F, Delporte C, Stoffelen P, Thévenot EA, Noret N, Dauvergne B, Kauffmann JM, Van Antwerpen P, Stévigny C. Metabolomics fingerprint of coffee species determined by untargeted-profiling study using LC-HRMS. Food Chem. 2018 Apr 15;245:603-612.

Dufour D, Khalil A, Nuyens V, Rousseau A, Delporte C, Noyon C, Cortese M, Reyé F, Pireaux V, Nève J, Vanhamme L, Robaye B, Lelubre C, Desmet JM, Raes M, Boudjeltia KZ, Van Antwerpen P. Data on myeloperoxidase-oxidized low-density lipoproteins stimulation of cells to induce release of resolvin-D1. Data Brief. 2018 Apr 4;18:1160-1171. doi: 10.1016/j.dib.2018.03.131. eCollection 2018 Jun.

Rosière R, Van Woensel M, Gelbcke M, Mathieu V, Hecq J, Mathivet T, Vermeersch M, Van Antwerpen P, Amighi K, Wauthoz N. New Folate-Grafted Chitosan Derivative To Improve Delivery of Paclitaxel-Loaded Solid Lipid Nanoparticles for Lung Tumor Therapy by Inhalation. Mol Pharm. 2018 Mar 5;15(3):899-910.

Mees C, Souard F, Delporte C, Deconinck E, Stoffelen P, Stévigny C, Kauffmann JM, De Braekeleer K. Identification of coffee leaves using FT-NIR spectroscopy and SIMCA. Talanta. 2018 Jan 15;177:4-11. doi: 10.1016/j.talanta.2017.09.056.

Rodríguez-Gómez R, Vandeput M, Zafra-Gómez A, Kauffmann JM. Liquid chromatography-electrochemical detection for the determination of ethoxyquin and its dimer in pear skin and salmon samples. Talanta. 2018 Jan 15;177:157-162.

Soubhye J, Van Antwerpen P, Dufrasne F. Targeting Cytosolic Phospholipase A2α for Novel Anti-Inflammatory Agents. Curr Med Chem. 2018;25(21):2418-2447.

Kauffmann JM, Bakirhan NK, Bozal-Palabiyik B, Uslu B, Rodriguez Gomez R, Vandeput M, Ozkan SA. Electrochemical Detectors in Liquid Chromatography: Recent Trends in Pharmaceutical and Biomedical Analysis. Curr Med Chem. 2018;25(33):4050-4065.

2017

Roumeguère T, Van Antwerpen P, Fathi H, Rousseau A, Vanhamme L, Franck T, Costa C, Morelli A, Lelubre C, Hauzeur C, Raes M, Serteyn D, Wespes E, Vanhaeverbeek M, Zouaoui Boudjeltia K. Relationship between oxidative stress and erectile function. Free Radic Res. 2017 Dec;51(11-12):924-931.

Roumeguère T, Sfeir J, El Rassy E, Albisinni S, Van Antwerpen P, Boudjeltia KZ, Farès N, Kattan J, Aoun F. Oxidative stress and prostatic diseases. Mol Clin Oncol. 2017 Nov;7(5):723-728.

Ngezahayo J, Ribeiro SO, Fontaine V, Hari L, Stévigny C, Duez P. In vitro Study of Five Herbs Used Against Microbial Infections in Burundi. Phytother Res. 2017 Oct;31(10):1571-1578.

Cheraft-Bahloul N, Husson C, Ourtioualous M, Sinaeve S, Atmani D, Stévigny C, Nortier JL, Antoine MH. Protective Effects of Pistacia lentiscus L. fruit extract against calcium oxalate monohydrate induced proximal tubular injury. J Ethnopharmacol. 2017 Sep 14;209:248-254.

Planinc A, Dejaegher B, Vander Heyden Y, Viaene J, Van Praet S, Rappez F, Van Antwerpen P, Delporte C. Batch-to-batch N-glycosylation study of infliximab, trastuzumab and bevacizumab, and stability study of bevacizumab. Eur J Hosp Pharm. 2017 Sep;24(5):286-292.

Soubhye J, Chikh Alard I, Aldib I, Prévost M, Gelbcke M, De Carvalho A, Furtmüller PG, Obinger C, Flemmig J, Tadrent S, Meyer F, Rousseau A, Nève J, Mathieu V, Zouaoui Boudjeltia K, Dufrasne F, Van Antwerpen P. Discovery of Novel Potent Reversible and Irreversible Myeloperoxidase Inhibitors Using Virtual Screening Procedure. J Med Chem. 2017 Aug 10;60(15):6563-6586.

Rasamiravaka T, Ngezahayo J, Pottier L, Ribeiro SO, Souard F, Hari L, Stévigny C, Jaziri ME, Duez P. Terpenoids from Platostoma rotundifolium (Briq.) A. J. Paton Alter the Expression of Quorum Sensing-Related Virulence Factors and the Formation of Biofilm in Pseudomonas aeruginosa PAO1. Int J Mol Sci. 2017 Jun 14;18(6). pii: E1270.

