Research in Drug Development (RD3)

Pharmacognosy Bioanalysis and Drug Discovery

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Research activities

My research are focused on : chemometrics for multivariate analysis of data matrices obtained with hyphenated and spectroscopic techniques in different fields of life science.

Top ten recent articles

  1. Garrido Frenich, M. Martínez Galera, J.L. Martínez Vidal, D.L. Massart, J.R. Torres-Lapasío, K. De Braekeleer, Ji-Hong Wang and P.K. Hopke, Resolution of multicomponent peaks by multicomponent projection approach, positive matrix factorization and alternating least squares, Analytica Chimica Acta, 411 (2000) 145-155.
  2. K. De Braekeleer, A. De Juan, F. Cuesta Sánchez, P.A. Hailey, D.C.A. Sharp, P. Dunn and D.L. Massart, Determination of the end point of a chemical synthesis process using on-line measured mid-infrared spectra, Applied Spectroscopy 54 (2000) 601-607.
  3. K. De Braekeleer, J.R. Torres-Lapasío and D.L. Massart, Improved purity assessment of high-performance liquid chromatography diode array detection data for overcoming the presence of the non-linearity artefact, Chemometrics and Intelligent Laboratory Systems 52 (2000) 45-59.
  4. Garrido Frenich, J.R. Torres-Lapasío, K. De Braekeleer, D.L. Massart, J.L. Martínez Vidal and M. Martínez Galera, Application of several modified peak purity assays to real complex multicomponent mixtures by high-performance liquid chromatography with diode-array detection, Journal of Chromatography A, 855 (1999) 487-499.
  5. K. De Braekeleer, R. De Maesschalck, P.A. Hailey, D.C.A. Sharp and D.L. Massart, On-line application of the orthogonal projection approach (OPA) and the soft independent modelling of class analogy approach (SIMCA) for the detection of the end point of a polymorph conversion reaction, by near infrared spectroscopy (NIR), Chemometrics and Intelligent Laboratory Systems, 46 (1999) 103-116.
  6. Y. Vander Heyden, K. De Braekeleer, Y. Zhu, E. Roets, J. Hoogmartens, J. De Beer and D.L. Massart, Nested Designs in Ruggedness testing, Journal of Pharmaceutical and Biomedical Analysis, 20 (1999) 875-887.
  7. K. De Braekeleer, A. De Juan and D.L. Massart, Purity assessment and resolution of tetracycline hydrochloride samples using high-performance liquid chromatography with diode array detection, Journal of Chromatography A, 832 (1998) 67-86.
  8. K. De Braekeleer, F. Cuesta Sánchez, P.A. Hailey, D.C.A. Sharp, A.J. Pettman and D.L. Massart, Influence and correction of temperature perturbations on NIR spectra during the monitoring of a polymorph conversion process prior to self-modelling mixture analysis, Journal of Biomedical and Pharmaceutical Analysis, 17 (1998) 141-152.
  9. K. De Braekeleer and D.L. Massart, Evaluation of the orthogonal projection approach (OPA) and the SIMPLISMA approach on the Windig standard spectral data sets, chemometrics and Intelligent Laboratory Systems, 39 (1997) 127-141.
  10. V. Vanheusden, K. De Braekeleer, J. Corthout, Ethinylestradiol and levonorgestrel preparations on the Belgian market: A comparative study, Farmaceutisch Tijdschrift voor België, Nr 1, maart 2012.