Department of Pharmacotherapy and Pharmaceutics (DPP)

Unit of Pharmacology, Pharmacotherapy and Pharmaceutical care

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RESEARCH ACTIVITIES
 

Her research interests are in the field of clinic pharmacy, particularly at the level of the first line of care with community pharmacists.

Her research consists of implementation studies of pharmaceutical care in pharmacies, drug consumption analyses and development of new services in community pharmacy.

Her main research interests are in the areas of drug related problem detection, medication adherence and chronic disease screening in community pharmacy. Another part of her research focused on the field of nutrition, in the regulation of food intake through the study of ghrelin.

Selected publications

Diabetes and Cardiovascular Diseases Risk Assessment in Community Pharmacies: An Implementation Study.

Rondeaux S, Braeckman T, Beckwé M, Biset N, Maesschalck J, Duquet N, De Wulf I, Devroey D, De Vriese C.Int J Environ Res Public Health. 2022 Jul 17;19(14):8699. doi: 10.3390/ijerph19148699.PMID: 35886551

Analysis of the Consumption of Drugs Prescribed for the Treatment of Asthma in Belgian Children.

Biset N, Kestens W, Detemmerman D, Lona M, Karakaya G, Ceuppens A, Pochet S, De Vriese C.Int J Environ Res Public Health. 2022 Jan 4;19(1):548. doi: 10.3390/ijerph19010548.PMID: 35010808

Drug-related problems and risk factors related to unplanned hospital readmission among cancer patients in Belgium.

Koubaity M, Lechon AS, Amighi K, Van Nuffelen M, Moreau M, Meert AP, De Vriese C.Support Care Cancer. 2021 Jul;29(7):3911-3919. doi: 10.1007/s00520-020-05916-w. Epub 2021 Jan 3.PMID: 33389085

Adaptation and validation of PCNE drug-related problem classification v6.2 in French-speaking Belgian community pharmacies.

Koubaity M, Lelubre M, Sansterre G, Amighi K, De Vriese C.Int J Clin Pharm. 2019 Feb;41(1):244-250. doi: 10.1007/s11096-018-0773-y. Epub 2019 Jan 4.PMID: 30610541

Implementation study of an intermediate medication review in Belgian community pharmacies.

Lelubre M, Wuyts J, Maesschalck J, Duquet N, Foubert K, Hutsebaut C, Moullin J, De Wulf I, Boussery K, Foulon V, De Vriese C.Res Social Adm Pharm. 2019 Jun;15(6):710-723. doi: 10.1016/j.sapharm.2018.09.002. Epub 2018 Sep 12.PMID: 30241873

Evaluation of compliance with isotretinoin PPP recommendations and exploration of reasons for non-compliance: Survey among French-speaking health care professionals and patients in Belgium.

Lelubre M, Hamdani J, Senterre C, Amighi K, Peres M, Schneider MP, Bugnon O, De Vriese C.Pharmacoepidemiol Drug Saf. 2018 Jun;27(6):668-673. doi: 10.1002/pds.4441. Epub 2018 May 3.PMID: 29726056

Assessment of medication adherence and responsible use of isotretinoin and contraception through Belgian community pharmacies by using pharmacy refill data.

Biset N, Lelubre M, Senterre C, Amighi K, Bugnon O, Schneider MP, De Vriese C.Patient Prefer Adherence. 2018 Jan 19;12:153-161. doi: 10.2147/PPA.S149355. eCollection 2018.PMID: 29403267

Focus on the short- and long-term effects of ghrelin on energy homeostasis.

De Vriese C, Perret J, Delporte C.Nutrition. 2010 Jun;26(6):579-84. doi: 10.1016/j.nut.2009.09.013. Epub 2010 Jan 15.PMID: 20080032 Review.

Ghrelin: a new peptide regulating growth hormone release and food intake.

De Vriese C, Delporte C.Int J Biochem Cell Biol. 2008;40(8):1420-4. doi: 10.1016/j.biocel.2007.04.020. Epub 2007 May 3.PMID: 17544318 Review.

Influence of ghrelin on food intake and energy homeostasis.

De Vriese C, Delporte C.Curr Opin Clin Nutr Metab Care. 2007 Sep;10(5):615-9. doi: 10.1097/MCO.0b013e32829fb37c.PMID: 17693746 Review.

Ghrelin interacts with human plasma lipoproteins.

De Vriese C, Hacquebard M, Gregoire F, Carpentier Y, Delporte C.Endocrinology. 2007 May;148(5):2355-62. doi: 10.1210/en.2006-1281. Epub 2007 Feb 8.PMID: 17289852

Ghrelin degradation by serum and tissue homogenates: identification of the cleavage sites.