Gau J, Prévost M, Van Antwerpen P, Sarosi MB, Rodewald S, Arnhold J, Flemmig J. Tannins and Tannin-Related Derivatives Enhance the (Pseudo-)Halogenating Activity of Lactoperoxidase. J Nat Prod. 2017 May 26;80(5):1328-1338.

Noyon C, Roumeguère T, Delporte C, Dufour D, Cortese M, Desmet JM, Lelubre C, Rousseau A, Poelvoorde P, Nève J, Vanhamme L, Boudjeltia KZ, Van Antwerpen P. The presence of modified nucleosides in extracellular fluids leads to the specific incorporation of 5-chlorocytidine into RNA and modulates the transcription and translation. Mol Cell Biochem. 2017 May;429(1-2):59-71.

Chopard B, de Sousa DR, Lätt J, Mountrakis L, Dubois F, Yourassowsky C, Van Antwerpen P, Eker O, Vanhamme L, Perez-Morga D, Courbebaisse G, Lorenz E, Hoekstra AG, Boudjeltia KZ. A physical description of the adhesion and aggregation of platelets. R Soc Open Sci. 2017 Apr 12;4(4):170219.

Planinc A, Dejaegher B, Heyden YV, Viaene J, Van Praet S, Rappez F, Van Antwerpen P, Delporte C. LC-MS analysis combined with principal component analysis and soft independent modelling by class analogy for a better detection of changes in N-glycosylation profiles of therapeutic glycoproteins. Anal Bioanal Chem. 2017 Jan;409(2):477-485.

National

• S. Bousbata, ULB, Faculty of Sciences, IBMM
• E. Cogan, ULB, Faculty of Medicine, Internal Medicine, CHU Erasme
• F. Corraza, LHUB, CHU Brugmann
• P. Durez, UCL, Rhumatology Department, CHU Saint-Luc
• E. Goormaghtigh, ULB, Faculty of Sciences, SFMB Laboratory
• C. Govaerts, ULB, Faculty of Sciences, SFMB Laboratory
• P. Jacobs, PharmaFluidics, Ghent
• D. Mangelings, VUB, Department of Analytical Chemistry and Pharmaceutical Technology, FABI
• A. Marchant, ULB, IMI
• J. Nortier, ULB, Faculty of Medicine, Nephrology Laboratory
• A. Nzeusseu Toukap, UCL, Rhumatology Department, CHU Saint-Luc
• M. Piagnerelli, ULB, Experimental Medicine Laboratory of CHU Vésale
• M. Raes, UNamur, Namur Research Institute for Life Sciences (Narilis)
• T. Roumeguère, ULB, Faculty of Medicine, Urology Department, CHU Erasme
• J.-M. Ruysschaert, ULB, Faculty of Sciences, SFMB Laboratory
• P. Vanden Borne, ULB, Faculty of Medicine, Internal Medicine, CHU Erasme
• Y. Vander Heyden, VUB, Department of Analytical Chemistry and Pharmaceutical Technology, FABI
• A. Van Eeckhaut, VUB, Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neurosciences (C4N)
• L. Vanhamme, ULB, Faculty of Sciences, IBMM
• N. Verbruggen, ULB, Faculty of Sciencses, LPGMP
• K. Zouaoui Boudjeltia, ULB, Experimental Medicine Laboratory of CHU Vésale

Europe

• J. Bones, National Institute of Bioprocessing Research and Training, NIBRT, Ireland
• F. Foulquier, Univesité de Lille 1, UGSF, Villeneuve d’Ascq, France
• E. Malle, Medical University of Graz, Austria
• S. Millan-Martin, National Institute of Bioprocessing Research and Training, NIBRT, Ireland
• W. Morelle, Univesité de Lille 1, UGSF, Villeneuve d’Ascq, France
• C. Obinger, Department of Chemistry, Division of Biochemistry, BOKU, University of Natural Resources and Applied Sciences, Vienna, Austria
• E. Thevenot, CEA Saclay, Laboratory for Data Analysis and Systems' Intelligence, France

America

• W. Reynolds, Sandford Burnham Prebys Medical Discovery Institute, USA
• P. Bisch, Instituto de Biofísica Carlos Chagas Filho da Universidade Federal do Rio de Janeiro

Africa

• A. Amine, Université Hassan II de Casablanca, Maroc
• B. Bayala, Université J. Ki Zerbo, Ouagadougou, Burkina Faso
• A. Boukhlouze, Faculté de Médecine et de Pharmacie, Rabat, Maroc
• M. Kiendrebeogo, Université J. Ki Zerbo, Ouagadougou, Burkina Faso
• M. Ouedraogo, Université J. Ki Zerbo, Ouagadougou, Burkina Faso
• I. Some, Université J. Ki Zerbo, Ouagadougou, Burkina Faso

