Research in Drug Development (RD3)

Pharmacognosy Bioanalysis and Drug Discovery

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Research activities

My research are focused on : chemometrics for multivariate analysis of data matrices obtained with hyphenated and spectroscopic techniques in different fields of life science.

Top ten recent articles

An infrared spectroscopic approach to characterise white powders, easily applicable in the context of drug checking, drug prevention and on?site analysis

Deconinck, E., Aït?Kaci, C., Raes, A., Canfyn, M., Bothy, J., Duchateau, C., Mees, C., De Braekeleer, K., Gremaux, L., & Blanckaert, P. (2020). An infrared spectroscopic approach to characterise white powders, easily applicable in the context of drug checking, drug prevention and on?site analysis. Drug Testing and Analysis. doi:10.1002/dta.2973  

 

CBD oils on the Belgian market: A validated MRM GC-MS/MS method for routine quality control using QuEChERS sample clean up

Duchateau, C., Canfyn, M., Desmedt, B., Kauffmann, J.-M., Stevigny, C., De Braekeleer, K., & Deconinck, E. (2020). CBD oils on the Belgian market: A validated MRM GC-MS/MS method for routine quality control using QuEChERS sample clean up. Journal of pharmaceutical and biomedical analysis, 205.  

 

Discrimination of legal and illegal Cannabis spp . according to European legislation using near infrared spectroscopy and chemometrics

Duchateau, C., Kauffmann, J.-M., Canfyn, M., Stevigny, C., De Braekeleer, K., & Deconinck, E. (2020). Discrimination of legal and illegal Cannabis spp . according to European legislation using near infrared spectroscopy and chemometrics. Drug Testing and Analysis. doi:10.1002/dta.2865  

 

Spectroscopic techniques combined with chemometrics for fast on-site characterization of suspected illegal antimicrobials

Tie, Y., Duchateau, C., Van de Steene, S., Mees, C., De Braekeleer, K., De Beer, T., Adams, E., & Deconinck, E. (2020). Spectroscopic techniques combined with chemometrics for fast on-site characterization of suspected illegal antimicrobials. Talanta, 217. doi:10.1016  

 

A new potential anti?cancer beta?carboline derivative decreases the expression levels of key proteins involved in glioma aggressiveness: A proteomic investigation

De Carvalho, A., Viaene, J., Vandenbussche, G., De Braekeleer, K., Masereel, B., Wouters, J., Souard, F., Vander Heyden, Y., Van Antwerpen, P., Delporte, C., & Mathieu, V. (2020). A new potential anti?cancer beta?carboline derivative decreases the expression levels of key proteins involved in glioma aggressiveness: A proteomic investigation. Drug development research, 8(1), 32-42. doi:10.1002/ddr.21600  

 

Determination of three main chlorogenic acids in water extracts of coffee leaves by liquid chromatography coupled to an electrochemical detector

Rodríguez-Gómez, R., Vanheuverzwjin, J., Souard, F., Delporte, C., Stevigny, C., Stoffelen, P., De Braekeleer, K., & Kauffmann, J.-M. (2018). Determination of three main chlorogenic acids in water extracts of coffee leaves by liquid chromatography coupled to an electrochemical detector. Antioxidants, 7(10), 143. doi:10.3390/antiox7100143  

 

Electrochemical studies of ethoxyquin and its determination in salmon samples by flow injection analysis with an amperometric dual detector

Vandeput, M., Rodríguez-Gómez, R., Izere, A.-M., Zafra-Gomez, A., De Braekeleer, K., Delporte, C., Van Antwerpen, P., & Kauffmann, J.-M. (2018). Electrochemical studies of ethoxyquin and its determination in salmon samples by flow injection analysis with an amperometric dual detector. Electroanalysis, 30(30), 1293-1302. doi:10.1002/elan.201700611  

 

Identification of coffee leaves using FT-NIR spectroscopy and SIMCA

Mees, C., Souard, F., Delporte, C., Deconinck, E., Stoffelen, P., Stevigny, C., Kauffmann, J.-M., & De Braekeleer, K. (2018). Identification of coffee leaves using FT-NIR spectroscopy and SIMCA. Talanta, 177, 4-11. doi:10.1016/j.talanta.2017.09.056  

 

Bisacodyl als laxativum in de Belgische apotheek

De Braekeleer, K. (2016). Bisacodyl als laxativum in de Belgische apotheek. Farmaceutisch tijdschrift voor België,(2).  

 

Ethinylestradiol and levonorgestrel preparations on the Belgian market: A comparitive study

Vanheusden, V., De Braekeleer, K., & Corthout, J. (2012). Ethinylestradiol and levonorgestrel preparations on the Belgian market: A comparitive study. Farmaceutisch tijdschrift voor België, 1.