Research in Drug Development (RD3)

Pharmacognosy Bioanalysis and Drug Discovery

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Professor Jean-Michel Kauffmann was born in Arlon, Belgium, in 1954. He became a pharmacist from the University Libre de Bruxelles (ULB) in 1977 and earned a Ph.D. degree in pharmaceutical sciences in 1983 from the same University. He became Full Professor and Head of the laboratory of instrumental analysis and bioelectrochemistry at the Institute of Pharmacy of the University Libre de Bruxelles in 1992. He is currently (2019) head of the department of research in drug development at the Faculty of Pharmacy (ULB).

Research activities

His research interests include analytical chemistry in general and more specifically electroanalysis of compounds of pharmaceutical interest, modified electrodes and biosensors and electrochemical detectors development for flow injection and HPLC analyses.

He has published 175 original papers and 24 chapters related to electroanalysis and biosensors and edited one book in the field of electroanalysis in the biomedical and pharmaceutical sciences (Spinger-2015) and given more than 300 lectures at national and international meetings.

He is the Editor-in-Chief of Talanta since 1995 and a member of the Advisory Boards of Analytical Letters, Electroanalysis, Talanta Current Separations, Chimica Acta Turcica, J.Pharm.Belgique, FABAD, (J. Pharm. Sciences of Ankara), The Open Anal.Chem. Journal, Anal.Pharm.Française, Arabian J. Chem., Farmacia (Romanian review).

Top ten recent articles

Determination of Thiols and Free Thiol Content in a Protein with Liquid Chromatography Coupled to Amperometric Detection at a Silver Based Carbon Paste Electrode

Aydogmus, Z., Sarakbi, A., & Kauffmann, J.-M. (2016). Determination of Thiols and Free Thiol Content in a Protein with Liquid Chromatography Coupled to Amperometric Detection at a Silver Based Carbon Paste Electrode. Electroanalysis, 28(11), 2703-2708. doi:10.1002/elan.201600192  

 

Determination of the anticancer drug sorafenib in serum by adsorptive stripping differential pulse voltammetry using a chitosan/multiwall carbon nanotube modified glassy carbon electrode

Karadas-Bakirhan, N., Patris, S., Ozkan, S., Can, A., & Kauffmann, J.-M. (2016). Determination of the anticancer drug sorafenib in serum by adsorptive stripping differential pulse voltammetry using a chitosan/multiwall carbon nanotube modified glassy carbon electrode. Electroanalysis, 28(2), 10.1002/elan.201500384, 358-365. doi:10.1002/elan.201500384  

 

Antibodies as target for affinity biosensors

Patris, S., Vandeput, M., & Kauffmann, J.-M. (2016). Antibodies as target for affinity biosensors. TrAC. Trends in analytical chemistry, 79, 239-246. doi:10.1016/j.trac.2015.12.005  

 

Flow-through enzyme immobilized amperometric detector for the rapid screening of acetylcholinesterase inhibitors by flow injection analysis.

Vandeput, M., Parsajoo, C., Vanheuverzwijn, J., Patris, S., Yardim, Y., le Jeune, A., Sarakbi, A., Mertens, D., & Kauffmann, J.-M. (2014). Flow-through enzyme immobilized amperometric detector for the rapid screening of acetylcholinesterase inhibitors by flow injection analysis. Journal of pharmaceutical and biomedical analysis, 102C, 267-275. doi:10.1016/j.jpba.2014.09.012  

 

A new chemical criteria for white wine: The glutathione equivalent capacity

Sarakbi, A., & Kauffmann, J.-M. (2014). A new chemical criteria for white wine: The glutathione equivalent capacity. Food chemistry, 153, 321-326. doi:10.1016/j.foodchem.2013.12.090  

 

Highly sensitive determination of iodide by ion chromatography with amperometric detection at a silver-based carbon paste electrode.

Malongo, T. K., Patris, S., Macours, P., Cotton, F., Nsangu, J., & Kauffmann, J.-M. (2008). Highly sensitive determination of iodide by ion chromatography with amperometric detection at a silver-based carbon paste electrode. Talanta, 76(3), 540-547. doi:10.1016/j.talanta.2008.03.053  

 

Electroanalytical behaviour of a nanoarray self-assembled thiocholesterol gold electrode

Yang, Z., Kauffmann, J.-M., Valenzuela, M.-I. A., & Özkan, S. (1999). Electroanalytical behaviour of a nanoarray self-assembled thiocholesterol gold electrode. Mikrochimica acta, 131(1-2), 85-90.  

 

Preparation and Characterization of Octadecylamine-Containing Carbon Paste Electrodes

Amine, A., Deni, J., & Kauffmann, J.-M. (1994). Preparation and Characterization of Octadecylamine-Containing Carbon Paste Electrodes. Analytical chemistry, 66(9), 1595-1599.  

 

Hydrophobic stripping voltammetry using a lipid-modified glassy carbon electrode

Chastel, O., Kauffmann, J.-M., Patriarche, G., & Christian, G. D. (1989). Hydrophobic stripping voltammetry using a lipid-modified glassy carbon electrode. Analytical chemistry, 61(2), 170-173. doi:10.1021/ac00177a018  

 

Preparation and characterization of graphite modified metallic electrodes

Kauffmann, J.-M., Laudet, A., Patriarche, G., & Christian, G. D. (1982). Preparation and characterization of graphite modified metallic electrodes: the graphite modified spray electrode. Talanta, 29(12), 1077-1082. doi:10.1016/0039-9140(82)80221-X