Department of Pharmacotherapy and Pharmaceutics (DPP)

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RESEARCH ACTIVITIES

The research activities cover two areas. 

The first one concerns clinical notions and the exploration of interactions between plants and conventional drugs on the basis of the HEDRINE database. HEDRINE is a tool for advising health professionals about interactions to help them make good choices and for a better management of patient. 

The other part concerns more fondamental aspects of metabolomics of based on plants and in particular the modification of the metabolome between plant products (phytomedecine / food supplements) absorbed per os and the fraction that has passed the digestive barrier. 

Selected publications


HDI Highlighter, The First Intelligent Tool to Screen the Literature on Herb-Drug Interactions

Cnudde, A., Watrin, P., & Souard, F. (2022). HDI Highlighter, The First Intelligent Tool to Screen the Literature on Herb-Drug Interactions. Clinical pharmacokinetics. doi:10.1007/s40262-022-01131-4  

 

Targeted and Untargeted Mass Spectrometry-Based Metabolomics for Chemical Profiling of Three Coffee Species

Montis, A., Souard, F., Delporte, C., Stoffelen, P., Stevigny, C., & Van Antwerpen, P. (2022). Targeted and Untargeted Mass Spectrometry-Based Metabolomics for Chemical Profiling of Three Coffee Species. Molecules (Print Archive Edition), 27(10), 3152. doi:10.3390/molecules27103152  

 

Coffee Leaves: An Upcoming Novel Food?

Montis, A., Souard, F., Delporte, C., Stoffelen, P., Stevigny, C., & Van Antwerpen, P. (2021). Coffee Leaves: An Upcoming Novel Food? Planta medica, 87(12-13), 949-963. doi:10.1055/a-1533-0021  

 

Untargeted metabolomics approach to discriminate mistletoe commercial products

Vanhaverbeke, C., Touboul, D., Elie, N., Prévost, M., Meunier, C. C., Michelland, S. S., Cunin, V. V., Ma, L., Vermijlen, D., Delporte, C., Pochet, S., Le Gouellec, A. A., Sève, M. M., Van Antwerpen, P., & Souard, F. (2021). Untargeted metabolomics approach to discriminate mistletoe commercial products. Scientific report, 11, 10.1038/s41598-021-93255-z, 14205.  

 

Proposals for Antimicrobial Testing Guidelines Applied on Ajowan and Spanish Lavender Essential Oils

Oliveira Ribeiro, S., Fraselle, S., Baudoux, D., Zhiri, A., Stevigny, C., & Souard, F. (2021). Proposals for Antimicrobial Testing Guidelines Applied on Ajowan and Spanish Lavender Essential Oils. Planta medica, 87(10/11), 754-763. doi:10.1055/a-1475-0020  

 

Antibacterial Activities of Homemade Matrices Miming Essential Oils Compared to Commercial Ones

Oliveira Ribeiro, S., Fontaine, V., Mathieu, V., Abdesselam, Z., Dominique, B., Caroline, S., & Souard, F. (2021). Antibacterial Activities of Homemade Matrices Miming Essential Oils Compared to Commercial Ones. Antibiotics, 10(5), 584. doi:10.3390/antibiotics10050584  

 

Does the Phytochemical Diversity of Wild Plants Like the Erythrophleum genus Correlate with Geographical Origin?

Delporte, C., Noret, N., Vanhaverbeke, C., Hardy, O. J., Martin, J.-F., Tremblay-Franco, M., Touboul, D., Gorel, A. P., Faes, M., Stevigny, C., Van Antwerpen, P., & Souard, F. (2021). Does the Phytochemical Diversity of Wild Plants Like the Erythrophleum genus Correlate with Geographical Origin? Molecules (Print Archive Edition), 26(6), 1668. doi:10.3390/molecules26061668  

 

Antibacterial and Cytotoxic Activities of Ten Commercially Available Essential Oils

Oliveira Ribeiro, S., Fontaine, V., Mathieu, V., Stevigny, C., Souard, F., et al. (2020). Antibacterial and Cytotoxic Activities of Ten Commercially Available Essential Oils. Antibiotics, 9, 0717.  

 

Two in one: bifunctional derivatives of trolox acting as antimalarial and antioxidant agents

Souard, F., Nicolle, E., Cressend, D., Valentin, A., & Boumendjel, A. (2020). Two in one: bifunctional derivatives of trolox acting as antimalarial and antioxidant agents. Future Medicinal Chemistry, 12(20), 1845-1854. doi:10.4155/fmc-2020-0106  

 

Mistletoe-Extract Drugs Stimulate Anti-Cancer Vγ9Vδ2 T Cells.

Ma, L., Phalke, S. P., Stevigny, C., Souard, F., & Vermijlen, D. (2020). Mistletoe-Extract Drugs Stimulate Anti-Cancer Vγ9Vδ2 T Cells. Cells, 9(6). doi:10.3390/cells9061560