2023

Andrea MONTIS, Metabolomics and quantitative RT-qPCR analysis for metabolite profiling of coffee plants: characterization of Coffea anthonyi

2022

Sofia OLIVEIRA RIBEIRO, Transformation d’huiles essentielles commerciales à visée antibactérienne

2021

Olga ROJO POVEDA, Valorisation of Compounds with High Nutritional Value from Cocoa By-Products as Food Ingredients and Additives

2019

Melissa CORTESE, Développement et validation du dosage de 9 nucléotides par couplage LC-MS/MS pour la recherche dans les maladies cardiovasculaires.

2018

Damien DUFOUR, Résolvine D1, cause ou conséquence des interactions entre macrophages et cellules endothéliales ?

2017

Caroline NOYON, La présence intrigante de la myéloperoxydase dans les cellules épithéliales de la prostate, serait-elle impliquée dans les lésions prostatiques ?

Sohely SIKDAR, Evaluation des effets du sulforaphane, de ses dérivés de synthèse et de l’acide α-lipoïque sur plusieurs systèmes de détoxification de modèles expérimentaux du vieillissement cellulaire cutané.

2016

Iyas ALDIB, Rational drug design approach of the myeloperoxidase inhibition: From in silico to pharmacological activity.

Ana PLANINC, Detection of changes in n-glycosylation profiles of therapeutic glycoproteins using LC-MS.

Jeremie NGEZAHAYO, Plantes médicinales du Burundi et maladies infectieuses: enquête ethnobotanique et activités antibactériennes directe et indirecte de composés isolés de Platostoma rotundifolium (Briq.) A. J. Paton (Lamiaceae).

Before 2016

Raïnatou BOLY, Caractérisation des propriétés anti-inflammatoires et anticancéreuses de la plante Agelanthus dodoneifolius (DC) Polh. & Wiens (Loranthaceae) utilisée en médecine traditionnelle au Burkina Faso.

Valérian BUNEL, Recherche de nouvelles substances naturelles d'intérêt dans la prévention de la fibrose rénale d'origine médicamenteuse.

Coraline CLAYES, Contribution à l'étude de la continuité des traitements médicamenteux des patients lors de leur sortie de l'hôpital.

Cédric DELPORTE, Etude des modifications de l'apolipoprotéine B-100 induites par la myéloperoxydase à l'aide de la chromatographie liquide couplée à la spectrométrie de masse.

Benjamin LALLEMAND, Development of novel anticancer glycyrrhetinic acid derivatives with marked anti tumor activity: synthesis and pharmacological evaluation of their activity.

Aminata NACOULMA, Reprogrammation métabolique induite dans les tissus hyperplasiques formés chez le tabac infecté par Rhodococcus fascians: aspects fondamentaux et applications.
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Philippe OKUSA NDJOLO, Etude phytochimique et activité antimicrobienne directe et indirecte de Cordia gilletii De Wild, Boraginaceae.

Nathalie PARIJ, Contribution à l'étude du pouvoir antioxydant des antiinflammatoires non stéroidiens.

Stéphanie PATRIS, Développement d'immunoessais associés aux électrodes sérigraphiées: des particules superparamagnétiques aux nanobodies.

Abdoul Karim SAKIRA, Contribution au développement d’électrodes miniaturisées pour le dosage de métaux lourds à l’état de trace dans les eaux de consommation.

Touridomo Issa SOME, Contribution à l'amélioration de modèles pour estimer les paramètres de stabilité de substances médicamenteuses : cas particuliers de l'acide acétylsalicylique

Jalal SOUBHYE, Design, synthesis and study of myeloperoxidase inhibitors in the series of 3-alkylindole.

Ahmad SARAKBI, Contribution to the development of electrochemical methods for liquid chromatographic analysis and drug quality monitoring.

Pierre VAN ANTWERPEN, Contribution à l'étude du pouvoir antioxydant de divers agents d’intérêt thérapeutique: Ciblage du système myéloperoxydase / peroxyde d'hydrogène / chlorure.

Francis VANDERBIST, Développement, optimisation et évaluation d'une formulation de nacystelyn, un nouvel agent mucoactif sous forme de poudre pour inhalation

Olivier VOSTERS, Contribution à l'étude du pouvoir antioxidant et des propriétés immunomodulatrices d'un composé à groupement thiol, le nacystelyn

Université Libre de Bruxelles
Faculty of Pharmacy
Plaine campus, CP 205/05
Building BC - Levels 6
Boulevard de Triomphe, access 2
1050 Brussels
Belgium
Phone : +32 (0) 2 650 52 63 
Email: pierre.van.antwerpen@ulb.be