Department of Pharmacotherapy and Pharmaceutics (DPP)

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Research activities

Véronique’s research activity is mainly focused on deciphering the mechanisms of action of potential anti-cancer compounds from natural origin. Indeed, Nature remains the first source of novel drug leads for anti-cancer purposes with ~60% of the drugs currently available actually inspired by Nature (Cragg and Newman, JNP 2016).

The evaluation and understanding of the cellular and molecular effects of such compounds is carried out in Véronique’s team, notably thanks to the use of different imaging tools such as live cell imaging.

Véronique is also developing this approach to evaluate the toxicity of compounds for other medical or nutraceutical applications. She leads a group in the frame of the ULB Cancer Research Centre (U-CRC)

Top ten recent articles

Polygodial and ophiobolin a analogues for covalent crosslinking of anticancer targets

Maslivetc, V., Laguera, B., Chandra, S., Dasari, R., Olivier, W. W., Smith, J., Bissember, A. A., Masi, M., Evidente, A., Mathieu, V., & Kornienko, A. (2021). Polygodial and ophiobolin a analogues for covalent crosslinking of anticancer targets. International journal of molecular sciences, 22(20), 11256. doi:10.3390/ijms222011256  

 

Antibacterial Activities of Homemade Matrices Miming Essential Oils Compared to Commercial Ones

Oliveira Ribeiro, S., Fontaine, V., Mathieu, V., Abdesselam, Z., Dominique, B., Caroline, S., & Souard, F. (2021). Antibacterial Activities of Homemade Matrices Miming Essential Oils Compared to Commercial Ones. Antibiotics, 10(5), 584. doi:10.3390/antibiotics10050584  

 

Priming of mesenchymal stem cells with a hydrosoluble form of curcumin allows keeping their mesenchymal properties for cell?based therapy development

Colin, M., Dechêne, L., Ceusters, J., Niesten, A., Demazy, C., Lagneaux, L., Zouaoui Boudjeltia, K., Franck, T., Van Antwerpen, P., Renard, P., Mathieu, V., & Serteyn, D. (2021). Priming of mesenchymal stem cells with a hydrosoluble form of curcumin allows keeping their mesenchymal properties for cell?based therapy development. Journal of Cellular and Molecular Medicine. doi:10.1111/jcmm.16403  

 

Antibacterial and Cytotoxic Activities of Ten Commercially Available Essential Oils

Oliveira Ribeiro, S., Fontaine, V., Mathieu, V., Stevigny, C., Souard, F., et al. (2020). Antibacterial and Cytotoxic Activities of Ten Commercially Available Essential Oils. Antibiotics, 9, 0717.  

 

Deciphering the chemical instability of sphaeropsidin A under physiological conditions-degradation studies and structural elucidation of the major metabolite

Van Der Westhuyzen, A. A., Ingels, A., Rosière, R., Amighi, K., Oberer, L., Gustafson, K. K., Wang, D., Evidente, A., Maddau, L., Masi, M., De Villiers, A., Green, I. R., Berger, W., Kornienko, A., Mathieu, V., & Van Otterlo, W. W. (2020). Deciphering the chemical instability of sphaeropsidin A under physiological conditions-degradation studies and structural elucidation of the major metabolite. Organic & biomolecular chemistry, 18(40), 8147-8160. doi:10.1039/d0ob01586e  

 

Antiproliferative activity of naphthoquinones and indane carboxylic acids from lapachol against a panel of human cancer cell lines

Eyong, K. O., Ketsemen, H. H., Zhao, Z., Du, L., Ingels, A., Mathieu, V., Kornienko, A., Hull, K. K., Folefoc, G. N., Baskaran, S., & Romo, D. (2020). Antiproliferative activity of naphthoquinones and indane carboxylic acids from lapachol against a panel of human cancer cell lines. Medicinal chemistry research, 29(6), 1058-1066. doi:10.1007/s00044-020-02545-0  

 

A new potential anti?cancer beta?carboline derivative decreases the expression levels of key proteins involved in glioma aggressiveness: A proteomic investigation

De Carvalho, A., Viaene, J., Vandenbussche, G., De Braekeleer, K., Masereel, B., Wouters, J., Souard, F., Vander Heyden, Y., Van Antwerpen, P., Delporte, C., & Mathieu, V. (2020). A new potential anti?cancer beta?carboline derivative decreases the expression levels of key proteins involved in glioma aggressiveness: A proteomic investigation. Drug development research, 8(1), 32-42. doi:10.1002/ddr.21600  

 

Halogenated diterpenes with in vitro antitumor activity from the red alga sphaerococcus coronopifolius

Smyrniotopoulos, V., De Andrade Tomaz, A. C., De Fátima Vanderlei De Souza, M., Da Cunha, E. V. L., Kiss, R., Mathieu, V., Ioannou, E., & Roussis, V. (2020). Halogenated diterpenes with in vitro antitumor activity from the red alga sphaerococcus coronopifolius. Marine drugs, 18(1), 29. doi:10.3390/md18010029  

 

Oxygenated C17 polyacetylene metabolites from Algerian Eryngium tricuspidatum L. roots: Structure and biological activity

Djebara, A., Ciavatta, M. L., Mathieu, V., Colin, M., Bitam, F., Carbone, M., & Gavagnin, M. (2019). Oxygenated C17 polyacetylene metabolites from Algerian Eryngium tricuspidatum L. roots: Structure and biological activity. Fitoterapia, 138, 104355. doi:10.1016/j.fitote.2019.104355  

 

Tumor Targeting by Peptide-Decorated Gold Nanoparticles.

Albertini, B., Mathieu, V., Iraci, N., Van Woensel, M., Schoubben, A., Donnadio, A., Greco, S., Ricci, M., Temperini, A., Blasi, P., & Wauthoz, N. (2019). Tumor Targeting by Peptide-Decorated Gold Nanoparticles. Molecular pharmaceutics, 16(6), 2430-2444. doi:10.1021/acs.molpharmaceut.9b00047