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David Vermijlen
Department of Pharmacotherapy and Pharmaceutics (DPP)
ContactRESEARCH ACTIVITIES
γδ T cells are unconventional T cells that express a γδ T cell receptor (TCR) on their cell surface instead of an αβ TCR as on conventional αβ T cells. γδ T cells can have several roles, including protection against infections and tumors. The general approach of our current research is to obtain insight into human γδ T cells by applying sophisticated molecular biological techniques on clinical samples. Important in vivo findings are then further investigated in vitro in order to understand molecular mechanisms. A main focus of our research is the role and ontogeny of human γδ T cells in early life. This research is leading to novel targets (molecules, cells) for pharmacotherapy.
Publications of David Vermijlen in PubMed :
David is also member of ULB's Center for Research in Immunology (U-CRI)
Selected publications
γδIL17 under control.
Sánchez Sánchez, G., & Vermijlen, D. (2023). γδIL17 under control. The Journal of experimental medicine, 220(2). doi:10.1084/jem.20221921
Surfing on the waves of the human γδ T cell ontogenic sea.
Sánchez Sánchez, G., Tafesse, Y., Papadopoulou, M., & Vermijlen, D. (2023). Surfing on the waves of the human γδ T cell ontogenic sea. Immunological reviews. doi:10.1111/imr.13184
Identification of distinct functional thymic programming of fetal and pediatric human γδ thymocytes via single-cell analysis.
Sánchez Sánchez, G., Papadopoulou, M., Azouz, A., Tafesse, Y., Mishra, A., Chan, J. K. Y., Fan, Y., Verdebout, I., Porco, S., Libert, F., Ginhoux, F., Vandekerckhove, B., Goriely, S., & Vermijlen, D. (2022). Identification of distinct functional thymic programming of fetal and pediatric human γδ thymocytes via single-cell analysis. Nature communications, 13(1), 5842. doi:10.1038/s41467-022-33488-2
Microbial exposure during early human development primes fetal immune cells
Mishra, A., Lai, G. C., Yao, L. J., Aung, T. T., Shental, N., Rotter-Maskowitz, A., Shepherdson, E., Singh, G. S. N., Pai, R., Shanti, A., Wong, R. M. M., Lee, A., Khyriem, C., Dutertre, C. A., Chakarov, S., Srinivasan, K., Shadan, N. B., Zhang, X.-M., Khalilnezhad, S., Cottier, F., Tan, A. S. M., Low, G., Chen, P., Fan, Y., Hor, P. X., Lee, A. K. M., Choolani, M., Vermijlen, D., Sharma, A., Fuks, G., Straussman, R., Pavelka, N., Malleret, B., McGovern, N., Albani, S., Chan, J. K. Y., & Ginhoux, F. (2021). Microbial exposure during early human development primes fetal immune cells. Cell. doi:10.1016/j.cell.2021.04.039
Innate and adaptive γδ T cells: How, when, and why.
Papadopoulou, M., Sánchez Sánchez, G., & Vermijlen, D. (2020). Innate and adaptive γδ T cells: How, when, and why. Immunological reviews. doi:10.1111/imr.12926
Fetal public Vγ9Vδ2 T cells expand and gain potent cytotoxic functions early after birth.
Papadopoulou, M., Dimova, T., Shey, M., Briel, L., Veldtsman, H., Khomba, N., Africa, H., Steyn, M., Hanekom, W. W., Scriba, T. T., Nemes, E., & Vermijlen, D. (2020). Fetal public Vγ9Vδ2 T cells expand and gain potent cytotoxic functions early after birth. Proceedings of the National Academy of Sciences of the United States of America, 117(31), 18638-18648. doi:10.1073/pnas.1922595117
The human fetal thymus generates invariant effector γδ T cells.
Tieppo, P., Papadopoulou, M., Gatti, D., McGovern, N., Chan, J. K. Y., Gosselin, F., Goetgeluk, G., Weening, K., Ma, L., Dauby, N., Cogan, A., donner, C., Ginhoux, F., Vandekerckhove, B., & Vermijlen, D. (2020). The human fetal thymus generates invariant effector γδ T cells. The Journal of experimental medicine, 217(3). doi:10.1084/jem.20190580
TCR Sequencing Reveals the Distinct Development of Fetal and Adult Human Vγ9Vδ2 T Cells.
Papadopoulou, M., Tieppo, P., McGovern, N., Gosselin, F., Chan, J. K. Y., Goetgeluk, G., Dauby, N., Cogan, A., donner, C., Ginhoux, F., Vandekerckhove, B., & Vermijlen, D. (2019). TCR Sequencing Reveals the Distinct Development of Fetal and Adult Human Vγ9Vδ2 T Cells. The Journal of immunology. doi:10.4049/jimmunol.1900592
Broad cytotoxic targeting of acute myeloid leukemia by polyclonal delta one T cells
Di Lorenzo, B., Simões, A. A., Caiado, F., Tieppo, P., Correia, D. D., Carvalho, T., Da Silva, M. G., Déchanet-Merville, J., Schumacher, T. T., Prinz, I., Norell, H., Ravens, S., Vermijlen, D., & Silva-Santos, B. (2019). Broad cytotoxic targeting of acute myeloid leukemia by polyclonal delta one T cells. Cancer immunology research, 7(4), 552-558. doi:10.1158/2326-6066.CIR-18-0647
The checkpoint for agonist selection precedes conventional selection in human thymus
Verstichel, G., Vermijlen, D., Martens, L., Goetgeluk, G., Brouwer, M., Thiault, N., van Caeneghem, Y., De Munter, S., Weening, K., Bonte, S., Leclercq, G., Taghon, T., Kerre, T., Saeys, Y., Van Dorpe, J., Cheroutre, H., & Vandekerckhove, B. (2017). The checkpoint for agonist selection precedes conventional selection in human thymus. Science immunology, 2, eaah4232. doi:10.1126/sciimmunol.aah4232
Career
- Since 2022: WELBIO Investigator, WEL Research Institute
- Since 2012: associate professor at the Department of Pharmacotherapy and Pharmaceutics, ULB
- 2006-2012: post-doctoral research fellow at the Institute for Medical Immunology, Université Libre de Bruxelles (ULB)
- 2003-2006: post-doctoral research fellow at the laboratory of Prof. Adrian Hayday at the Peter Gorer Department of Immunobiology, King’s College London, UK.
- 2003: Ph.D. thesis: “Tumor cell killing by hepatic natural killer cells”, at the VUB (Vrije Universiteit Brussel (VUB), Free University of Brussels)