De Vriese C, Gregoire F, Lema-Kisoka R, Waelbroeck M, Robberecht P, Delporte C.Endocrinology. 2004 Nov;145(11):4997-5005. doi: 10.1210/en.2004-0569. Epub 2004 Jul 15.PMID: 15256494

Inhaled cytotoxic chemotherapy: clinical challenges, recent developments, and future prospects

Wauthoz, N., Rosiere, R., & Amighi, K. (2020). Inhaled cytotoxic chemotherapy: clinical challenges, recent developments, and future prospects. Expert opinion on drug delivery. doi:10.1080/17425247.2021.1829590  

 

Development of siRNA-loaded chitosan nanoparticles targeting Galectin-1 for the treatment of gliobmastoma multiforme via intranasal administration

Van Woensel, M., Wauthoz, N., Rosiere, R., Mathieu, V., Kiss, R., Lefranc, F., Steelant, B., Van Gool, S. W., Mathivet, T., Gerhardt, H., Amighi, K., & De Vleeschouwer, S. (2016). Development of siRNA-loaded chitosan nanoparticles targeting Galectin-1 for the treatment of gliobmastoma multiforme via intranasal administration. Journal of controlled release, 227, 71-81. doi:10.1016/j.jconrel.2016.02.032  

 

Development of Controlled-Release Cisplatin Dry Powders for Inhalation against Lung Cancers

Levet, V., Rosiere, R., Merlos, R., Fusaro, L., Berger, G., Amighi, K., & Wauthoz, N. (2016). Development of Controlled-Release Cisplatin Dry Powders for Inhalation against Lung Cancers. International journal of pharmaceutics, 515(1-2), 209-220. doi:10.1016/j.ijpharm.2016.10.019  

 

New Inhalation-Optimized Itraconazole Nanoparticle-Based Dry Powders for the Treatment of Invasive Pulmonary Aspergillosis

Duret, C., Wauthoz, N., Sebti, T., Vanderbist, F., & Amighi, K. (2012). New Inhalation-Optimized Itraconazole Nanoparticle-Based Dry Powders for the Treatment of Invasive Pulmonary Aspergillosis. International journal of nanomedicine, 7, 5475-5489. doi:10.2147/IJN.S34091  

 

Lactose characteristics and the generation of the aerosol

Pilcer, G., Wauthoz, N., & Amighi, K. (2012). Lactose characteristics and the generation of the aerosol. Advanced drug delivery reviews, 64(3), doi:10.1016/j.addr.2011.05.003, 233-256.  

 

Formulation strategy and use of excipients in pulmonary drug delivery.

Pilcer, G., & Amighi, K. (2010). Formulation strategy and use of excipients in pulmonary drug delivery. International journal of pharmaceutics, 392(1-2), 1-19. doi:10.1016/j.ijpharm.2010.03.017  

 

Pharmacoscintigraphic and pharmacokinetic evaluation of tobramycin DPI formulations in cystic fibrosis patients

Pilcer, G., Goole, J., Van Gansbeke, B., Blocklet, D., Knoop, C., Vanderbist, F., & Amighi, K. (2008). Pharmacoscintigraphic and pharmacokinetic evaluation of tobramycin DPI formulations in cystic fibrosis patients. European journal of pharmaceutics and biopharmaceutics, 68(2), 413-421. doi:10.1016/j.ejpb.2007.05.005  

 

Preparation and in vitro evaluation of lipidic carriers and fillers for inhalation

Sebti, T., & Amighi, K. (2006). Preparation and in vitro evaluation of lipidic carriers and fillers for inhalation. European journal of pharmaceutics and biopharmaceutics, 63(1), 51-58. doi:10.1016/j.ejpb.2005.11.003  

 

Preparation and characterization of nanocrystals for solubility and dissolution rate enhancement of nifedipine

Hecq, J., Deleers, M., Fanara, D., Vranckx, H., & Amighi, K. (2005). Preparation and characterization of nanocrystals for solubility and dissolution rate enhancement of nifedipine. International journal of pharmaceutics, 299(1-2), 167-177. doi:10.1016/j.ijpharm.2005.05.014  

 

Surfactant induced drug delivery based on the use of thermosensitive polymers

Eeckman, F., Moës, A., & Amighi, K. (2003). Surfactant induced drug delivery based on the use of thermosensitive polymers. Journal of controlled release, 88(1), 105-116. doi:10.1016/S0168-3659(02)00457-1