Department of Drug Research and Development (DPP)

Therapeutic Chemistry (CPO)

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Research activities

His main research interests aim at creating new pharmaceutical forms, improving manufacturing processes and increasing the bioavailability of active molecules.

He is especially interested in: the development of solid dosage forms, including modified-release systems; the formulation of biotherapeutics, including encapsulated systems and implantable dosage forms; the solubility enhancement for poorly-soluble drugs, including the creation of amorphous structures, nanoparticules or solid-dispersions.

More recently, he focused a part of his research on the development of customized dosages forms made by 3D printing techniques especially dedicated to personalized therapies.

Top ten recent articles

3D printing in pharmaceutics: A new tool for designing customized drug delivery systems

Goole, J., & Amighi, K. (2016). 3D printing in pharmaceutics: A new tool for designing customized drug delivery systems. International journal of pharmaceutics, 499(1-2), 376-394. doi:10.1016/j.ijpharm.2015.12.071  

 

Development and evaluation of chitosan and chitosan derivative nanoparticles containing insulin for oral administration

Hecq, J., Siepmann, F., Siepmann, J., Amighi, K., & Goole, J. (2015). Development and evaluation of chitosan and chitosan derivative nanoparticles containing insulin for oral administration. Drug development and industrial pharmacy, 41(12), 2037-2044. doi:10.3109/03639045.2015.1044904  

 

Ciprofloxacin monoolein water gels as implants for the treatment of chronic osteomyelitis: In vitro characterization

Sombié, B., Yameogo, J., Semde, R., Henschel, V., Amighi, K., & Goole, J. (2014). Ciprofloxacin monoolein water gels as implants for the treatment of chronic osteomyelitis: In vitro characterization. Agricultura policy paper, 5(4), 158-163. doi:10.4103/2231-4040.143029  

 

Encapsulation of immunoglobulin G by solid-in-oil-in-water: Effect of process parameters on microsphere properties.

Marquette, S., Peerboom, C., Yates, A., Denis, L., Goole, J., & Amighi, K. (2013). Encapsulation of immunoglobulin G by solid-in-oil-in-water: Effect of process parameters on microsphere properties. European journal of pharmaceutics and biopharmaceutics. doi:10.1016/j.ejpb.2013.10.013  

 

Characterization and optimization of GMO-based gels with long term release for intraarticular administration.

Reeff, J., Gaignaux, A., Goole, J., Siepmann, J., Siepmann, F., Jérôme, C., Thomassin, J. M., De Vriese, C., & Amighi, K. (2013). Characterization and optimization of GMO-based gels with long term release for intraarticular administration. International journal of pharmaceutics, 451(1-2), 95-103. doi:10.1016/j.ijpharm.2013.04.079  

 

Synthesis and plasma pharmacokinetics in CD-1 mice of a 18β-glycyrrhetinic acid derivative displaying anti-cancer activity

Lallemand, B., Ouedraogo, M., Wauthoz, N., Lamkami, T., Mathieu, V., Jabin, I., Amighi, K., Kiss, R., Dubois, J., & Goole, J. (2013). Synthesis and plasma pharmacokinetics in CD-1 mice of a 18β-glycyrrhetinic acid derivative displaying anti-cancer activity. Journal of Pharmacy and Pharmacology, 65(3), 402-410. doi:10.1111/j.2042-7158.2012.01603.x  

 

Development and evaluation of sustained-release clonidine-loaded PLGA microparticles.

Gaignaux, A., Reeff, J., Siepmann, F., Siepmann, J., De Vriese, C., Goole, J., & Amighi, K. (2012). Development and evaluation of sustained-release clonidine-loaded PLGA microparticles. International journal of pharmaceutics, 437(1-2), 20-28. doi:10.1016/j.ijpharm.2012.08.006  

 

The effects of excipients on transporter mediated absorption.

Goole, J., Lindley, D. J., Roth, W., Carl, S. M., Amighi, K., Kauffmann, J.-M., & Knipp, G. T. (2010). The effects of excipients on transporter mediated absorption. International journal of pharmaceutics, 393(1-2), 17-31. doi:10.1016/j.ijpharm.2010.04.019  

 

Evaluation and floating enhancement of levodopa sustained release floating minitablets coated with insoluble acrylic polymer

Goole, J., Amighi, K., & Vanderbist, F. (2008). Evaluation and floating enhancement of levodopa sustained release floating minitablets coated with insoluble acrylic polymer. Drug development and industrial pharmacy, 34(8), 827-833. doi:10.1080/03639040801926683  

 

Development and evaluation of new multiple-unit levodopa sustained-release floating dosage forms

Goole, J., Vanderbist, F., & Amighi, K. (2007). Development and evaluation of new multiple-unit levodopa sustained-release floating dosage forms. International journal of pharmaceutics, 334(1-2), 35-41. doi:10.1016/j.ijpharm.2006.10.018