Department of Pharmacotherapy and Pharmaceutics (DPP)

Contact
 

Research activities

Véronique’s research activity is mainly focused on deciphering the mechanisms of action of potential anti-cancer compounds from natural origin. Indeed, Nature remains the first source of novel drug leads for anti-cancer purposes with ~60% of the drugs currently available actually inspired by Nature (Cragg and Newman, JNP 2016).

The evaluation and understanding of the cellular and molecular effects of such compounds is carried out in Véronique’s team, notably thanks to the use of different imaging tools such as live cell imaging.

Véronique is also developing this approach to evaluate the toxicity of compounds for other medical or nutraceutical applications. She leads a group in the frame of the ULB Cancer Research Centre (U-CRC)

Top ten recent articles

Herb-anticancer drug interactions in real life based on VigiBase, the WHO global database

Pochet, S., Lechon, A.-S., Lescrainier, C., De Vriese, C., Mathieu, V., Hamdani, J., & Souard, F. (2022). Herb-anticancer drug interactions in real life based on VigiBase, the WHO global database. Scientific reports, 12(1), 14178. doi:10.1038/s41598-022-17704-z  

 

Amaryllidaceae Alkaloids Decrease the Proliferation, Invasion, and Secretion of Clinically Relevant Cytokines by Cultured Human Colon Cancer Cells

Mathieu, V., Laguera, B., Masi, M., Dulanto, S. A., Bingham, T., Hernandez, L. W., Sarlah, D., Evidente, A., Lafontaine, D., Kornienko, A., & Lane, M. A. (2022). Amaryllidaceae Alkaloids Decrease the Proliferation, Invasion, and Secretion of Clinically Relevant Cytokines by Cultured Human Colon Cancer Cells. Biomolecules, 12(9), 1267. doi:10.3390/biom12091267  

 

In Vitro Effects of Fungal Phytotoxins on Cancer Cell Viability: First Insight into Structure Activity Relationship of a Potent Metabolite of Cochliobolus australiensis Radicinin

Mathieu, V., Superchi, S., Masi, M., Scafato, P., Kornienko, A., & Evidente, A. (2022). In Vitro Effects of Fungal Phytotoxins on Cancer Cell Viability: First Insight into Structure Activity Relationship of a Potent Metabolite of Cochliobolus australiensis Radicinin. Toxins, 14(8), 517. doi:10.3390/toxins14080517  

 

Self-assembled ruthenium and osmium nanosystems display a potent anticancer profile by interfering with metabolic activity

Marloye, M., Inam, H., Moore, C. J., Mertens, T. R., Ingels, A., Koch, M., Nowicki, M. O., Mathieu, V., Pritchard, J. R., Awuah, S. G., Lawler, S. E., Meyer, F., Dufrasne, F., & Berger, G. (2022). Self-assembled ruthenium and osmium nanosystems display a potent anticancer profile by interfering with metabolic activity. Inorganic Chemistry Frontiers. doi:10.1039/D2QI00423B  

 

Article In Vitro Antioxidant and Anticancer Properties of Various E. senegalensis Extracts

Fofana, S., Delporte, C., Calvo Esposito, R., Ouédraogo, M., Van Antwerpen, P., Guissou, I., Semdé, R., & Mathieu, V. (2022). Article In Vitro Antioxidant and Anticancer Properties of Various E. senegalensis Extracts. Molecules, 27(8), 2583. doi:10.3390/molecules27082583  

 

Polygodial and ophiobolin a analogues for covalent crosslinking of anticancer targets

Maslivetc, V., Laguera, B., Chandra, S., Dasari, R., Olivier, W. W., Smith, J., Bissember, A. A., Masi, M., Evidente, A., Mathieu, V., & Kornienko, A. (2021). Polygodial and ophiobolin a analogues for covalent crosslinking of anticancer targets. International journal of molecular sciences, 22(20), 11256. doi:10.3390/ijms222011256  

 

Antibacterial Activities of Homemade Matrices Miming Essential Oils Compared to Commercial Ones

Oliveira Ribeiro, S., Fontaine, V., Mathieu, V., Abdesselam, Z., Dominique, B., Caroline, S., & Souard, F. (2021). Antibacterial Activities of Homemade Matrices Miming Essential Oils Compared to Commercial Ones. Antibiotics, 10(5), 584. doi:10.3390/antibiotics10050584  

 

Priming of mesenchymal stem cells with a hydrosoluble form of curcumin allows keeping their mesenchymal properties for cell?based therapy development

Colin, M., Dechêne, L., Ceusters, J., Niesten, A., Demazy, C., Lagneaux, L., Zouaoui Boudjeltia, K., Franck, T., Van Antwerpen, P., Renard, P., Mathieu, V., & Serteyn, D. (2021). Priming of mesenchymal stem cells with a hydrosoluble form of curcumin allows keeping their mesenchymal properties for cell?based therapy development. Journal of Cellular and Molecular Medicine. doi:10.1111/jcmm.16403  

 

Antibacterial and Cytotoxic Activities of Ten Commercially Available Essential Oils

Oliveira Ribeiro, S., Fontaine, V., Mathieu, V., Stevigny, C., Souard, F., et al. (2020). Antibacterial and Cytotoxic Activities of Ten Commercially Available Essential Oils. Antibiotics, 9, 0717.  

 

Deciphering the chemical instability of sphaeropsidin A under physiological conditions-degradation studies and structural elucidation of the major metabolite

Van Der Westhuyzen, A. A., Ingels, A., Rosiere, R., Amighi, K., Oberer, L., Gustafson, K. K., Wang, D., Evidente, A., Maddau, L., Masi, M., De Villiers, A., Green, I. R., Berger, W., Kornienko, A., Mathieu, V., & Van Otterlo, W. W. (2020). Deciphering the chemical instability of sphaeropsidin A under physiological conditions-degradation studies and structural elucidation of the major metabolite. Organic & biomolecular chemistry, 18(40), 8147-8160. doi:10.1039/d0ob01586e