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Véronique Mathieu
Department of Pharmacotherapy and Pharmaceutics (DPP)
ContactResearch activities
Véronique’s research activity is mainly focused on deciphering the mechanisms of action of potential anti-cancer compounds from natural origin. Indeed, Nature remains the first source of novel drug leads for anti-cancer purposes with ~60% of the drugs currently available actually inspired by Nature (Cragg and Newman, JNP 2016).
The evaluation and understanding of the cellular and molecular effects of such compounds is carried out in Véronique’s team, notably thanks to the use of different imaging tools such as live cell imaging.
Véronique is also developing this approach to evaluate the toxicity of compounds for other medical or nutraceutical applications. She leads a group in the frame of the ULB Cancer Research Centre (U-CRC)
Top ten recent articles
Herb-anticancer drug interactions in real life based on VigiBase, the WHO global database
Pochet, S., Lechon, A.-S., Lescrainier, C., De Vriese, C., Mathieu, V., Hamdani, J., & Souard, F. (2022). Herb-anticancer drug interactions in real life based on VigiBase, the WHO global database. Scientific reports, 12(1), 14178. doi:10.1038/s41598-022-17704-z
Amaryllidaceae Alkaloids Decrease the Proliferation, Invasion, and Secretion of Clinically Relevant Cytokines by Cultured Human Colon Cancer Cells
Mathieu, V., Laguera, B., Masi, M., Dulanto, S. A., Bingham, T., Hernandez, L. W., Sarlah, D., Evidente, A., Lafontaine, D., Kornienko, A., & Lane, M. A. (2022). Amaryllidaceae Alkaloids Decrease the Proliferation, Invasion, and Secretion of Clinically Relevant Cytokines by Cultured Human Colon Cancer Cells. Biomolecules, 12(9), 1267. doi:10.3390/biom12091267
In Vitro Effects of Fungal Phytotoxins on Cancer Cell Viability: First Insight into Structure Activity Relationship of a Potent Metabolite of Cochliobolus australiensis Radicinin
Mathieu, V., Superchi, S., Masi, M., Scafato, P., Kornienko, A., & Evidente, A. (2022). In Vitro Effects of Fungal Phytotoxins on Cancer Cell Viability: First Insight into Structure Activity Relationship of a Potent Metabolite of Cochliobolus australiensis Radicinin. Toxins, 14(8), 517. doi:10.3390/toxins14080517
Self-assembled ruthenium and osmium nanosystems display a potent anticancer profile by interfering with metabolic activity
Marloye, M., Inam, H., Moore, C. J., Mertens, T. R., Ingels, A., Koch, M., Nowicki, M. O., Mathieu, V., Pritchard, J. R., Awuah, S. G., Lawler, S. E., Meyer, F., Dufrasne, F., & Berger, G. (2022). Self-assembled ruthenium and osmium nanosystems display a potent anticancer profile by interfering with metabolic activity. Inorganic Chemistry Frontiers. doi:10.1039/D2QI00423B
Article In Vitro Antioxidant and Anticancer Properties of Various E. senegalensis Extracts
Fofana, S., Delporte, C., Calvo Esposito, R., Ouédraogo, M., Van Antwerpen, P., Guissou, I., Semdé, R., & Mathieu, V. (2022). Article In Vitro Antioxidant and Anticancer Properties of Various E. senegalensis Extracts. Molecules, 27(8), 2583. doi:10.3390/molecules27082583
Polygodial and ophiobolin a analogues for covalent crosslinking of anticancer targets
Maslivetc, V., Laguera, B., Chandra, S., Dasari, R., Olivier, W. W., Smith, J., Bissember, A. A., Masi, M., Evidente, A., Mathieu, V., & Kornienko, A. (2021). Polygodial and ophiobolin a analogues for covalent crosslinking of anticancer targets. International journal of molecular sciences, 22(20), 11256. doi:10.3390/ijms222011256
Antibacterial Activities of Homemade Matrices Miming Essential Oils Compared to Commercial Ones
Oliveira Ribeiro, S., Fontaine, V., Mathieu, V., Abdesselam, Z., Dominique, B., Caroline, S., & Souard, F. (2021). Antibacterial Activities of Homemade Matrices Miming Essential Oils Compared to Commercial Ones. Antibiotics, 10(5), 584. doi:10.3390/antibiotics10050584
Priming of mesenchymal stem cells with a hydrosoluble form of curcumin allows keeping their mesenchymal properties for cell‐based therapy development
Colin, M., Dechêne, L., Ceusters, J., Niesten, A., Demazy, C., Lagneaux, L., Zouaoui Boudjeltia, K., Franck, T., Van Antwerpen, P., Renard, P., Mathieu, V., & Serteyn, D. (2021). Priming of mesenchymal stem cells with a hydrosoluble form of curcumin allows keeping their mesenchymal properties for cell‐based therapy development. Journal of Cellular and Molecular Medicine. doi:10.1111/jcmm.16403
Antibacterial and Cytotoxic Activities of Ten Commercially Available Essential Oils
Oliveira Ribeiro, S., Fontaine, V., Mathieu, V., Stevigny, C., Souard, F., et al. (2020). Antibacterial and Cytotoxic Activities of Ten Commercially Available Essential Oils. Antibiotics, 9, 0717.
Deciphering the chemical instability of sphaeropsidin A under physiological conditions-degradation studies and structural elucidation of the major metabolite
Van Der Westhuyzen, A. A., Ingels, A., Rosiere, R., Amighi, K., Oberer, L., Gustafson, K. K., Wang, D., Evidente, A., Maddau, L., Masi, M., De Villiers, A., Green, I. R., Berger, W., Kornienko, A., Mathieu, V., & Van Otterlo, W. W. (2020). Deciphering the chemical instability of sphaeropsidin A under physiological conditions-degradation studies and structural elucidation of the major metabolite. Organic & biomolecular chemistry, 18(40), 8147-8160. doi:10.1039/d0ob01586e
Career
- Assistant Professor in the Laboratoire de Cancérologie et Toxicologie Expérimentale, Université Libre de Bruxelles (octobre 2011-)
- Post-Doctoral Fellow (« Chargé de Recherche ») at the « Fonds National de la Recherche Scientifique »: Université Libre de Bruxelles, Laboratory of Toxicology, Faculty of Pharmacy and FATH, Pharmacy Faculty, Université Catholique de Louvain (2009-2011)
- Post-Doctoral Fellow (Yvonne Boël Fundation) : Université Libre de Bruxelles, Laboratory of Toxicology, Faculty of Pharmacy (2007-2009)
- Medicine and Laboratory Animal Sciences Certificate: Université Catholique de Louvain (2009), Belgium
- PhD in Biomedical Sciences, Pharmaceutical applications section: Université Libre de Bruxelles, Laboratory of Toxicology, Faculty of Pharmacy (2003-2007), Belgium
- Physician, Université Libre de Bruxelles (1995-2002), Belgium