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Kris De Braekeleer
Research in Drug Development (RD3)
Pharmacognosy Bioanalysis and Drug Discovery
ContactResearch activities
My research are focused on : chemometrics for multivariate analysis of data matrices obtained with hyphenated and spectroscopic techniques in different fields of life science.
Top ten recent articles
Discrepancies between validated GC?FID and UHPLC?DAD methods for the analysis of ??9?THC and CBD in dried hemp flowers
Duchateau, C., De Leersnijder, C., Barhdadi, S., Canfyn, M., De Braekeleer, K., & Deconinck, E. (2022). Discrepancies between validated GC?FID and UHPLC?DAD methods for the analysis of ??9?THC and CBD in dried hemp flowers. Drug Testing and Analysis. doi:10.1002/dta.3354
Relative response factors and multiple regression models in liquid chromatography to quantify low-dosed components using alternative standards?proof of concept: total ?9-THC content in cannabis flowers using CBD as reference
De Leersnijder, C., Duchateau, C., De Braekeleer, K., & Deconinck, E. (2022). Relative response factors and multiple regression models in liquid chromatography to quantify low-dosed components using alternative standards?proof of concept: total ?9-THC content in cannabis flowers using CBD as reference. Analytical and Bioanalytical Chemistry. doi:10.1007/s00216-022-04208-y
An infrared spectroscopic approach to characterise white powders, easily applicable in the context of drug checking, drug prevention and on?site analysis
Deconinck, E., Aït?Kaci, C., Raes, A., Canfyn, M., Bothy, J., Duchateau, C., Mees, C., De Braekeleer, K., Gremaux, L., & Blanckaert, P. (2020). An infrared spectroscopic approach to characterise white powders, easily applicable in the context of drug checking, drug prevention and on?site analysis. Drug Testing and Analysis. doi:10.1002/dta.2973
CBD oils on the Belgian market: A validated MRM GC-MS/MS method for routine quality control using QuEChERS sample clean up
Duchateau, C., Canfyn, M., Desmedt, B., Kauffmann, J.-M., Stevigny, C., De Braekeleer, K., & Deconinck, E. (2020). CBD oils on the Belgian market: A validated MRM GC-MS/MS method for routine quality control using QuEChERS sample clean up. Journal of pharmaceutical and biomedical analysis, 205.
Discrimination of legal and illegal Cannabis spp . according to European legislation using near infrared spectroscopy and chemometrics
Duchateau, C., Kauffmann, J.-M., Canfyn, M., Stevigny, C., De Braekeleer, K., & Deconinck, E. (2020). Discrimination of legal and illegal Cannabis spp . according to European legislation using near infrared spectroscopy and chemometrics. Drug Testing and Analysis. doi:10.1002/dta.2865
Spectroscopic techniques combined with chemometrics for fast on-site characterization of suspected illegal antimicrobials
Tie, Y., Duchateau, C., Van de Steene, S., Mees, C., De Braekeleer, K., De Beer, T., Adams, E., & Deconinck, E. (2020). Spectroscopic techniques combined with chemometrics for fast on-site characterization of suspected illegal antimicrobials. Talanta, 217. doi:10.1016
A new potential anti?cancer beta?carboline derivative decreases the expression levels of key proteins involved in glioma aggressiveness: A proteomic investigation
De Carvalho, A., Viaene, J., Vandenbussche, G., De Braekeleer, K., Masereel, B., Wouters, J., Souard, F., Vander Heyden, Y., Van Antwerpen, P., Delporte, C., & Mathieu, V. (2020). A new potential anti?cancer beta?carboline derivative decreases the expression levels of key proteins involved in glioma aggressiveness: A proteomic investigation. Drug development research, 8(1), 32-42. doi:10.1002/ddr.21600
Determination of three main chlorogenic acids in water extracts of coffee leaves by liquid chromatography coupled to an electrochemical detector
Rodríguez-Gómez, R., Vanheuverzwjin, J., Souard, F., Delporte, C., Stevigny, C., Stoffelen, P., De Braekeleer, K., & Kauffmann, J.-M. (2018). Determination of three main chlorogenic acids in water extracts of coffee leaves by liquid chromatography coupled to an electrochemical detector. Antioxidants, 7(10), 143. doi:10.3390/antiox7100143
Electrochemical studies of ethoxyquin and its determination in salmon samples by flow injection analysis with an amperometric dual detector
Vandeput, M., Rodríguez-Gómez, R., Izere, A.-M., Zafra-Gomez, A., De Braekeleer, K., Delporte, C., Van Antwerpen, P., & Kauffmann, J.-M. (2018). Electrochemical studies of ethoxyquin and its determination in salmon samples by flow injection analysis with an amperometric dual detector. Electroanalysis, 30(30), 1293-1302. doi:10.1002/elan.201700611
Identification of coffee leaves using FT-NIR spectroscopy and SIMCA
Mees, C., Souard, F., Delporte, C., Deconinck, E., Stoffelen, P., Stevigny, C., Kauffmann, J.-M., & De Braekeleer, K. (2018). Identification of coffee leaves using FT-NIR spectroscopy and SIMCA. Talanta, 177, 4-11. doi:10.1016/j.talanta.2017.09.056
Career
- 2016-... Professor
- 2001–2016 : Manager of a laboratory division (AAS/AES, UV-VIS spectroscopy, UPLC, HPLC, Dissolution tests) in the Belgian pharmacist’s post-marketing control laboratory (Dienst voor Geneesmiddelenonderzoek / Service de Contrôle des Médicaments)
- 1999-2001 : Post-doc at Pfizer Global Research and Development, Sandwich, Kent, U.K. Chemometric techniques (Multivariate Curve Resolution) applied on data recorded with hyphenated techniques (HPLC-DAD, HPLC-DAD_MS) and spectroscopic techniques (Near infrared spectra)
- 1995-1999 : Assistant in the Department of Analytical Chemistry and Pharmaceutical technology (VUB)
- 1995-1999 : PhD in Pharmaceutical Sciences, (Title : « Multivariate Techniques for Purity Assessment and Pharmaceutical Reaction Monitoring » ), Department of Analytical Chemistry and Pharmaceutical Technology (VUB)
- 1997 (15-31 July) : Research stage (HPLC-DAD data analysis with Multivariate Curve Resolution) at the Department of Analytical Chemistry at the University of Barcelona
- 1995-1998 : Doctoral training in Pharmaceutical Sciences (VUB)
- 1991-1995 : Pharmacist graduated with great disdinction at the Free University of Brussels (VUB, Belgium)