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Marie Vandeput
Research in Drug Development (RD3), Pharmacognosy Bioanalysis and Drug Discovery
ContactRESEARCH ACTIVITIES
Her research fields deal with the development of innovative analytical methods looking for new technologies and at nano/microfluidics scale. Her main research is focused on methods using chromatography liquid coupled to mass spectrometry to characterize therapeutic proteins (biotherapeutic drugs) and biological proteins to study posttranslational modifications, especially glycosylation. Her research was also devoted to the development of “proof-of-concept” fluidic systems coupled to electrochemical detector which integrated a reactor such as an immobilized enzyme to study pharmaceutical and agri-food compounds. These customized systems were applied on drug screening looking at therapeutical inhibitors but also on the determination of xenobiotics
Selected publications
Fc Glycosylation Characterization of Human Immunoglobulins G Using Immunocapture and LC-MS.
Helali, Y., Sharma, S., Vandeput, M., Welba, D., Van Antwerpen, P., Marchant, A., & Delporte, C. (2021). Fc Glycosylation Characterization of Human Immunoglobulins G Using Immunocapture and LC-MS. Methods in molecular biology, 2271, 57-71. doi:10.1007/978-1-0716-1241-5_4
Isoniazid Bactericidal Activity Involves Electron Transport Chain Perturbation.
Zeng, S., Soetaert, K., Ravon, F., Vandeput, M., Bald, D., Kauffmann, J.-M., Mathys, V., Wattiez, R., & Fontaine, V. (2019). Isoniazid Bactericidal Activity Involves Electron Transport Chain Perturbation. Antimicrobial agents and chemotherapy, 63(3). doi:10.1128/AAC.01841-18
Isoniazid bactericidal activity involves electron transport chain perturbation
Zeng, S., Soetaert, K., Ravon, F., Vandeput, M., Bald, D., Kauffmann, J.-M., Mathys, V., Wattiez, R., & Fontaine, V. (2019). Isoniazid bactericidal activity involves electron transport chain perturbation. Antimicrobial agents and chemotherapy, 63(3), 1-20.
Electrochemical studies of ethoxyquin and its determination in salmon samples by flow injection analysis with an amperometric dual detector
Vandeput, M., Rodríguez-Gómez, R., Izere, A.-M., Zafra-Gomez, A., De Braekeleer, K., Delporte, C., Van Antwerpen, P., & Kauffmann, J.-M. (2018). Electrochemical studies of ethoxyquin and its determination in salmon samples by flow injection analysis with an amperometric dual detector. Electroanalysis, 30(30), 1293-1302. doi:10.1002/elan.201700611
Liquid chromatography-electrochemical detection for the determination of ethoxyquin and its dimer in pear skin and salmon samples
Rodríguez-Gómez, R., Vandeput, M., Zafra-Gomez, A., & Kauffmann, J.-M. (2018). Liquid chromatography-electrochemical detection for the determination of ethoxyquin and its dimer in pear skin and salmon samples. Talanta, 177, 157-162. doi:10.1016/j.talanta.2017.08.078
Electrochemical detectors in liquid chromatography: Recent trends in Pharmaceutical and Biomedical Analysis
Kauffmann, J.-M., Karadas-Bakirhan, N., Bozal-Palabiyik, B., Uslu, B., Rodríguez-Gómez, R., Vandeput, M., & Ozkan, S. (2017). Electrochemical detectors in liquid chromatography: Recent trends in Pharmaceutical and Biomedical Analysis. Current medicinal chemistry, 24. doi:10.2174/0929867324666170609074826
A Reduced Graphene Oxide-based Electrochemical DNA Biosensor for the Detection of Interaction between Cisplatin and DNA based on Guanine and Adenine Oxidation Signals
Yardim, Y., Vandeput, M., Çelebi, M., Senturk, Z., & Kauffmann, J.-M. (2017). A Reduced Graphene Oxide-based Electrochemical DNA Biosensor for the Detection of Interaction between Cisplatin and DNA based on Guanine and Adenine Oxidation Signals. Electroanalysis, 29(5), 1451-1458. doi:10.1002/elan.201600804
Application of a tyrosinase microreactor - detector in a flow injection configuration for the determination of affinity and dynamics of inhibitor binding
Vandeput, M., Patris, S., Silva, H., Parsajoo, C., Dejaegher, B., Arcos-Martínez, J. M., & Kauffmann, J.-M. (2017). Application of a tyrosinase microreactor - detector in a flow injection configuration for the determination of affinity and dynamics of inhibitor binding. Sensors and actuators B Chemical, 248, 385-394. doi:10.1016/j.snb.2017.03.156
Antibodies as target for affinity biosensors
Patris, S., Vandeput, M., & Kauffmann, J.-M. (2016). Antibodies as target for affinity biosensors. TrAC. Trends in analytical chemistry, 79, 239-246. doi:10.1016/j.trac.2015.12.005
Contribution of Electrochemistry to the Biomedical and Pharmaceutical Analytical Sciences.
Kauffmann, J.-M., Patris, S., Vandeput, M., Sarakbi, A., & Sakira, A. (2015). Contribution of Electrochemistry to the Biomedical and Pharmaceutical Analytical Sciences. Current Drug Delivery, 13(3), 371-377.
Career
- 2018 – 2021 : Post-doctoral fellowship at the RD3-Pharmacognosy, Bioanalysis & Drug Discovery Unit and at the Analytical Platform of the Faculty of Pharmacy (ULB)
- 2018 : PhD in Pharmaceutical and Biomedical Sciences – Louis Maricq award
- 2011-2018 : Research-Assistant at the Laboratory of Instrumental Analysis and Bioelectrochemistry under the supervision of Prof J-M Kauffmann (Faculty of Pharmacy, ULB)
- 2011 : Graduated as Pharmacist – Nedeljkovitch award (Faculty of Pharmacy, ULB)