Research in Drug Development (RD3)

Pharmacognosy Bioanalysis and Drug Discovery


Research activities

His first research interests focus on the validation of myeloperoxidase as a therapeutical target. In this context, part of his research is also dedicated to the inhibition of myeloperoxidase by chemical screening and rational drug design approach. Since 2008, his main task has been the development of the analytical platform of the Faculty of Pharmacy (ULB) and especially the mass spectrometry. Beside the myeloperoxidase research topic, method validations suitable for the pharmaceutical and biomedical researches are the main part of his actual activities: oxidized peptide quantifications, glycobiology, proteomics, metabolomics, lipidomics, small molecules analysis...

Top ten recent articles

Cortese, M., Delporte, C., Dufour, D., Noyon, C., Chaumont, M., De Becker, B., Reye, F., Rousseau, A., Eker, O. F., Neve, J., Piagnerelli, M., Zouaoui Boudjeltia, K., Robaye, B., & Van Antwerpen, P. (2019). Validation of a LC/MSMS method for simultaneous quantification of 9 nucleotides in biological matrices. Talanta, 193, 206-214. doi:10.1016/j.talanta.2018.10.003

Medfai, H., Khalil, A., Rousseau, A., Nuyens, V., Paumann-Page, M., Sevcnikar, B., Furtmüller, P. G., Obinger, C., Moguilevsky, N., Peulen, O., Herfs, M., Castronovo, V., Amri, M., Van Antwerpen, P., Vanhamme, L., & Zouaoui Boudjeltia, K. (2018, juillet). Human peroxidasin 1 promotes angiogenesis through ERK1/2, Akt and FAK pathways. Cardiovascular Research. doi:10.1093/cvr/cvy179

Khalil,  A., Poelvoorde,  P., Fayyad-Kazan,  M., Rousseau, A., Nuyens,  V., Uzureau,  S., Biston, P., El-Makhour,  Y., Badran,  B., Van Antwerpen,  P., Zouaoui Boudjeltia,  K., & Vanhamme,  L. (2018, octobre). Apoliporotein L3 interferes with endothelial tube formation via regulation of ERK1/2, FAK and Akt signaling pathway. Atherosclerosis, 279, 73-87. doi:10.1016/j.atherosclerosis.2018.10.023

Dufour, D., Khalil, A., Nuyens, V., Rousseau, A., Delporte, C., Noyon, C., Cortese, M., Reye, F., Pireaux, V., Neve, J., Vanhamme, L., Robaye, B., Lelubre, C., Desmet, J.-M., Raes, M., Zouaoui Boudjeltia, K., & Van Antwerpen, P. (2018, mai). Native and myeloperoxidase-oxidized low-density lipoproteins act in synergy to induce release of resolvin-D1 from endothelial cells. Atherosclerosis, 272, 108-117. doi:10.1016/j.atherosclerosis.2018.03.012

Delporte, C., Zouaoui Boudjeltia,  K., Furtmueller,  P.  G., Maki, R., Dieu,  M., Noyon,  C., Soudi, M., Dufour,  D., Coremans,  C., Nuyens, V., Reye,  F., Rousseau,  A., Raes, M., Moguilevsky,  N., Vanhaeverbeek,  M., Ducobu, J., Neve,  J., Robaye,  B., Vanhamme,  L., Reynolds, W., Obinger,  C., & Van Antwerpen,  P. (2018, mars). Myeloperoxidase-catalyzed oxidation of cyanide to cyanate: A potential carbamylation route involved in the formation of atherosclerotic plaques? The Journal of biological chemistry. doi:10.1074/jbc.M117.801076

Souard,  F., Delporte,  C., Stoffelen,  P., Thévenot, E.  E., Noret,  N., Dauvergne,  B., Kauffmann, J.-M., Van Antwerpen,  P., & Stevigny,  C. (2018, avril). Metabolomics fingerprint of coffee species determined by untargeted-profiling study using LC-HRMS Food chemistry, 245, 603-612. doi:10.1016/j.foodchem.2017.10.022

Noyon,  C., Roumeguere,  T., Delporte,  C., Dufour, D., Cortese,  M., Desmet, J.-M., Lelubre,  C., Rousseau,  A., Poelvoorde,  P., Neve, J., Vanhamme,  L., Zouaoui Boudjeltia,  K., & Van Antwerpen,  P. (2017). The presence of modified nucleosides in extracellular fluids leads to the specific incorporation of 5-chlorocytidine into RNA and modulates the transcription and translation Molecular and cellular biochemistry, 429(1-2), 59-71. doi:10.1007/s11010-016-2936-2

Dawaliby, R., Trubbia,  C., Delporte,  C., Masureel, M., Van Antwerpen,  P., Kobilka,  B.  K., & Govaerts,  C. (2016, janvier 12). Allosteric regulation of G protein-coupled receptor activity by phospholipids. Nature Chemical Biology, 12(1), 1960, 35-39. doi:10.1038/nchembio.1960

Soudi,  M., Paumann-Page,  M., Delporte,  C., Pirker, K.  K., Bellei,  M., Edenhofer,  E., Stadlmayr,  G., Battistuzzi,  G., Zouaoui Boudjeltia,  K., Furtmüller,  P.  G., Van Antwerpen,  P., & Obinger,  C. (2015, février). Multidomain Human Peroxidasin 1 is a Highly Glycosylated and Stable Homotrimeric High-Spin Ferric Peroxidase. The Journal of biological chemistry. doi:10.1074/jbc.M114.632273

Delporte, C., Zouaoui Boudjeltia,  K., Noyon,  C., Furtmueller,  P.  G., Nuyens,  V., Slomianny, M.-C., Madhoun,  P., Desmet, J.-M., Raynal,  P., Dufour, D., Koyani,  C.  N., Reye,  F., Rousseau, A., Vanhaeverbeek,  M., Ducobu,  J., Michalski, J.-C., Neve,  J., Vanhamme, L., Obinger,  C., Malle,  E., & Van Antwerpen,  P. (2014, février). Impact of interaction between myeloperoxidase and low-density lipoprotein on the specific activity of the enzyme and subsequent post-translational oxidative modifications of apolipoprotein B-100. Journal of lipid research. doi:10.1194/jlr.M047449