Département de Pharmacothérapie et de pharmacie galénique - Unité de pharmacie galénique et de biopharmacie

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RESEARCH ACTIVITIES
 

His research interests are in the field of the formulation and in vitro/in vivo evaluation of advanced drug delivery systems for oral, parenteral, pulmonary, and nasal routes of administration. His research programme on lung drug delivery ranges from in vitro evaluation, through to evaluation of new excipients and/or devices, particle engineering and production using novel processes, and aerosol formulation, to in vivo scintigraphy imaging of lung deposition, local and systemic drug bioavailability, and clinical outcomes.

He has been responsible for more than 50 competitive research projects financed by regional funds or by national and international pharmaceuticals companies (budget > 15M €). He has initiated recently the launch of a new spin-off company (InhaTarget Therapeutics) in lung cancer targeted therapy field, and the marketing of a new inhalation product for the treatment of COPD.

Selected publications


Inhaled cytotoxic chemotherapy: clinical challenges, recent developments, and future prospects

Wauthoz, N., Rosière, R., & Amighi, K. (2020). Inhaled cytotoxic chemotherapy: clinical challenges, recent developments, and future prospects. Expert opinion on drug delivery. doi:10.1080/17425247.2021.1829590  

 

Development of siRNA-loaded chitosan nanoparticles targeting Galectin-1 for the treatment of gliobmastoma multiforme via intranasal administration

Van Woensel, M., Wauthoz, N., Rosiere, R., Mathieu, V., Kiss, R., Lefranc, F., Steelant, B., Van Gool, S. W., Mathivet, T., Gerhardt, H., Amighi, K., & De Vleeschouwer, S. (2016). Development of siRNA-loaded chitosan nanoparticles targeting Galectin-1 for the treatment of gliobmastoma multiforme via intranasal administration. Journal of controlled release, 227, 71-81. doi:10.1016/j.jconrel.2016.02.032  

 

Development of Controlled-Release Cisplatin Dry Powders for Inhalation against Lung Cancers

Levet, V., Rosiere, R., Merlos, R., Fusaro, L., Berger, G., Amighi, K., & Wauthoz, N. (2016). Development of Controlled-Release Cisplatin Dry Powders for Inhalation against Lung Cancers. International journal of pharmaceutics, 515(1-2), 209-220. doi:10.1016/j.ijpharm.2016.10.019  

 

New Inhalation-Optimized Itraconazole Nanoparticle-Based Dry Powders for the Treatment of Invasive Pulmonary Aspergillosis

Duret, C., Wauthoz, N., Sebti, T., Vanderbist, F., & Amighi, K. (2012). New Inhalation-Optimized Itraconazole Nanoparticle-Based Dry Powders for the Treatment of Invasive Pulmonary Aspergillosis. International journal of nanomedicine, 7, 5475-5489. doi:10.2147/IJN.S34091  

 

Lactose characteristics and the generation of the aerosol

Pilcer, G., Wauthoz, N., & Amighi, K. (2012). Lactose characteristics and the generation of the aerosol. Advanced drug delivery reviews, 64(3), doi:10.1016/j.addr.2011.05.003, 233-256.  

 

Formulation strategy and use of excipients in pulmonary drug delivery.

Pilcer, G., & Amighi, K. (2010). Formulation strategy and use of excipients in pulmonary drug delivery. International journal of pharmaceutics, 392(1-2), 1-19. doi:10.1016/j.ijpharm.2010.03.017  

 

Pharmacoscintigraphic and pharmacokinetic evaluation of tobramycin DPI formulations in cystic fibrosis patients

Pilcer, G., Goole, J., Van Gansbeke, B., Blocklet, D., Knoop, C., Vanderbist, F., & Amighi, K. (2008). Pharmacoscintigraphic and pharmacokinetic evaluation of tobramycin DPI formulations in cystic fibrosis patients. European journal of pharmaceutics and biopharmaceutics, 68(2), 413-421. doi:10.1016/j.ejpb.2007.05.005  

 

Preparation and in vitro evaluation of lipidic carriers and fillers for inhalation

Sebti, T., & Amighi, K. (2006). Preparation and in vitro evaluation of lipidic carriers and fillers for inhalation. European journal of pharmaceutics and biopharmaceutics, 63(1), 51-58. doi:10.1016/j.ejpb.2005.11.003  

 

Preparation and characterization of nanocrystals for solubility and dissolution rate enhancement of nifedipine

Hecq, J., Deleers, M., Fanara, D., Vranckx, H., & Amighi, K. (2005). Preparation and characterization of nanocrystals for solubility and dissolution rate enhancement of nifedipine. International journal of pharmaceutics, 299(1-2), 167-177. doi:10.1016/j.ijpharm.2005.05.014  

 

Surfactant induced drug delivery based on the use of thermosensitive polymers

Eeckman, F., Moës, A., & Amighi, K. (2003). Surfactant induced drug delivery based on the use of thermosensitive polymers. Journal of controlled release, 88(1), 105-116. doi:10.1016/S0168-3659(02)00457-1