Research in Drug Development (RD3), Pharmacognosy Bioanalysis and Drug Discovery

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RESEARCH ACTIVITIES

Her research fields deal with the development of innovative analytical methods looking for new technologies and at nano/microfluidics scale. Her main research is focused on methods using chromatography liquid coupled to mass spectrometry to characterize therapeutic proteins (biotherapeutic drugs) and biological proteins to study posttranslational modifications, especially glycosylation. Her research was also devoted to the development of “proof-of-concept” fluidic systems coupled to electrochemical detector which integrated a reactor such as an immobilized enzyme to study pharmaceutical and agri-food compounds. These customized systems were applied on drug screening looking at therapeutical inhibitors but also on the determination of xenobiotics

Selected publications


Fc Glycosylation Characterization of Human Immunoglobulins G Using Immunocapture and LC-MS.

Helali, Y., Sharma, S., Vandeput, M., Welba, D., Van Antwerpen, P., Marchant, A., & Delporte, C. (2021). Fc Glycosylation Characterization of Human Immunoglobulins G Using Immunocapture and LC-MS. Methods in molecular biology, 2271, 57-71. doi:10.1007/978-1-0716-1241-5_4  

 

Isoniazid Bactericidal Activity Involves Electron Transport Chain Perturbation.

Zeng, S., Soetaert, K., Ravon, F., Vandeput, M., Bald, D., Kauffmann, J.-M., Mathys, V., Wattiez, R., & Fontaine, V. (2019). Isoniazid Bactericidal Activity Involves Electron Transport Chain Perturbation. Antimicrobial agents and chemotherapy, 63(3). doi:10.1128/AAC.01841-18  

 

Isoniazid bactericidal activity involves electron transport chain perturbation

Zeng, S., Soetaert, K., Ravon, F., Vandeput, M., Bald, D., Kauffmann, J.-M., Mathys, V., Wattiez, R., & Fontaine, V. (2019). Isoniazid bactericidal activity involves electron transport chain perturbation. Antimicrobial agents and chemotherapy, 63(3), 1-20.  

 

Electrochemical studies of ethoxyquin and its determination in salmon samples by flow injection analysis with an amperometric dual detector

Vandeput, M., Rodríguez-Gómez, R., Izere, A.-M., Zafra-Gomez, A., De Braekeleer, K., Delporte, C., Van Antwerpen, P., & Kauffmann, J.-M. (2018). Electrochemical studies of ethoxyquin and its determination in salmon samples by flow injection analysis with an amperometric dual detector. Electroanalysis, 30(30), 1293-1302. doi:10.1002/elan.201700611  

 

Liquid chromatography-electrochemical detection for the determination of ethoxyquin and its dimer in pear skin and salmon samples

Rodríguez-Gómez, R., Vandeput, M., Zafra-Gomez, A., & Kauffmann, J.-M. (2018). Liquid chromatography-electrochemical detection for the determination of ethoxyquin and its dimer in pear skin and salmon samples. Talanta, 177, 157-162. doi:10.1016/j.talanta.2017.08.078  

 

Electrochemical detectors in liquid chromatography: Recent trends in Pharmaceutical and Biomedical Analysis

Kauffmann, J.-M., Karadas-Bakirhan, N., Bozal-Palabiyik, B., Uslu, B., Rodríguez-Gómez, R., Vandeput, M., & Ozkan, S. (2017). Electrochemical detectors in liquid chromatography: Recent trends in Pharmaceutical and Biomedical Analysis. Current medicinal chemistry, 24. doi:10.2174/0929867324666170609074826  

 

A Reduced Graphene Oxide-based Electrochemical DNA Biosensor for the Detection of Interaction between Cisplatin and DNA based on Guanine and Adenine Oxidation Signals

Yardim, Y., Vandeput, M., Çelebi, M., Senturk, Z., & Kauffmann, J.-M. (2017). A Reduced Graphene Oxide-based Electrochemical DNA Biosensor for the Detection of Interaction between Cisplatin and DNA based on Guanine and Adenine Oxidation Signals. Electroanalysis, 29(5), 1451-1458. doi:10.1002/elan.201600804  

 

Application of a tyrosinase microreactor - detector in a flow injection configuration for the determination of affinity and dynamics of inhibitor binding

Vandeput, M., Patris, S., Silva, H., Parsajoo, C., Dejaegher, B., Arcos-Martínez, J. M., & Kauffmann, J.-M. (2017). Application of a tyrosinase microreactor - detector in a flow injection configuration for the determination of affinity and dynamics of inhibitor binding. Sensors and actuators B Chemical, 248, 385-394. doi:10.1016/j.snb.2017.03.156  

 

Antibodies as target for affinity biosensors

Patris, S., Vandeput, M., & Kauffmann, J.-M. (2016). Antibodies as target for affinity biosensors. TrAC. Trends in analytical chemistry, 79, 239-246. doi:10.1016/j.trac.2015.12.005  

 

Contribution of Electrochemistry to the Biomedical and Pharmaceutical Analytical Sciences.

Kauffmann, J.-M., Patris, S., Vandeput, M., Sarakbi, A., & Sakira, A. (2015). Contribution of Electrochemistry to the Biomedical and Pharmaceutical Analytical Sciences. Current Drug Delivery, 13(3), 371-377.