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Karim Amighi
Département de Pharmacothérapie et de pharmacie galénique - Unité de pharmacie galénique et de biopharmacie
ContactRESEARCH ACTIVITIES
His research interests are in the field of the formulation and in vitro/in vivo evaluation of advanced drug delivery systems for oral, parenteral, pulmonary, and nasal routes of administration. His research programme on lung drug delivery ranges from in vitro evaluation, through to evaluation of new excipients and/or devices, particle engineering and production using novel processes, and aerosol formulation, to in vivo scintigraphy imaging of lung deposition, local and systemic drug bioavailability, and clinical outcomes.
He has been responsible for more than 50 competitive research projects financed by regional funds or by national and international pharmaceuticals companies (budget > 15M €). He has initiated recently the launch of a new spin-off company (InhaTarget Therapeutics) in lung cancer targeted therapy field, and the marketing of a new inhalation product for the treatment of COPD.
Selected publications
Inhaled cytotoxic chemotherapy: clinical challenges, recent developments, and future prospects
Wauthoz, N., Rosiere, R., & Amighi, K. (2020). Inhaled cytotoxic chemotherapy: clinical challenges, recent developments, and future prospects. Expert opinion on drug delivery. doi:10.1080/17425247.2021.1829590
Development of siRNA-loaded chitosan nanoparticles targeting Galectin-1 for the treatment of gliobmastoma multiforme via intranasal administration
Van Woensel, M., Wauthoz, N., Rosiere, R., Mathieu, V., Kiss, R., Lefranc, F., Steelant, B., Van Gool, S. W., Mathivet, T., Gerhardt, H., Amighi, K., & De Vleeschouwer, S. (2016). Development of siRNA-loaded chitosan nanoparticles targeting Galectin-1 for the treatment of gliobmastoma multiforme via intranasal administration. Journal of controlled release, 227, 71-81. doi:10.1016/j.jconrel.2016.02.032
Development of Controlled-Release Cisplatin Dry Powders for Inhalation against Lung Cancers
Levet, V., Rosiere, R., Merlos, R., Fusaro, L., Berger, G., Amighi, K., & Wauthoz, N. (2016). Development of Controlled-Release Cisplatin Dry Powders for Inhalation against Lung Cancers. International journal of pharmaceutics, 515(1-2), 209-220. doi:10.1016/j.ijpharm.2016.10.019
New Inhalation-Optimized Itraconazole Nanoparticle-Based Dry Powders for the Treatment of Invasive Pulmonary Aspergillosis
Duret, C., Wauthoz, N., Sebti, T., Vanderbist, F., & Amighi, K. (2012). New Inhalation-Optimized Itraconazole Nanoparticle-Based Dry Powders for the Treatment of Invasive Pulmonary Aspergillosis. International journal of nanomedicine, 7, 5475-5489. doi:10.2147/IJN.S34091
Lactose characteristics and the generation of the aerosol
Pilcer, G., Wauthoz, N., & Amighi, K. (2012). Lactose characteristics and the generation of the aerosol. Advanced drug delivery reviews, 64(3), doi:10.1016/j.addr.2011.05.003, 233-256.
Formulation strategy and use of excipients in pulmonary drug delivery.
Pilcer, G., & Amighi, K. (2010). Formulation strategy and use of excipients in pulmonary drug delivery. International journal of pharmaceutics, 392(1-2), 1-19. doi:10.1016/j.ijpharm.2010.03.017
Pharmacoscintigraphic and pharmacokinetic evaluation of tobramycin DPI formulations in cystic fibrosis patients
Pilcer, G., Goole, J., Van Gansbeke, B., Blocklet, D., Knoop, C., Vanderbist, F., & Amighi, K. (2008). Pharmacoscintigraphic and pharmacokinetic evaluation of tobramycin DPI formulations in cystic fibrosis patients. European journal of pharmaceutics and biopharmaceutics, 68(2), 413-421. doi:10.1016/j.ejpb.2007.05.005
Preparation and in vitro evaluation of lipidic carriers and fillers for inhalation
Sebti, T., & Amighi, K. (2006). Preparation and in vitro evaluation of lipidic carriers and fillers for inhalation. European journal of pharmaceutics and biopharmaceutics, 63(1), 51-58. doi:10.1016/j.ejpb.2005.11.003
Preparation and characterization of nanocrystals for solubility and dissolution rate enhancement of nifedipine
Hecq, J., Deleers, M., Fanara, D., Vranckx, H., & Amighi, K. (2005). Preparation and characterization of nanocrystals for solubility and dissolution rate enhancement of nifedipine. International journal of pharmaceutics, 299(1-2), 167-177. doi:10.1016/j.ijpharm.2005.05.014
Surfactant induced drug delivery based on the use of thermosensitive polymers
Eeckman, F., Moës, A., & Amighi, K. (2003). Surfactant induced drug delivery based on the use of thermosensitive polymers. Journal of controlled release, 88(1), 105-116. doi:10.1016/S0168-3659(02)00457-1

Career
- (2019-) Cofounder and member of the Board of InhaTarget Therapeutics
- (2015-) Full Professor at the Faculty of Pharmacy (ULB)
- (2011-2015) Dean of the Faculty of Pharmacy (ULB)
- (2009-2015) Professor at the Faculty of Pharmacy (ULB)
- (2007-2011) Vice-Dean of the Faculty of Pharmacy (ULB)
- (2001-) Director of the laboratory of Pharmaceutics and Biopharmaceutics, Faculty of Pharmacy (ULB)
- (1997-2001) Associate Professor at Faculty of Pharmacy (ULB)
- (1988-1997) Research Assistant, Faculty of Pharmacy (ULB)