Department of Pharmacotherapy and Pharmaceutics (DPP)

Contact
 

RESEARCH ACTIVITIES

γδ T cells are unconventional T cells that express a γδ T cell receptor (TCR) on their cell surface instead of an αβ TCR as on conventional αβ T cells. γδ T cells can have several roles, including protection against infections and tumors. The general approach of our current research is to obtain insight into human γδ T cells by applying sophisticated molecular biological techniques on clinical samples. Important in vivo findings are then further investigated in vitro in order to understand molecular mechanisms. A main focus of our research is the role and ontogeny of human γδ T cells in early life. This research is leading to novel targets (molecules, cells) for pharmacotherapy.

David's site :

HERE

TOP 10 RECENT ARTICLES:

Broad Cytotoxic Targeting of Acute Myeloid Leukemia by Polyclonal Delta One T Cells.
Di Lorenzo B, Simões AE, Caiado F, Tieppo P, Correia DV, Carvalho T, da Silva MG, Déchanet-Merville J, Schumacher TN, Prinz I, Norell H, Ravens S, Vermijlen D, Silva-Santos B. Cancer Immunol Res. 2019 Apr;7(4):552-558. doi: 10.1158/2326-6066.CIR-18-0647.
Epub 2019 Mar 20.
PMID: 30894378

γδ T cell responses: How many ligands will it take till we know?
Vermijlen D, Gatti D, Kouzeli A, Rus T, Eberl M. Semin Cell Dev Biol. 2018 Dec;84:75-86. doi: 10.1016/j.semcdb.2017.10.009. Epub 2018 Feb 5. Review.

PMID: 29402644 Free Article

Human papillomavirus oncoproteins induce a reorganization of epithelial-associated γδ T cells promoting tumor formation.
Van Hede D, Polese B, Humblet C, Wilharm A, Renoux V, Dortu E, de Leval L, Delvenne P, Desmet CJ, Bureau F, Jacobs N, Vermijlen D. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9056-E9065. doi: 10.1073/pnas.1712883114. Epub 2017 Oct 10.
PMID: 29073102

The checkpoint for agonist selection precedes conventional selection in human thymus.
Verstichel G, Vermijlen D, Martens L, Goetgeluk G, Brouwer M, Thiault N, Van Caeneghem Y, De Munter S, Weening K, Bonte S, Leclercq G, Taghon T, Kerre T, Saeys Y, Van Dorpe J, Cheroutre H, Vandekerckhove B. Sci Immunol. 2017 Feb 24;2(8). pii: eaah4232. doi: 10.1126/sciimmunol.aah4232.
PMID: 28783686

Effector Vγ9Vδ2 T cells dominate the human fetal γδ T-cell repertoire.
Dimova T, Brouwer M, Gosselin F, Tassignon J, Leo O, Donner C, Marchant A, Vermijlen D. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):E556-65. doi: 10.1073/pnas.1412058112. Epub 2015 Jan 23.
PMID: 25617367

Ontogeny of Innate T Lymphocytes - Some Innate Lymphocytes are More Innate than Others.

Vermijlen D, Prinz I. Front Immunol. 2014 Oct 10;5:486. doi: 10.3389/fimmu.2014.00486. eCollection 2014. Review. Erratum in: Front Immunol. 2015;6:624.
PMID: 25346734


γδ T cells elicited by CMV reactivation after allo-SCT cross-recognize CMV and leukemia.
Scheper W, van Dorp S, Kersting S, Pietersma F, Lindemans C, Hol S, Heijhuurs S, Sebestyen Z, Gründer C, Marcu-Malina V, Marchant A, Donner C, Plachter B, Vermijlen D, van Baarle D, Kuball J. Leukemia. 2013 Jun;27(6):1328-38. doi: 10.1038/leu.2012.374. Epub 2013 Jan 1.


IL-23R and TCR signaling drives the generation of neonatal Vgamma9Vdelta2 T cells expressing high levels of cytotoxic mediators and producing IFN-gamma and IL-17.
Moens E, Brouwer M, Dimova T, Goldman M, Willems F, Vermijlen D. J Leukoc Biol. 2011 May;89(5):743-52. doi: 10.1189/jlb.0910501. Epub 2011 Feb 17.
PMID: 21330350


Human cytomegalovirus elicits fetal γδ T cell responses in utero.
Vermijlen D, Brouwer M, Donner C, Liesnard C, Tackoen M, Van Rysselberge M, Twité N, Goldman M, Marchant A, Willems F. J Exp Med. 2010 Apr 12;207(4):807-21. doi: 10.1084/jem.20090348. Epub 2010 Apr 5.
PMID: 20368575


Targeting human γδ T cells with zoledronate and interleukin-2 for immunotherapy of hormone-refractory prostate cancer.
Dieli F, Vermijlen D, Fulfaro F, Caccamo N, Meraviglia S, Cicero G, Roberts A, Buccheri S, D'Asaro M, Gebbia N, Salerno A, Eberl M, Hayday AC. Cancer Res. 2007 Aug 1;67(15):7450-7. PMID: 17671215