From the fate and the action of a drug in the organism to its practical use by patients

Our research focuses on the pharmacokinetics and the pharmacodynamics of a drug, the interactions between drugs and natural products, the evaluation of pharmaceutical practices in hospitals and community pharmacies and on patient adherence to treatment.

About us


logo pharmacology






Our research team works in several domains from more fundamental to more practical ones.

  • Cardiovascular Pharmacology : We study the protection of the vascular endothelial function against different deleterious agents and evaluate the vasodilating and antioxidant activities of natural products.
  • Clinical Pharmacy: We assess the impact of clinical pharmacists on medication reconciliation.
  • Analysis, development and implementation of pharmaceutical services: We are interested in the detection and the resolution of drug-related problems in cancer patients. We evaluate the medication adherence in asthma and COPD and try to identify factors, key steps and necessary changes for optimal implementation of pharmaceutical services in community pharmacies. Other points of interest are the implementation of health screening in community pharmacies and the study of healthcare relationships.

Team

Senior scientists:
Pr. Stéphanie Pochet (1 ETP)
Pr. Carine De Vriese (1 ETP)
Pr. Frédéric Cotton (0.2 ETP)
Pr. Hugues Malonne (0.15 ETP)
Pr. Jean-Paul Dehaye (Professor of the University)

Post-doctoral fellows and scientific collaborators: 
Dr Florence Souard (1 ETP)
Dr Mélanie Lelubre 

Expert technician:
Charaf El Khattabi (1 ETP)

PhD students:
Natacha Biset (1 ETP)
Camille Hoornaert (0.5 ETP)
Sarah Rondeau (1 ETP)
Anne-Sophie Lechon (1 ETP)
 

Skills

Pharmacological skills Clinical skills
Isolated organ baths Quantitative and qualitative research methodologies (prospective/retrospective studies)
Biological tests (cytotoxic, antioxidant, ROS production tests, ...)  Pharmacoepidemiology
Cell cultures Online survey
Absorption test  Healthcare database analysis
Molecular biology techniques  Medication adherence measure
Implementation process analysis
Publications

- Implementation study of an intermediate medication review in Belgian community pharmacies. M. Lelubre, J. Wuyst, J. Maesschalck, N. Duquet, K. Foubert, J. Moullin, I. De Wulf, K. Boussery, V. Foulon, C. De Vriese. Research in Social Administrative Pharmacy, 2019; 15(6):710-723.

-  Adaptation and validation of the PCNE 6.2 classification in French-speaking Belgian community pharmacies. M. Koubaity, M. Lelubre, G. Sansterre, K. Amighi, C. De Vriese. International Journal of Clinical Pharmacy, 2019;41(1):244-250. 

- Étude pilote : évaluation de l’élargissement du rôle des assistants pharmaceutico-techniques et infirmiers dans le déploiement de l’anamnèse médicamenteuse dans le service des urgences. C. Hoornaert, S. Pochet, A. Vervacke, S. Lorent, J. Pharmacie clinique 2019; 38: 27-36.

-  Implementation study of an interprofessional medication adherence program for HIV patients in Switzerland: quantitative and qualitative implementation results. M. Lelubre, O. Clerc, M. Grosjean, K. Amighi, C. De Vriese, O. Bugnon, MP Schneider, BMC Health Serv Res. 2018 Nov 20;18(1):874.

- Implementation of an interprofessional medication adherence program for HIV patients: description of the process using the framework for the implementation of services in pharmacy. Lelubre M, Clerc O, Grosjean M, Amighi K, De Vriese C, Bugnon O, Schneider MP., BMC Health Serv Res. 2018 Sep 10;18(1):698.

- Evaluation of compliance with isotretinoin PPP recommendations and exploration of reasons for non-compliance: survey among French-speaking healthcare professionals and patients in Belgium. M. Lelubre, J. Hamdani, C. Senterre, K. Amighi, M. Peres, M. Schneider, O. Bugnon, C. De Vriese,  Pharmacoepidemiology and drug safety, 2018 Jun;27(6):668-673.

- Assessment of medication adherence and responsible use of isotretinoin and contraception through Belgian community pharmacies by using pharmacy refill data. N. Biset, M. Lelubre, C. Senterre, K. Amighi, O. Bugnon, M. Schneider, C. De Vriese, Patient preference and adherence, 2018, Jan 19;12:153-161.

- An open randomized controlled study comparing an online textbased scenario and a serious game by Belgian and Swiss pharmacy students. J. Berger, N. Bawab, J. De Mooij, D. Sutter Widmer, N. Szilas , C. De Vriese, O. Bugnon, Currents in Pharmacy Teaching and Learning, 2018 Mar;10(3):267-276.

- Effects of diesel exhaust particles on macrophage polarization. N. Labranche, C. El Khattabi, G. Berkenboom, S. Pochet. Hum. Exp. Toxicol., 2017; 36: 412-420.

- Rosuvastatin and vascular oxidative stress induced by diesel exhaust particles. N. Labranche, E. Youl, C. El Khattabi, L. Dewachter, N. Wauthoz, C. Delporte, G. Berkenboom, S. Pochet. Acta Cardiol., 2016; 71: 565-572.

- Vasorelaxant and antihypertensive effects of methanolic extracts from Hymenocardia acida Tul.,F. Nsuadi Manga, C. El Khattabi, J. Fontaine, G. Berkenboom, P. Duez, C. Noyon C, P. Van Antwerpen, J. Lami Nzunzu, S. Pochet. J Ethnopharmacol., 2013; 146: 623-631.

Thesis
  • Majda Koubaity: Drugs related problems in Belgium: from the community pharmacies to the hospital; State of the situation and impact: 2019
  • Mélanie Lelubre: Implementation study of professional pharmacy services in community pharmacies (co-tutelle avec l'Université de Genève): 2018
  • Nathalie Labranche: Les effets des microparticules diesel sur la fonction vasculaire : Décembre 2016
  • Francine Nsuadi Manga: Activités vasculaires et antioxydantes d'espèces des genres Combretum et Hymenocardia, plantes présumées antihypertensives à Kinshasa et dans le Bas-Congo: Mai 2013
Contacts

Pr. Stéphanie Pochet : spochet@ulb.ac.be
Pr. Carine De Vriese  : cdevries@ulb.ac.be

Updated on February 12, 2020