Research in Drug Development (RD3)

Pharmacognosy Bioanalysis and Drug Discovery

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Research activities

My research are focused on : chemometrics for multivariate analysis of data matrices obtained with hyphenated and spectroscopic techniques in different fields of life science.

Top ten recent articles

Quality Control and Authentication of Argan Oils : Application of advanced Analytical Techniques

Elmaouardi, M., De Braekeleer, K., Vander Heyden, P., & Bouklouze, A. (2023). Quality Control and Authentication of Argan Oils : Application of advanced Analytical Techniques. Molecules. doi:doi.org/10.3390/molecules28041818  

 

Discrepancies between validated GC‐FID and UHPLC‐DAD methods for the analysis of Δ‐9‐THC and CBD in dried hemp flowers

Duchateau, C., De Leersnijder, C., Barhdadi, S., Canfyn, M., De Braekeleer, K., & Deconinck, E. (2022). Discrepancies between validated GC‐FID and UHPLC‐DAD methods for the analysis of Δ‐9‐THC and CBD in dried hemp flowers. Drug Testing and Analysis. doi:10.1002/dta.3354  

 

Relative response factors and multiple regression models in liquid chromatography to quantify low-dosed components using alternative standards—proof of concept: total Δ9-THC content in cannabis flowers using CBD as reference

De Leersnijder, C., Duchateau, C., De Braekeleer, K., & Deconinck, E. (2022). Relative response factors and multiple regression models in liquid chromatography to quantify low-dosed components using alternative standards—proof of concept: total Δ9-THC content in cannabis flowers using CBD as reference. Analytical and Bioanalytical Chemistry. doi:10.1007/s00216-022-04208-y  

 

Contents of amoxillin drugs dispensed in Goma, Democratic Republic of Congo

Busha Tibasima, E., De Braekeleer, K., & Deconinck, É. E. (2022). Contents of amoxillin drugs dispensed in Goma, Democratic Republic of Congo. African journal of pharmacy and pharmaceutical sciences. doi:doi.org/10.51483/AFJPS.2.1.2022.14-22  

 

Benchtop NIR standardization on handheld spectrometers to identify paracetamol tablets

Mees, C., Kauffmann, J.-M., Pierna, J. A. F., & De Braekeleer, K. (2022). Benchtop NIR standardization on handheld spectrometers to identify paracetamol tablets. Journal of chemometrics. doi:doi.org/10.1002/cem.3389  

 

Determination of the quality of metronidazole formulations by near-infrared spectrophotometric analysis

Sakaria, A. K., Mees, C., & De Braekeleer, K. (2021). Determination of the quality of metronidazole formulations by near-infrared spectrophotometric analysis. Talanta Open. doi:https://doi.org/10.1016/j.talo.2020.100027  

 

An infrared spectroscopic approach to characterise white powders, easily applicable in the context of drug checking, drug prevention and on‐site analysis

Deconinck, E., Aït‐Kaci, C., Raes, A., Canfyn, M., Bothy, J., Duchateau, C., Mees, C., De Braekeleer, K., Gremaux, L., & Blanckaert, P. (2020). An infrared spectroscopic approach to characterise white powders, easily applicable in the context of drug checking, drug prevention and on‐site analysis. Drug Testing and Analysis. doi:10.1002/dta.2973  

 

CBD oils on the Belgian market: A validated MRM GC-MS/MS method for routine quality control using QuEChERS sample clean up

Duchateau, C., Canfyn, M., Desmedt, B., Kauffmann, J.-M., Stevigny, C., De Braekeleer, K., & Deconinck, E. (2020). CBD oils on the Belgian market: A validated MRM GC-MS/MS method for routine quality control using QuEChERS sample clean up. Journal of pharmaceutical and biomedical analysis, 205.  

 

Discrimination of legal and illegal Cannabis spp . according to European legislation using near infrared spectroscopy and chemometrics

Duchateau, C., Kauffmann, J.-M., Canfyn, M., Stevigny, C., De Braekeleer, K., & Deconinck, E. (2020). Discrimination of legal and illegal Cannabis spp . according to European legislation using near infrared spectroscopy and chemometrics. Drug Testing and Analysis. doi:10.1002/dta.2865  

 

Spectroscopic techniques combined with chemometrics for fast on-site characterization of suspected illegal antimicrobials

Tie, Y., Duchateau, C., Van de Steene, S., Mees, C., De Braekeleer, K., De Beer, T., Adams, E., & Deconinck, E. (2020). Spectroscopic techniques combined with chemometrics for fast on-site characterization of suspected illegal antimicrobials. Talanta, 217. doi:10.1016