Department of Pharmacotherapy and Pharmaceutics (DPP)

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RESEARCH ACTIVITIES

The research activities cover two areas. 

The first one concerns clinical notions and the exploration of interactions between plants and conventional drugs on the basis of the HEDRINE database. HEDRINE is a tool for advising health professionals about interactions to help them make good choices and for a better management of patient. 

The other part concerns more fondamental aspects of metabolomics of based on plants and in particular the modification of the metabolome between plant products (phytomedecine / food supplements) absorbed per os and the fraction that has passed the digestive barrier. 

Selected publications


Untargeted metabolomics approach to discriminate mistletoe commercial products

Vanhaverbeke, C., Touboul, D., Elie, N., Prévost, M., Meunier, C. C., Michelland, S. S., Cunin, V. V., Ma, L., Vermijlen, D., Delporte, C., Pochet, S., Le Gouellec, A. A., Sève, M. M., Van Antwerpen, P., & Souard, F. (2021). Untargeted metabolomics approach to discriminate mistletoe commercial products. Scientific report.  

 

Antibacterial Activities of Homemade Matrices Miming Essential Oils Compared to Commercial Ones

Oliveira Ribeiro, S., Fontaine, V., Mathieu, V., Abdesselam, Z., Dominique, B., Caroline, S., & Souard, F. (2021). Antibacterial Activities of Homemade Matrices Miming Essential Oils Compared to Commercial Ones. Antibiotics, 10(5), 584. doi:10.3390/antibiotics10050584  

 

Does the Phytochemical Diversity of Wild Plants Like the Erythrophleum genus Correlate with Geographical Origin?

Delporte, C., Noret, N., Vanhaverbeke, C., Hardy, O. J., Martin, J.-F., Tremblay-Franco, M., Touboul, D., Gorel, A. P., Faes, M., Stevigny, C., Van Antwerpen, P., & Souard, F. (2021). Does the Phytochemical Diversity of Wild Plants Like the Erythrophleum genus Correlate with Geographical Origin? Molecules (Print Archive Edition), 26(6), 1668. doi:10.3390/molecules26061668  

 

Antibacterial and Cytotoxic Activities of Ten Commercially Available Essential Oils

Oliveira Ribeiro, S., Fontaine, V., Mathieu, V., Stevigny, C., Souard, F., et al. (2020). Antibacterial and Cytotoxic Activities of Ten Commercially Available Essential Oils. Antibiotics, 9, 0717.  

 

Two in one: bifunctional derivatives of trolox acting as antimalarial and antioxidant agents

Souard, F., Nicolle, E., Cressend, D., Valentin, A., & Boumendjel, A. (2020). Two in one: bifunctional derivatives of trolox acting as antimalarial and antioxidant agents. Future Medicinal Chemistry, 12(20), 1845-1854. doi:10.4155/fmc-2020-0106  

 

Mistletoe-Extract Drugs Stimulate Anti-Cancer Vγ9Vδ2 T Cells.

Ma, L., Phalke, S. P., Stevigny, C., Souard, F., & Vermijlen, D. (2020). Mistletoe-Extract Drugs Stimulate Anti-Cancer Vγ9Vδ2 T Cells. Cells, 9(6). doi:10.3390/cells9061560  

 

A new potential anti?cancer beta?carboline derivative decreases the expression levels of key proteins involved in glioma aggressiveness: A proteomic investigation

De Carvalho, A., Viaene, J., Vandenbussche, G., De Braekeleer, K., Masereel, B., Wouters, J., Souard, F., Vander Heyden, Y., Van Antwerpen, P., Delporte, C., & Mathieu, V. (2020). A new potential anti?cancer beta?carboline derivative decreases the expression levels of key proteins involved in glioma aggressiveness: A proteomic investigation. Drug development research, 8(1), 32-42. doi:10.1002/ddr.21600  

 

Determination of three main chlorogenic acids in water extracts of coffee leaves by liquid chromatography coupled to an electrochemical detector

Rodríguez-Gómez, R., Vanheuverzwjin, J., Souard, F., Delporte, C., Stevigny, C., Stoffelen, P., De Braekeleer, K., & Kauffmann, J.-M. (2018). Determination of three main chlorogenic acids in water extracts of coffee leaves by liquid chromatography coupled to an electrochemical detector. Antioxidants, 7(10), 143. doi:10.3390/antiox7100143  

 

Metabolomics fingerprint of coffee species determined by untargeted-profiling study using LC-HRMS

Souard, F., Delporte, C., Stoffelen, P., Thévenot, E. E., Noret, N., Dauvergne, B., Kauffmann, J.-M., Van Antwerpen, P., & Stevigny, C. (2018). Metabolomics fingerprint of coffee species determined by untargeted-profiling study using LC-HRMS. Food chemistry, 245, 603-612. doi:10.1016/j.foodchem.2017.10.022  

 

Contrasting cadmium resistance strategies in two metallicolous populations of Arabidopsis halleri.

Corso, M., Schvartzman, M. S., Guzzo, F., Souard, F., Malkowski, E., Hanikenne, M., & Verbruggen, N. (2018). Contrasting cadmium resistance strategies in two metallicolous populations of Arabidopsis halleri. New phytologist, 218, 283-297. doi:10.1111/nph.14948